<i>Borrelia miyamotoi</i>Infection Presenting as Human Granulocytic Anaplasmosis

Chowdri, Hanumara Ram; Gugliotta, Joseph L.; Berardi, Victor P.; Goethert, Heidi K.; Molloy, Philip J.; Sterling, Sherri L; Telford, Sam R.

doi:10.7326/0003-4819-159-1-201307020-00005

Cited by 120 publications

(85 citation statements)

References 27 publications

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“…In North America, meningoencephalitis was recently described in an elderly immunocompromised patient and from results of a serosurvey of patients from southern New England and New York, B. miyamotoi infection can cause a viral-like illness (Krause et al 2013). These studies support the contention that B. miyamotoi is yet another of the guild of pathogens, which includes the agents of Lyme disease, anaplasmosis, babesiosis, Powassan virus, and the Ehrlichia muris-like agent, associated with blacklegged ticks in North America (Chowdri et al 2013). The discovery of DNA of B. miyamotoi in ticks during a study of B. burgdorferi diversity signaled the possible occurrence of B. miyamotoi in Canada (Ogden et al 2011).…”

Section: Potential Tick-borne Bacterial Pathogenssupporting

confidence: 72%

The Biological Survey of Canada: A Personal History

Danks¹

2017

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Section: Potential Tick-borne Bacterial Pathogenssupporting

confidence: 72%

The Biological Survey of Canada: A Personal History

Danks¹

2017

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“…Ezért magyarországi előfordulásával is számolni kell. Egyelőre sokkal több országban találtak a kullancsokban B. miyamotoi-t, mint amennyiben humán megbetegedést észleltek (1. és 3. táblázat [34][35][36][37][38][39][40]). Ez érthető, hiszen mind a klinikai, mind a laboratóriumi diagnózis nehézkes.…”

Section: Klinikum éS Epidemiológiaunclassified

Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

Szekeres

Lakos²,

Földvári

2017

Orvosi Hetilap

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A Borrelia miyamotoi-t 1995-ben fedezték fel. Ez egy, emberben visszatérő lázat (relapsing fever, febris recurrens) okozó baktérium, amelyet az Ixodes ricinus fajcsoportba tartozó kullancsok terjesztenek. Ez a kórokozó genetikailag, járványtanilag és az általa okozott kórkép tekintetében is különbözik a szintén kullancsok által terjesztett Borrelia burgdorferi sensu lato (Lyme spirochaeta) baktériumoktól. Eddig világszerte több mint 50 heveny lázas megbetegedésben szenvedő páciensből mutatták már ki, ezenfelül három tumoros betegben meningoencephalitist okozott ez a kórokozó. A különböző élőhelyeken található kullancsok és gazdáik fertőzöttségének mértéke, eloszlása és a fertőzés mechanizmusa nem tisztázott még. A B. miyamotoi elsősorban lázat okoz, ami miatt más, kullancsok által terjesztett fertőzésekkel is összetéveszthető. Az utóbbi évek intenzív vizsgálatai alapján nemcsak egyre több földrajzi régióból mutatják ki ezt a baktériumot kullancsokból, de folyamatosan növekszik a publikált humán esetszám is, ezért növek-vő jelentőségű (emerging) kórokozóként tartják számon. Irodalmi áttekintésünkben összegezzük az eddigi ismereteinket a Borrelia miyamotoi-val kapcsolatban. Orv Hetil. 2017; 158(29): 1124-1130. Kulcsszavak: Borrelia miyamotoi, kullancs, visszatérő láz, kullancs által terjesztett fertőzések Borrelia miyamotoi: a recently identified human pathogenic tick-borne relapsing fever spirocheteBorrelia miyamotoi is a recently described relapsing fever spirochete transmitted by ticks of the Ixodes ricinus complex. This pathogen is different from Borrelia burgdorferi sensu lato (the Lyme borreliosis spirochetes) in its epidemiology, ecology and also genetics. Over 50 patients have been described worldwide with Borrelia miyamotoi disease, and three immunocompromised patients were reported with neurological symptoms. Our knowledge about Borrelia miyamotoi infection in ticks and its distribution in different habitats and also the mechanism of the infection is limited. The most common symptom is fever; thus it can be easily confused with other tick-borne diseases. Due to the intensive research in recent years, Borrelia miyamotoi infection in ticks and hosts has been reported from different regions and also the number of patients is increasing, thus this bacterium is considered as an emerging pathogen. In this literature review we would like to summarize the available knowledge about this spirochete.

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“…This Borrelia species was first isolated from Japanese Ixodes ticks in 1995 whereby it was considered a nonpathogenic endogenous tick bacterium until the first human cases of B. miyamotoi infection were reported in Russia some 16 years later [2]. Subsequently, human infections have been described in the USA and most recently in The Netherlands [3][4][5]28]. Circulation of B. miyamotoi between I. ricinus and wild animals has been confirmed in other European countries such as France, Estonia, Poland and Switzerland [29], which has confirmed that the French genotype is identical to an isolate from a Dutch patient [30].…”

Section: Introductionmentioning

confidence: 99%

“…In Europe, the most prevalent tick-borne disease in humans is Lyme borreliosis (LB), caused by a group of bacteria belonging to the Borrelia burgdorferi sensu Iato group with at least five different species infecting humans in Europe [1]. Recently, B. miyamotoi, belonging to the more distantly related relapsing fever group, has been detected in patients in USA, Japan, Russia and The Netherlands [2][3][4][5], and is transmitted by the tick species involved in LB. Ticks can also be infected with other pathogens that might be transmitted to humans [6] (see Table 1).…”

mentioning

confidence: 99%

Emerging Horizons for Tick-Borne Pathogens: From the ‘One Pathogen–one Disease’ Vision to the Pathobiome Paradigm

et al. 2015

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Ticks, as vectors of several notorious zoonotic pathogens, represent an important and increasing threat for human and animal health in Europe. Recent applications of new technology revealed the complexity of the tick microbiome, which may affect its vectorial capacity. Appreciation of these complex systems is expanding our understanding of tick-borne pathogens, leading us to evolve a more integrated view that embraces the 'pathobiome'; the pathogenic agent integrated within its abiotic and biotic environments. In this review, we will explore how this new vision will revolutionize our understanding of tickborne diseases. We will discuss the implications in terms of future research approaches that will enable us to efficiently prevent and control the threat posed by ticks.

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Borrelia miyamotoiInfection Presenting as Human Granulocytic Anaplasmosis

Cited by 120 publications

References 27 publications

The Biological Survey of Canada: A Personal History

The Biological Survey of Canada: A Personal History

Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

Emerging Horizons for Tick-Borne Pathogens: From the ‘One Pathogen–one Disease’ Vision to the Pathobiome Paradigm

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