<i>Blastocystis</i> subtypes in symptomatic and asymptomatic family members and pets and response to therapy

Nagel, R; Cuttell, Leigh; Stensvold, Christen Rune; Mills, Paul C.; Bielefeldt‐Ohmann, Helle; Traub, Rebecca J.

doi:10.1111/j.1445-5994.2011.02626.x

Cited by 88 publications

(86 citation statements)

References 49 publications

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“…Interestingly ST4, which is considered rare outside of Europe ) but has been detected in Australia (Nagel et al, 2014;Nagel et al, 2012), was not present in our dataset. However, this could be due to the low number of individuals that were positive for Blastocystis -further sampling of individuals from different regions is required to definitively establish the incidence and distribution of ST4 in the US.…”

Section: Etc)mentioning

confidence: 45%

Prevalence and genetic diversity of Blastocystis in family units living in the United States

Scanlan

Knight

Song

et al. 2016

Infection, Genetics and Evolution

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Section: Etc)mentioning

confidence: 45%

Prevalence and genetic diversity of Blastocystis in family units living in the United States

Scanlan

Knight

Song

et al. 2016

Infection, Genetics and Evolution

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“…In many studies, pathogenic potential of subtype 3 has been reported (16,31,(33)(34)(35). Also, some investigations have demonstrated that other subtypes such as subtype 1 were associated with symptoms (20,31,34,36).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the pathogenesis of B. hominis subtypes is not investigated but some differences in virulence between Blastocystis subtypes was shown (9,20,31,32). In many studies, pathogenic potential of subtype 3 has been reported (16,31,(33)(34)(35). Also, some investigations have demonstrated that other subtypes such as subtype 1 were associated with symptoms (20,31,34,36).…”

Section: Discussionmentioning

confidence: 99%

A Study of The Genetic Variability of Blastocystis hominis Isolates in Hamadan, West of Iran

Sardarian

Hajilooi

Maghsood

et al. 2012

Jundishapur J Microbiol

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Blastocystis hominis is a common protozoan parasite in the human and many other animals intestine. the parasite pathogenicity is still controversial. A few studies have been conducted on prevalence of B.hominis subtypes in Iran. The results of present study improve our knowledge on B. hominis subtypes in Iran and therefore we can do more investigations on pathogenicity potential of these subtypes in the future. Background:Blastocystis is a common protozoan parasite in mammals, birds, amphibians, reptiles, fish, arthropods, and annelids. This parasite has some subtypes, which pathogenicity status of them still remained controversial. Some of Blastocystis subtypes are potentially pathogenic to human. Objectives: This study has identified the B. hominis subtypes and their prevalence rates in Hamadan. Patients and Methods: During two months of summer 2011, a total number of 250 human fecal samples referred for parasitology examination to Beasat Hospital and a few clinical laboratories of Hamadan city were collected. The samples were examined by direct method and formalin-ether. 41 samples exhibited positive results for B. hominis thereby were cultured in Locke-egg medium. After the growth and in order to genotype identification, B. hominis isolates were amplified by PCR, using seven pairs of sequencestagged site primers. . Results: In this study, three subtypes of B. hominis consisted of one [SB83], two [SB340] and three [SB227] were identified. The most dominant genotype was SB83 with 56.1% frequency. The prevalence rate of genotype SB227 and SB340 were 22% and 7.3%, respectively. Coexistence of genotypes SB83 and SB227 was detected in 14.6% of positive cases. Conclusions: This is the first study in Hamadan on genotyping of B. hominis, which may trigger other epidemiologic and zoonotic studies on different subtypes and hence control clinical manifestations of infection.

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“…With the exception of ST9 only found in humans, the other 8 STs show low to moderate host specificity also by inhabiting various animal groups [3,23,24]. Many authors include these animal groups as representatives of potential reservoirs of zoonotic transmission [16,25]. One more confirmation for the zoonotic potential of Blastocystis sp., is the high occurrence of this parasite among people handling animals, compared with those without contact with animals [18,20,26].…”

Section: Objectivementioning

confidence: 99%

“…People are colonized mainly by ST1 through ST4, containing over 90% of assessments; but depending on the regions and countries, infection by ST5 through ST9 is also detected [10,20]. Nevertheless, that ST3 is the most common ST in humans worldwide, and its occurrence is a frequent finding in analyses of ST distribution, regardless of the geographic derivation of the population [18,25,49,50].…”

Section: Pathogenicity Of Blastocystis Sp Is a Relationship Possiblementioning

confidence: 99%

Genetic diversity and pathogenicity of Blastocystis

Skotarczak¹

2018

Ann Agric Environ Med.

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Blastocystis is a unicellular, anaerobic protist which lives in the intestinal tract of diverse animals, including humans. It was found that the host specificity and the pathogenic potential of different isolates are correlated with sequence variations in the SSU-rRNA gene. Identification of the organism to the species level is still an unresolved challenge. Genetic diversity revisions have led to the identification of 17 subtypes (STs) within the Blastocystis genus, and 9 (ST1 to ST9) have been reported in humans with varying prevalence. Since the members of the genus revealed a large genetic diversity, several molecular modalities of subtyping methods have been developed. Numerous studies on conveying the pathogenic potential to the molecular subtypes are available, but they could not be compared or analysed with the different molecular techniques employed. The use of different approaches may give false positives during diagnosis and the possibility of missed infections. A review of recent scientific literature indicates that the development of PCR assays is needed for molecular epidemiology and for mixed infections in health and disease cohorts, and also to help identify sources of Blastocystis transmission to humans, as well as to identify potential animal and environmental reservoirs. This review summarizes some of the recent progress and improvements in Blastocystis research on genetic diversity, taxonomy, molecular epidemiology, pathogenicity and subtyping methods.

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Blastocystis subtypes in symptomatic and asymptomatic family members and pets and response to therapy

Abstract: Conventional therapy is ineffective for symptomatic Blastocystis infection. The high prevalence of Blastocystis infection within households suggested transmission between humans and their pets. Subtyping analysis of SSU rDNA alone in Blastocystis does not appear to predict pathogenicity.

Cited by 88 publications

References 49 publications

Prevalence and genetic diversity of Blastocystis in family units living in the United States

Prevalence and genetic diversity of Blastocystis in family units living in the United States

A Study of The Genetic Variability of Blastocystis hominis Isolates in Hamadan, West of Iran

Genetic diversity and pathogenicity of Blastocystis

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