<i>Boswellia serrata</i>resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis

Chou, Ya Chun; Suh, Joon Hyuk; Wang, Yu; Pahwa, Manoj; Badmaev, Vladimir; Ho, Chi Tang; Pan, Min‐Hsiung

doi:10.1002/mnfr.201600984

Cited by 25 publications

(19 citation statements)

References 33 publications

(39 reference statements)

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“…The relative organ weight in each group only the spleen weight of AOM/DSS group was heavier than other groups, due to the DSS cause inflammation in spleen (Perše and Cerar 2012) (Table 1). Table 2 shows that AOM/DSS treatment significantly reduced the colon length, which was also observed in several other studies (Neufert, Becker et al 2007, Chou, Suh et al 2017, Zhang, Su et al 2018. Dietary supplementation with NOB and DMNB restored the colon length (mm) to 78.3 ± 14.3 and 90.6 ± 14.4, and 81.2 ± 10.2 and 101.3 ± 11.4, at 0.01 and 0.025% NOB or DMNB, respectively, compared to 67.4 ± 6.0 in the AOM/DSStreated group.…”

Section: Dmnb Exhibited Higher Activity In Preventing Colonic Tumor Fsupporting

confidence: 84%

5-Demethylnobiletin is more effective than nobiletin in preventing AOM/DSS-induced colorectal carcinogenesis in ICR mice

Wu¹,

Tung²,

Zheng³

et al. 2018

JFB

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Nobiletin and 5-demethylnobiletin as polymethoxyflavone and hydroxy polymethoxyflavone, especially, have been reported to exhibit various beneficial biological activities for human health. In this study, the effects of NOB and 5-demethylnobiletin (DMNB), on azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal carcinogenesis in Institute for Cancer Research (ICR) mice were compared. We found that NOB and DMNB significantly alleviated the weight loss, colon length and reduced colon tumor formation in AOM/DSS-induced colorectal carcinogenesis mice. At the molecular level, our results from western blot and polymerase chain reaction (PCR) analysis showed that 0.025% of NOB and DMNB presented an anti-inflammation property by reducing cyclooxygenase- 2 (COX-2) and interleukin 6 (IL-6) expression. Taken together, these results demonstrate that DMNB had a better chemo-preventive efficacy than NOB in AOM/DSS-induced colorectal carcinogenesis in ICR mice model.

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Section: Dmnb Exhibited Higher Activity In Preventing Colonic Tumor Fsupporting

confidence: 84%

5-Demethylnobiletin is more effective than nobiletin in preventing AOM/DSS-induced colorectal carcinogenesis in ICR mice

Wu¹,

Tung²,

Zheng³

et al. 2018

JFB

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“…The purified DNA was eluted using the innuSPEED Stool DNA kit (Analytik Jena AG, Jena, Germany) according to the manufacturer's protocol. The PCR primer sequences from a previous study were used to amplify the 16S rRNA variable region, and the PCR conditions were referred to in the previous reports . Then, the amplicons were used to construct index‐labeled libraries with the Illumina DNA Library Preparation kit (Illumina, San Diego, USA).…”

Section: Methodsmentioning

confidence: 99%

Adzuki Bean Water Extract Attenuates Obesity by Modulating M2/M1 Macrophage Polarization and Gut Microbiota Composition

