<i>BRCA1</i> and <i>VDR</i> gene polymorphisms are associated with prostate cancer risk in Mexican men

Martínez‐Nava, Gabriela Angélica; Gómez, Rocío; Burguete-García, Ana I.; Vázquez-Salas, Ruth Argelia; Ventura‐Bahena, Arianna; Torres‐Sánchez, Luisa

doi:10.1002/mc.23187

Cited by 5 publications

(2 citation statements)

References 37 publications

(79 reference statements)

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“…Thirty-two variants have already been reported as polymorphisms. In fact, previous studies have identified some single-nucleotide polymorphisms associated with prostate cancer risk including c.442-34C>T (rs799923), c.1067A>G (rs1799950), c.4837A>T (rs1799966), c.4357+117G>C (rs3737559) for BRCA1 gene and c.1114A>C (rs144848) for BRCA2 gene [ 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

Next-generation sequencing of BRCA1 and BRCA2 genes in Moroccan prostate cancer patients with positive family history

et al. 2021

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Prostate cancer is the most common male cancer in Morocco. Although sporadic forms account for a large proportion of patients, familial forms of prostate cancer are observed in 20% of cases and about 5% are due to hereditary transmission. Indeed, germline mutations in BRCA1/2 genes have been associated with prostate cancer risk. However, the spectrum of these mutations was not investigated in Moroccan Prostate cancer patients. Thereby, the aim of this study was to characterize and to estimate the prevalence of germline BRCA1/2 mutations and large rearrangements in Moroccan patients with familial prostate cancer. The entire coding regions and intron/exon boundaries of BRCA1 and BRCA2 genes have been analyzed by next generation sequencing (NGS) in a total of 30 familial prostate cancer patients. Three pathogenic mutations were detected in four unrelated patients (13.3%). One BRCA1 mutation (c.1953_1956delGAAA) and two BRCA2 mutations (c.7234_7235insG and BRCA2ΔE12). In addition, sixty-three distinct polymorphisms and unclassified variants have been found. Early identification of germline BRCA1/2 mutations may be relevant for the management of Moroccan prostate cancer patients.

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Section: Discussionmentioning

confidence: 99%

Next-generation sequencing of BRCA1 and BRCA2 genes in Moroccan prostate cancer patients with positive family history

et al. 2021

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“…PCa is explored as polygenic with a broader level of ethnic differences [17]. A positive association of polymorphism rs2238135 (G allele) is displayed in Mexican men with a Gleason score of ≥7 [17]. Almost 90% of circulating vitamin D is because of sun exposure.…”

Section: Vdr (Vitamin D (1 25-dihydroxyvitamin D3) Receptor)mentioning

confidence: 99%

Insights into association between urolithiasis and prostate cancer

Sun¹,

Kour²,

Wang³

et al. 2021

JOMH

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Background and objective: Urolithiasis or renal stones form a major urinary tract infection with formation of calciﬁcations in the bladder and uterus. With the lifestyle diseases burgeoning, the renal stones have become a common cause with an approximate 1 in 1000 people affected all over the world with a risk ratio of 3 : 1 in men and women. On the other hand, prostate or genitourinary cancers are well documented to be associated with urolithiasis. Methods: A gene list was prepared from the published NCBI dataset, comprising all the genes related to urolithiasis primarily with mutations (both pathogenic and likely pathogenic Single nucleotide polymorphisms, SNP's) for every particular gene screened later from the published datasets. To see the interactions among all the potential genetic factors, PPI based tools were used and an interaction map was prepared. For the characterization of mutations, we have used gnomAD for verifying all the SNPs whether they are synonymous or nonsynonymous mutations. Results: We outlined the list of genes and discussed the systems bioinformatics integrated approach associated with it. Conclusion: We found a large number of genes common to them and their association is subtly known for immunomodulatory response.

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Circum-Mediterranean influence in the Y-chromosome lineages associated with prostate cancer in Mexican men: A Converso heritage founder effect?

Álvarez-Topete,

Torres-Sánchez,

Hernández-Tobías

et al. 2024

PLoS ONE

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Prostate cancer is the second most common neoplasia amongst men worldwide. Hereditary susceptibility and ancestral heritage are well-established risk factors that explain the disparity trends across different ethnicities, populations, and regions even within the same country. The Y-chromosome has been considered a prototype biomarker for male health. African, European, Middle Eastern, and Hispanic ancestries exhibit the highest incidences of such neoplasia; Asians have the lowest rates. Nonetheless, the contribution of ancestry patterns has been scarcely explored among Latino males. The Mexican population has an extremely diverse genetic architecture where all the aforementioned ancestral backgrounds converge. Trans-ethnic research could illuminate the aetiology of prostate cancer, involving the migratory patterns, founder effects, and the ethnic contributions to its disparate incidence rates. The contribution of the ancestral heritage to prostate cancer risk were explored through a case-control study (152 cases and 372 controls) study in Mexican Mestizo males. Seventeen microsatellites were used to trace back the ancestral heritage using two Bayesian predictor methods. The lineage R1a seems to contribute to prostate cancer (ORadjusted:8.04, 95%CI:1.41–45.80) development, whereas E1b1a/E1b1b and GHIJ contributed to well-differentiated (Gleason ≤ 7), and late-onset prostate cancer. Meta-analyses reinforced our findings. The mentioned lineages exhibited a connection with the Middle Eastern and North African populations that enriched the patrilineal diversity to the southeast region of the Iberian Peninsula. This ancestral legacy arrived at the New World with the Spanish and Sephardim migrations. Our findings reinforced the contribution of family history and ethnic background to prostate cancer risk, although should be confirmed using a large sample size. Nonetheless, given its complex aetiology, in addition to the genetic component, the lifestyle and xenobiotic exposition could also influence the obtained results.

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BRCA1 and VDR gene polymorphisms are associated with prostate cancer risk in Mexican men

Cited by 5 publications

References 37 publications

Next-generation sequencing of BRCA1 and BRCA2 genes in Moroccan prostate cancer patients with positive family history

Next-generation sequencing of BRCA1 and BRCA2 genes in Moroccan prostate cancer patients with positive family history

Insights into association between urolithiasis and prostate cancer

Circum-Mediterranean influence in the Y-chromosome lineages associated with prostate cancer in Mexican men: A Converso heritage founder effect?

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