Borreliella burgdorferi
factor H-binding proteins are not required for serum resistance and infection in mammals
Nicholas A. Cramer,
Kalya M. Socarras,
Joshua Earl
et al.
Abstract:The causative agent of Lyme disease (LD),
Borreliella burgdorferi
, binds factor H (FH) and other complement regulatory proteins to its surface.
B. burgdorferi
B31 (type strain) encodes five FH-binding proteins (FHBPs): CspZ, CspA, and the OspE paralogs OspE
BBN38
, OspE
BBL39
, and OspE
BBP38
. This study assessed potential correlations between the production of individual FHBPs, FH-binding … Show more
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