Brassica‐derived isothiocyanates as anticancer therapeutic agents and their nanodelivery

Abstract

The isothiocyanates (ITCs) derived from the precursor glucosinolate molecules present in Brassica vegetables are bioactive organo‐sulfur compounds with numerous pharmacologically important properties such as antioxidant, antiinflammatory, antimicrobial, and anticancer. Over the years, ITCs have been the focus of several research investigations associated with cancer treatment. Due to their potent chemo‐preventive action, ITCs have been considered to be promising therapeutics for cancer therapy in place of the already existing conventional anticancer drugs. However, their wide spread use at the clinical stage is greatly restricted due to several factors such as low solubility in an aqueous medium, low bioavailability, low stability, and hormetic effect. To overcome these hindrances, nanotechnology can be exploited to develop nano‐scale delivery systems that have the potential to enhance stability, and bioavailability and minimize the hermetic effect of ITCs.

Advances in Organosulfur-Based Polymers for Drug Delivery Systems

“…This work thoroughly examines the progress made and plausible futuristic research directions in this area. Polymers based on organosulfur moieties have a lot of different qualities that make them useful for medicine delivery packages [1]. Their natural biocompatibility means that there will be no undesired side effects when working with plant systems, which makes them suitable for specific medical uses.…”