Bifidobacterium longum subsp. infantis FJSYZ1M3 ameliorates DSS-induced colitis by maintaining the intestinal barrier, regulating inflammatory cytokines, and modifying gut microbiota

Abstract

B. longum subsp. infantis was a subspecies of Bifidobacterium longum, and very few strains were shown to have immunomodulatory effects. In the present study, the improvement of dextran sulphate sodium...

Bifidobacterium longumsubsp. infantis CCFM1269 promotes intestinal barrier and release of IFN-β through TLR4-TRIF dependent way in growing mice

“…lactis HY8002, and B. longum subsp. infantis BB-02) can repair disease-induced damage to the intestinal barrier and upregulate tight junction protein expression [40][41][42] . We found that supplementation of B. longum subsp.…”

Bifidobacterium bifidum Ameliorates DSS-Induced Colitis in Mice by Regulating Microbial Metabolome and Targeting Gut Microbiota

“…Increased levels of myeloperoxidase (MPO), an enzyme predominantly expressed and released by neutrophils, are indicative of the degree of colonic neutrophil infiltration and tissue damage. 11 Notably, dysbiosis of the gut microbiota is a common occurrence in both IBD patients and mice. Hence, rectifying gut microbiota dysbiosis has emerged as a promising therapeutic approach for managing intestinal inflammation.…”

Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022

“…A prior clinical trial found that combining B. longum trisporus with mesalazine improved the therapeutic effect of drugs used for UC ( Jiang et al, 2020 ), inferring that trisporus could be a safe and convenient supplementary treatment option for patients who are resistant to traditional medications. Overall, B. longum may be a useful adjuvant biologic drug in the treatment of UC ( Li et al, 2023 ).…”

“…It is acid- and bile-resistant, is strongly adhesive, does not destroy mucus, is non-invasive, and does not harm the intestinal mucosa ( Ewaschuk et al, 2008 ). B. infantis FJSYZ1M3 can remarkably reduce the DAI, limit weight loss and colonic shortening via alteration of the gut microbiota, maintain the integrity of the intestinal barrier, and modulate levels of inflammatory cytokines ( Li et al, 2023 ). B. infantis also enhances the development of cluster of differentiation (CD) 4+ T cells into Tregs and also increases the expression of IL-10 and TGF-β1, subsequently reducing the inflammatory response in the gut ( Zhou et al, 2022 ).…”