BRCA1, BRCA2, and Associated Cancer Risks and Management for Male Patients
Heather H. Cheng,
Jeffrey W. Shevach,
Elena Castro
et al.
Abstract:ImportanceHalf of all carriers of inherited cancer-predisposing variants in BRCA1 and BRCA2 are male, but the implications for their health are underrecognized compared to female individuals. Germline variants in BRCA1 and BRCA2 (also known as pathogenic or likely pathogenic variants, referred to here as BRCA1/2 PVs) are well known to significantly increase the risk of breast and ovarian cancers in female carriers, and knowledge of BRCA1/2 PVs informs established cancer screening and options for risk reduction… Show more
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