<i>Brassica nigra</i>plays a remedy role in hepatic and renal damage

Rajamurugan, R; Arumugam, Suyavaran; Selvaganabathy, N.; Ramamurthy, Chitteti; Reddy, G. P. R.; Sujatha, Venugopal; Thirunavukkarasu, Chinnasamy

doi:10.3109/13880209.2012.685129

Cited by 25 publications

(14 citation statements)

References 31 publications

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“…These results are in accordance with those of various authors who prevented the ALT increase using Brassica extracts and DADS as antioxidant treatments (John 2011 ; Rajamurugan et al. 2012 ; Lee et al. 2014 ).…”

Section: Discussionsupporting

confidence: 92%

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Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil

Morales-López

Centeno-Álvarez

Nieto‐Camacho

et al. 2016

Pharmaceutical Biology

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Context: There have been no reports of the extraction of essential oil (EO) from white cabbage [Brassica oleracea L. var. capitata (L.) Alef. f. alba DC. (Brassicaceae)] (Bocfal) or its chemical composition, antioxidant activity, or hepatoprotective effects.Objective: To extract Bocfal EO, to identify and quantify its chemical components, to assess their antioxidant capacity, and to evaluate the hepatoprotective properties of Bocfal EO.Materials and methods: Bocfal EO was obtained using hydrodistillation (200 mm Hg/58 °C). The chemical composition was analyzed using GC-MS and was quantified using GC-FID. The antioxidant activity of Bocfal EO and its main constituents was evaluated using TBARS in rat brain homogenates. A Bocfal EO hepatoprotective effect (192 mg/kg) on acute carbon tetrachloride (CT)-induced liver damage was determined in rats using biochemical markers and histological analysis. Diallyl disulphide (DADS) (1 mmol/kg) was used as a control for comparison.Results: Bocfal EO contained organic polysulphides (OPSs), such as dimethyl trisulphide (DMTS) 65.43 ± 4.92% and dimethyl disulphide (DMDS) 19.29 ± 2.16% as major constituents. Bocfal EO and DMTS were found to be potent TBARS inhibitors with IC50 values of 0.51 and 3 mg/L, respectively. Bocfal EO demonstrated better hepatoprotective properties than did DADS (p < 0.05), although both slightly affected the hepatic parenchyma per se, as observed using histopathology.Discussion and conclusion: The antioxidant properties of Bocfal EO and DMTS may be the mechanism of hepatoprotective action; the parenchymal disturbances by Bocfal EO or DADS alone may be related to the high doses used.

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Section: Discussionsupporting

confidence: 92%

“…Although polar extracts rich in flavonoids were used in those studies (John 2011 ; Rajamurugan et al. 2012 ), Bocfal EO may have similar cholagogue effects, perhaps through activating canalicular membrane transporters to improve the excretion of bile products.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil

Morales-López

Centeno-Álvarez

Nieto‐Camacho

et al. 2016

Pharmaceutical Biology

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“…Brassica nigra is a fast-growing 1-2 m tall annual herb native to the southern Mediterranean region of Europe, growing over a broad temperature range and therefore classified as a stress tolerant species (Duke, 1983). It is occasionally cultivated for its seeds (Rajamurugan et al 2012) as well as for leaves, extracts of which have allelopathic effects due to its secondary plant products (Turk & Tawaha, 2003). However, as a rapidly-growing plant, B. nigra has become an aggressive weed in temperate Europe where it colonizes old fields (Gomaa et al 2012).…”

Section: Introductionmentioning

confidence: 99%

How specialized volatiles respond to chronic and short‐term physiological and shock heat stress in Brassica nigra

Kask

Kännaste

Talts

et al. 2016

Plant Cell & Environment

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Brassicales released volatile glucosinolate breakdown products upon tissue mechanical damage, but it is unclear how glucosinolate volatile release responds to abiotic stresses such as heat stress. We used three different heat treatments called as mild -and long-term stress and shock-heating to gain insight into stress-dependent changes in volatile blends and photosynthetic characteristics in Brassica nigra (L.) Koch. The reduction in net assimilation rate (A) in temperature response curve measurements was associated with decreases in stomatal conductance, while the moderate reduction due to long-term stress after exposure to 40-44 °C and collapse of photosynthetic activity after heat shock stress were associated with non-stomatal processes. Mild stress decreased constitutive monoterpene emissions parallel to photosynthesis, while long-term heat stress at 40-44 °C and heat shock stress resulted the emissisons of lipoxygenase (LOX) pathway and glucosinolate volatiles. However, glucosinolate volatile emission was more strongly elicited by long-term stress, and glucosinolate volatiles dominated the emissions in long-term stressed plants, while LOX products dominated the emissions after heat shock. These results demonstrate that glucosinolate volatiles constitute a major part of emission blend in heat-stressed B. nigra plants, especially upon chronic stress that leads to induction responses.

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“…The workers studied consumed alcohol only occasionally, at a certain time, and at most once a month. The amounts were also low, namely one glass or one can of alcohol, whereas the toxic effects of alcohol depend on the dose and duration of consumption (Rajamurugan et al, 2012).…”

Section: Discussionmentioning

confidence: 96%

Benzene Exposure Analysis in Informal Shoe Industry Workers in Sukajaya Village, West Java via Leukocyte Count and S-Phenylmercapturic Acid Measurement in Urine

Agustina

Wulandari

2019

PHI

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Background: Benzene is a hematotoxic and carcinogenic compound contained in the glue used in the shoe industry. This compound has been suspected of causing decreased leukocyte counts, which is one of the blood cell production disorders. Benzene exposure can be determined by measuring the concentration of S-phenylmercapturic acid (S-PMA) in urine.Objective: This study was conducted to determine the association between S-PMA urine concentration and the leukocyte count of shoe industry workers.Methods: The study design was cross sectional and the data were collected by conducting interviews, analyzing urine samples for S-PMA concentrations, and conducting blood examinations. Chi square and multiple logistic regression were used for the analysis.Results: The results showed there were no concentrations of S-PMA in urine that exceeded the Biological Exposure Index (BEI) value (≤25 μg/g creatinine). Higher S-PMA concentrations in this study show a higher risk of decreased leukocyte counts. When controlling for age, duration of work, history of infection, Body Mass Index (BMI), smoking, occupation, and exercise, workers with high S-PMA urine concentration were found to be at higher risk of a decreased leukocyte count.Conclusion: Although S-PMA urine concentrations were still below BEI values, workers with higher S-PMA urine concentration were more at risk of leukocyte counts of 5.0 x 103/μL. The decrease in the minimum BEI S-PMA limit value was lower than the current standard may need to be considered.

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Brassica nigraplays a remedy role in hepatic and renal damage

Cited by 25 publications

References 31 publications

Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil

Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil

How specialized volatiles respond to chronic and short‐term physiological and shock heat stress in Brassica nigra

Benzene Exposure Analysis in Informal Shoe Industry Workers in Sukajaya Village, West Java via Leukocyte Count and S-Phenylmercapturic Acid Measurement in Urine

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