<i>Brucella suis</i> as a cause of late prosthetic joint infection: A case report and review of the literature

Turvey, Shannon L.; Hui, Catherine; Tyrrell, Gregory J.; Singh, Ameeta E.

doi:10.3138/jammi.2.1.010

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…Given our results for the Cambridge Bay area, the detection of Brucella antibodies in sympatric caribou (Carlsson et al 2019; Fig. 2) and the recent documentation of Brucella suis infection in one resident of Ulukhaktok (Turvey et al 2017), it is possible that rangiferine brucellosis is circulating among the muskoxen of the Ulukhaktok area. We believe it is important to prioritize Brucella surveillance for the muskoxen of this area, including testing of contemporary samples and targeted participatory epidemiology studies.…”

Section: Discussionsupporting

confidence: 57%

“…Rangiferine brucellosis continues to be an important public health concern in the Arctic, a place where many people rely on harvesting of caribou, muskoxen ( Ovibos moschatus ) and other wildlife for subsistence (CINE 2005; Meakin and Kurvits 2009; Tomaselli et al 2018a). A human case of Brucella suis infection was recently documented in Ulukhaktok (Turvey et al 2017), community of northern Canada included in our study area.…”

Section: Introductionmentioning

confidence: 99%

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A Transdisciplinary Approach to Brucella in Muskoxen of the Western Canadian Arctic 1989–2016

et al. 2019

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Brucella serostatus was evaluated in 3189 muskoxen sampled between 1989 and 2016 from various locations of the Canadian Arctic archipelago and mainland, near the communities of Sachs Harbour and Ulukhaktok, Northwest Territories, and Cambridge Bay and Kugluktuk, Nunavut. Brucella antibodies were found only in muskoxen sampled around Cambridge Bay, both on southern Victoria Island and on the adjacent mainland (Kent Peninsula). Consistent with participatory epidemiology data documented from local harvesters describing increased Brucella-like syndromes (swollen joints and lameness) and a decreased proportion of juveniles, the apparent Brucella seroprevalence in the sampled muskoxen of the Cambridge Bay area increased from 0.9% (95% CI 0.3–2.1) in the period of 1989–2001 to 5.6% (95% CI 3.3–8.9) in 2010–2016. The zoonotic bacteria Brucella suis biovar 4 was also cultured from tissues of muskoxen sampled on Victoria Island near Ulukhaktok in 1996 (n = 1) and Cambridge Bay in 1998, 2014, and 2016 (n = 3). Overall, our data demonstrate that B. suis biovar 4 is found in muskoxen that are harvested for food and by guided hunts on Victoria Island and Kent Peninsula, adding an important public health dimension to this study. Robust participatory epidemiology data on muskox health and diseases greatly enhanced the interpretation of our Cambridge Bay data and, combined with the serological and microbiological data, provide compelling evidence that the prevalence of B. suis biovar 4 has increased in this area since the late 1990s. This study enhances the available knowledge on Brucella exposure and infection in muskoxen and provides an example of how scientific knowledge and local knowledge can work together to better understand disease status in wildlife.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

A Transdisciplinary Approach to Brucella in Muskoxen of the Western Canadian Arctic 1989–2016

et al. 2019

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“…PJIs, the current consensus is that dual or triple antibiotic therapy may be superior, particularly if the prosthesis is retained. However, there is no agreement on the duration of treatment [22][23][24][25]. While Brucella PJI without radiological loosening is thought to be completely treated through conservative approach and solely with double or triple therapy, surgeons emphasize that performing two-step revision surgery for removal and replacing prosthesis component is mandatory when prosthesis loosening occurs [23,25].…”

Section: Discussionmentioning

confidence: 99%

“…Other researchers have applied a wide range of protocols that are summarized in Table 3 that consist of doxycycline and rifampin for at least 6 weeks and relapse of infectious only occurred in few cases that required continuing the medical treatment for a longer period. Overall, relapse is uncommon, even with shorter treatment durations, and is typically caused by failure to complete treatment or lack of source control rather than antibiotic resistance [23]. Fluri in 2016 reported a case of TKA infected by Brucella.…”

Section: Discussionmentioning

confidence: 99%

Periprosthetic joint infection due to Brucella infection: A report of a rare presentation and review of the literature

Bagherifard¹,

Ghaderi²,

Motaghi³

et al. 2021

IJCR

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Periprosthetic infection (PJI) is a serious complication of total knee arthroplasty (TKA). PJI due to Brucellosis is a very rare entity. In this report, we described the case of knee joint loosening after TKA in a 63-year-old female who arrived with complaints of a restricted range of motion, stiffness, and pain. The diagnosis was made based on clinical, radiological, and laboratory findings. She was treated with antibiotics and two-stage revision surgery. We also reviewed all similar cases in the English literature from the epidemiologic, diagnostic, and treatment aspects and brought suggestions for evaluations before TKA in endemic areas. Authors emphasize that Brucellosis must be considered among differential diagnoses for patients with PJI, especially in endemic areas. Serologic evaluations and long-term blood and joint aspirated fluid culture must be performed when the patient has a history of recurrent febrile illness, joint swelling, and exposure to animals or the consumption of unpasteurized dairy products. Early suspicion of Brucellosis improves the outcome and prevents medical staff from being infected. A double therapy with doxycycline and rifampin for 6 months and performing two-stage revision surgery is the treatment of choice.

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An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source

et al. 2019

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BackgroundErysipelothrix rhusiopathiae is a zoonotic pathogen that causes erysipeloid and is most frequently associated with exposure to domestic swine. Infection of native and prosthetic joints is a rarely reported manifestation.Case presentationWe describe a case of E. rhusiopathiae prosthetic joint infection in a woman with a history of exposure to wild animals in the Canadian Arctic. Patient management involved a 1-stage surgical revision exchange with an antibiotic impregnated cement spacer and 6 weeks of intravenous penicillin G followed by 6 weeks of oral amoxicillin. Ten previously reported cases of E. rhusiopathiae joint infection are reviewed. Recent increases in mortality due to infection with this organism among host animal populations in the Canadian Arctic have generated concern regarding a potential increase in human infections. However, whole genome sequencing (WGS) of the organism was unable to identify a zoonotic origin for this case.ConclusionsConsideration should be given to E. rhusiopathiae as a cause of joint infections if the appropriate epidemiologic and host risk factors exist. Expanded use of WGS in other potential animal hosts and environmental sources may provide important epidemiologic information in determining the source of human infections.

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Brucella suis as a cause of late prosthetic joint infection: A case report and review of the literature

Cited by 3 publications

References 22 publications

A Transdisciplinary Approach to Brucella in Muskoxen of the Western Canadian Arctic 1989–2016

A Transdisciplinary Approach to Brucella in Muskoxen of the Western Canadian Arctic 1989–2016

Periprosthetic joint infection due to Brucella infection: A report of a rare presentation and review of the literature

An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source

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