Lee

Teng

Hsieh

et al. 2019

Molecular Nutrition Food Res

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Scope Obesity is a chronic condition resulting in excessive fat accumulation in adipose tissues. Adipose tissue is now considered as an immune organ, at the crossroads between metabolism and immunity. Thus, this study investigates the effects of adzuki beans on obesity and gut microbiota in high fat diet‐induced mice. Methods and results In this study, adzuki bean hot water extract (AWE) is determined to have the most significant anti‐adipogenic effect; it is able to inhibit lipid accumulation in 3T3‐L1 adipocytes and reduces body weight and adipose tissue weight in a dose‐dependent manner. AWE treatment also decreases M1‐polarized adipose tissue macrophages (ATMs) while inducing M2‐polarized ATMs. The number and size of fat vacuoles in liver lesions are significantly reduced, indicating that AWE could ameliorate steatosis in high fat diet‐induced mice. The results also demonstrate that AWE‐treated groups inhibit adipogenesis via activating the Wnt/β‐catenin pathway and reduce peroxisome proliferator‐activated receptor gamma and CCAAT/enhancer binding proteins α expression. Moreover, the studies confirm that AWE decreases obesity through modulating gut microbiota. Conclusion The results demonstrate that AWE supplementation ameliorates high fat diet‐induced obesity and gut microbiota composition and suggests that AWE may have the potential to be developed into a functional food to improve metabolic disorders.

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“…Von Boswelliasäuren wird berichtet, dass sie bei Kolonkarzinomzellen in der G2/M-Phase den PI3K/ Akt-Signalweg hemmen [34]. Bei Kolonkarzinomzellen hemmte darüber hinaus ein Boswelliaextrakt die Phosphorylierung von Akt und damit auch die Zellproliferation [36]. Durch Blockade dieses Signalweges unterdrückte AKBA (IC 50 ~17 µM) bei Prostatakarzinomzellen deren Proliferation und führte zur Apoptose [42].…”

Section: Signalwege Der Proliferationunclassified

“…Über eine Hemmung von mTOR-Targets durch Acetyl-Lupeolsäure berichteten 2017 Schmidt et al [21]. Bei Kolonkarzinomzellen verminderte ein BE die Zellproliferation durch eine Hemmung der Phosphorylierung von Akt-1 [36].…”

Section: Signalwege Der Proliferationunclassified

Boswelliaextrakte/Boswelliasäuren bei malignen Tumoren: Eine Übersicht

Ammon¹

2019

DZO

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ZusammenfassungHarze der Bäume verschiedener Boswellia-Spezies – pharmazeutisch Olibanum genannt – werden seit Jahrtausenden als Arzneimittel – auch bei Tumoren – verwendet. Seit den 1990er-Jahren häufen sich die Berichte über Antitumorwirkungen von Extrakten aus dem Harz und einigen Inhaltsstoffen, hier insbesondere von Boswelliasäuren. Präklinische Studien zeigten eine Hemmung der Proliferation, Antiangiogenese und der Ausbreitung von Metastasen sowie Induktion von Apoptose bei einer Vielzahl von Tumorzelllinien wie: Leukämie-, Glioblastom-, Meningiom-, Prostata-, Leber-, Mamma-, Kolon-, Pankreas- und Lungenkarzinomzellen.Die Inhaltsstoffe eines Boswelia-Extraktes (BE) verhalten sich in ihrer Antitumorwirkung synergistisch zueinander und auch gegenüber Chemotherapeutika und Bestrahlung. Der Mechanismus der Antitumorwirkung beeinflusst mehrere Transduktionssignalwege und Einzelfaktoren, die mit Proliferation, Apoptose, Angiogenese und Invasion im Zusammenhang stehen. Ihre Aktivierung erfolgt in vielen Fällen durch Phosphorylierungsreaktionen. Letztere werden durch BE und -inhaltsstoffe gehemmt. Eine wichtige Rolle bei der Apoptosewirkung spielt die Aktivierung von Caspasen.Klinische Studien liegen außer bei Hirntumoren nicht vor. Ein Vorteil von BE ist die geringe Toxizität. Dies sollte Anlass zur Durchführung klinischer Studien sein.

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Boswellia serrataresin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis

Cited by 25 publications

References 33 publications

5-Demethylnobiletin is more effective than nobiletin in preventing AOM/DSS-induced colorectal carcinogenesis in ICR mice

5-Demethylnobiletin is more effective than nobiletin in preventing AOM/DSS-induced colorectal carcinogenesis in ICR mice

Adzuki Bean Water Extract Attenuates Obesity by Modulating M2/M1 Macrophage Polarization and Gut Microbiota Composition

Boswelliaextrakte/Boswelliasäuren bei malignen Tumoren: Eine Übersicht

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