BRAFV600E vs. TIRADS in predicting papillary thyroid cancers in Bethesda system I, III, and V nodules

Wu, Yunong; Xu, Ting; Cao, Xingyue; Zhao, Xin; Deng, Hongyan; Wang, Jianxiang; Xiao, Li; Yao, Qing; Ye, Xinhua; Shen, Mingqiang; Wu, Xiaohong

doi:10.20892/j.issn.2095-3941.2018.0291

Cited by 21 publications

(5 citation statements)

References 31 publications

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“…For these reasons, several models have been proposed for the direct integration of molecular and sonographic data [100][101][102]. These models have yet to be validated in multicenter and prospective studies.…”

Section: Molecular Diagnosticsmentioning

confidence: 99%

Thyroid Nodule Characterization: How to Assess the Malignancy Risk. Update of the Literature

et al. 2021

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Ultrasound (US) is the first imaging modality for thyroid parenchyma evaluation. In the last decades, the role of ultrasound has been improved with the introduction of new US software, such as contrast-enhanced ultrasound (CEUS) and US-elastography (USE). USE is nowadays recognized as an essential part of the multiparametric ultrasound (MPUS) examination, in particular for the indeterminate thyroid nodule with possible fine-needle aspiration cytology (FNAC) number reduction; even if further and larger studies are needed to validate it. More controversial is the role of CEUS in thyroid evaluation, due to its high variability in sensitivity and specificity. Semi-automatic US systems based on the computer-aided diagnosis (CAD) system are producing interesting results, especially as an aid to less experienced operators. New knowledge on the molecular mechanisms involved in thyroid cancer is allowing practitioners to identify new genomic thyroid markers that could reduce the number of “diagnostic” thyroidectomies. We have therefore drawn up an updated representation of the current evidence in the literature for thyroid nodule multiparametric ultrasound (MPUS) evaluation with particular regard to USE, the US CAD system and CEUS.

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Section: Molecular Diagnosticsmentioning

confidence: 99%

Thyroid Nodule Characterization: How to Assess the Malignancy Risk. Update of the Literature

et al. 2021

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“…The FNAC has been extensively employed to diagnose thyroid carcinoma and has proven to be reliable in preoperative diagnosis. However, FNAC fails to give definitive diagnosis when the results of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) are indeterminate for categories, such as in the case of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) [4].…”

Section: Introductionmentioning

confidence: 99%

Risk Stratification of Thyroid Nodules with Bethesda III Category: The Experience of a Territorial Healthcare Hospital

Dawish

Robert

Shehri

et al. 2020

Cureus

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Background The Bethesda System for Reporting Thyroid Cytolopathology (TBSRTC) is the standardized category-based reporting system for thyroid nodule (TN) aspirations; however, atypia of undetermined significance/follicular lesion of undetermined significance (Bethesda category III, AUS/FLUS) is the most controversial category. The aim of this study was to identify the degree of malignancy risk and the related risk factors in the surgical pathology of the Bethesda Category III thyroid nodules. The nodules with AUS/FLUS cytology malignancy rate are comparable with the earlier estimations of other countries. The ACR TI-RAD displayed more accurate diagnostic performances in predicting malignancy in the Bethesda III nodules. However, to confirm the accuracy of the molecular marker tests in specific cytological scenarios, more extensive studies are required in the future.

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“…Some studies have shown the rates of malignancy in TBSRTC category I, III, and V nodules were 15.3%, 39.3%, and 96.8%, respectively, and BRAF V600E exhibited similar diagnostic performance to that of TIRADS in BSRTC III/V nodules, the combination of the two diagnostic approaches significantly enhanced the sensitivity, especially among high TBSRTC higher TIADRS score and a TBSRTC score. [ 23 ]…”

Section: Discussionmentioning

confidence: 99%

Fine-needle Aspiration Washout Precipitation Specimens: An Acceptable Supplement to Genetic Mutation Detection of Thyroid Nodules

Cui

Huang

Guo

et al. 2021

Technol Cancer Res Treat

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Objectives: Thyroid nodules are common in adults, but only some of them are malignant. Ultrasound-guided fine-needle aspiration (FNA) is widely applied as a reliable and minimally invasive technique for evaluating thyroid nodules. However, the scarcity of FNA biopsy specimens poses a challenge to molecular diagnosis. This study aimed to evaluate the feasibility of FNA washout precipitation specimens as an effective supplement to the thyroid genetic test. Methods: A total of 115 patients with thyroid nodules were enrolled in our study. The BRAF V600E mutation status was detected in all FNA washout precipitation specimens and biopsy formalin-fixed paraffin-embedded (FFPE) specimens using an amplification refractory mutation system PCR (ARMS-PCR). All patients underwent cytological diagnoses; 79 patients also underwent surgery for histopathological analysis. Results: All the 115 samples were successfully analyzed using both FNA washout precipitation and biopsy FFPE specimens. The results showed that the BRAF V600E status detected in 96 FNA washout precipitation specimens were consistent with that in FNA biopsy FFPE specimens, including 41 BRAF V600E positive and 55 BRAF V600E negative, achieving a concordance rate of 84.4% (kappa = 0.689). Furthermore, the BRAF V600E mutation status using FNA washout precipitation specimens provided a 100.0% positive predictive value for diagnosing papillary thyroid carcinoma in patients with The Bethesda system for reporting thyroid cytopathology (TBSRTC) V. Besides, the BRAF V600E mutation status was positive in 90.9% (10/11) FNA washout precipitation specimens from patients with capsule invasion, achieving a higher overall sensitivity of 100.0%, compared with 57.1% of FNA washout precipitation specimens from patients without capsule invasion. Conclusion: These results suggested that FNA washout precipitation specimens might be a valuable supplementary sample type for detecting the BRAF V600E mutation in patients with thyroid nodules, especially with thyroid capsule invasion.

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BRAF^V600E vs. TIRADS in predicting papillary thyroid cancers in Bethesda system I, III, and V nodules

Cited by 21 publications

References 31 publications

Thyroid Nodule Characterization: How to Assess the Malignancy Risk. Update of the Literature

Thyroid Nodule Characterization: How to Assess the Malignancy Risk. Update of the Literature

Risk Stratification of Thyroid Nodules with Bethesda III Category: The Experience of a Territorial Healthcare Hospital

Fine-needle Aspiration Washout Precipitation Specimens: An Acceptable Supplement to Genetic Mutation Detection of Thyroid Nodules

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