blaNDM-1–positiveKlebsiella pneumoniaefrom Environment, Vietnam

Isozumi, Rie; Yoshimatsu, Kumiko; Yamashiro, Tetsu; Hasebe, Futoshi; Nguyen, Binh Minh; Ngo, Tuan Cuong; Yasuda, Shumpei P.; Koma, Takaaki; Shimizu, Kenta; Arikawa, Jiro

doi:10.3201/eid1808.111816

Cited by 79 publications

(53 citation statements)

References 10 publications

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“…The outbreak of NDM-positive isolates from patients in Illinois emphasizes that hospitalized patients are at risk of infections caused by MDR pathogens (9). The epidemic NDM scenario in this hospital may be a harbinger of a much larger problem, as this difficult-to-treat enzyme disseminates into the community (1,3,4), as has been the case for carbapenemase-producing Enterobacteriaceae isolates producing other class B as well as class A and D enzymes (5). Although the majority of NDM-positive isolates from this surveillance study were from patients hospitalized in India and limited to observations from 2008 to 2010, this resistance mechanism continues to disseminate to other countries, as documented by recent scientific literature and data shown here.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dissemination of NDM Metallo-β-Lactamase Genes among Clinical Isolates of Enterobacteriaceae Collected during the SMART Global Surveillance Study from 2008 to 2012

Biedenbach¹,

Bouchillon²,

Hackel³

et al. 2015

Antimicrob Agents Chemother

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Section: Discussionmentioning

confidence: 99%

“…These isolates have now spread to numerous countries worldwide and have been isolated from both the community and inpatient populations as well as from the environment (1)(2)(3)(4)(5)(6). Twelve NDM enzyme variants have been identified in numerous species of Enterobacteriaceae and common nonfermentative Gram-negative bacilli (7,8).…”

mentioning

confidence: 99%

Dissemination of NDM Metallo-β-Lactamase Genes among Clinical Isolates of Enterobacteriaceae Collected during the SMART Global Surveillance Study from 2008 to 2012

Biedenbach¹,

Bouchillon²,

Hackel³

et al. 2015

Antimicrob Agents Chemother

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“…This clearly showed for the first time that the problem of NDM-1 was not confined to hospital strains of bacteria, but was widespread in the community environment in India, highlighting the need for improvements in sanitary conditions as a key public health intervention. Interestingly, a recent report from Vietnam (described by the authors as a country with strong cultural and economic links with India) also documented environmental contamination with NDM, with two water samples from the Kim Nguu river, which flows through the centre of Hanoi, giving positive PCR results for bla NDM-1 (Isozumi et al, 2012). Both PCR-positive samples, which were obtained from river sites 3 km apart, yielded growth of NDM-positive K. pneumoniae of ST283, indicating a likely high level of contamination of the river with this carbapenem-resistant opportunist pathogen.…”

Section: Epidemiological Link Of Ndm With the Indian Subcontinentmentioning

confidence: 97%

Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance

Johnson¹,

Woodford²

2013

Journal of Medical Microbiology

378

286

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The rapidity with which new types of antibiotic resistance can disseminate globally following their initial emergence or recognition is exemplified by the novel carbapenemase New Delhi metallo-blactamase (NDM). The first documented case of infection caused by bacteria producing NDM occurred in 2008, although retrospective analyses of stored cultures have identified the gene encoding this enzyme (bla NDM ) in Enterobacteriaceae isolated in 2006. Since its first description, NDM carbapenemase has been reported from 40 countries worldwide, encompassing all continents except South America and Antarctica. The spread of NDM has a complex epidemiology involving the spread of a variety of species of NDM-positive bacteria and the interstrain, inter-species and inter-genus transmission of diverse plasmids containing bla NDM , with the latter mechanism having played a more prominent role to date. The spread of NDM illustrates that antibiotic resistance is a public health problem that transcends national borders and will require international cooperation between health authorities if it is to be controlled.

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“…A patient who was hospitalized in Ho Chi Minh City in 2011 was found to have NDM-positive K. pneumoniae when she was hospitalized in the United States shortly after (152). Interestingly, NDM-positive K. pneumoniae was also cultured from the environment (seepage water) in Vietnam in 2011 (153), just like in South Asia.…”

Section: Vietnam There Is No National or Regional Antimicrobial Resimentioning

confidence: 99%

“…CP-CRE have also been isolated from the community and environment in several South and Southeast Asian countries, including India, Pakistan, and Vietnam (14,85,87,153). In the first of these studies done in India, Walsh and coworkers showed that NDM-positive Enterobacteriaceae could be isolated from seepage and even tap water throughout New Delhi (14).…”

Section: Drivers Of Carbapenem-resistant Gram-negative Bacteriamentioning

confidence: 99%

Carbapenem-Resistant Acinetobacter baumannii and Enterobacteriaceae in South and Southeast Asia

et al. 2017

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SUMMARY Carbapenem-resistant Gram-negative bacteria, in particular the Acinetobacter baumannii-calcoaceticus complex and Enterobacteriaceae, are escalating global public health threats. We review the epidemiology and prevalence of these carbapenem-resistant Gram-negative bacteria among countries in South and Southeast Asia, where the rates of resistance are some of the highest in the world. These countries house more than a third of the world's population, and several are also major medical tourism destinations. There are significant data gaps, and the almost universal lack of comprehensive surveillance programs that include molecular epidemiologic testing has made it difficult to understand the origins and extent of the problem in depth. A complex combination of factors such as inappropriate prescription of antibiotics, overstretched health systems, and international travel (including the phenomenon of medical tourism) probably led to the rapid rise and spread of these bacteria in hospitals in South and Southeast Asia. In India, Pakistan, and Vietnam, carbapenem-resistant Enterobacteriaceae have also been found in the environment and community, likely as a consequence of poor environmental hygiene and sanitation. Considerable political will and effort, including from countries outside these regions, are vital in order to reduce the prevalence of such bacteria in South and Southeast Asia and prevent their global spread.

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bla_NDM-1–positiveKlebsiella pneumoniaefrom Environment, Vietnam

Cited by 79 publications

References 10 publications

Dissemination of NDM Metallo-β-Lactamase Genes among Clinical Isolates of Enterobacteriaceae Collected during the SMART Global Surveillance Study from 2008 to 2012

Dissemination of NDM Metallo-β-Lactamase Genes among Clinical Isolates of Enterobacteriaceae Collected during the SMART Global Surveillance Study from 2008 to 2012

Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance

Carbapenem-Resistant Acinetobacter baumannii and Enterobacteriaceae in South and Southeast Asia

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