<i>Bifidobacterium longum</i> BL-10 with Antioxidant Capacity Ameliorates Lipopolysaccharide-Induced Acute Liver Injury in Mice by the Nuclear Factor-κB Pathway

Dong, Jiahuan; Ping, Lijun; Meng, Yao; Zhang, Kangyong; Tang, Hongwei; Liu, Deyu; Li, Bailiang; Gui-cheng, Huo

doi:10.1021/acs.jafc.2c02950

Cited by 9 publications

(7 citation statements)

References 56 publications

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“…Oral administration can lower pro-inflammatory cytokines in mice with acute liver injury and mitigate liver damage symptoms through the regulation of the NF-κB signaling pathway. 22 These findings are consistent with our observations. We discovered that Bifidobacterium longum GL001 inhibits the NF-κB signaling pathway while simultaneously activating the Keap1/Nrf2 signaling pathway, exerting anti-inflammatory and antioxidative effects.…”

Section: Discussionsupporting

confidence: 94%

Bifidobacterium longum GL001 alleviates rat intestinal ischemia–reperfusion injury by modulating gut microbiota composition and intestinal tissue metabolism

Tang,

Zhao,

Miao

et al. 2024

Food Funct.

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Section: Discussionsupporting

confidence: 94%

Bifidobacterium longum GL001 alleviates rat intestinal ischemia–reperfusion injury by modulating gut microbiota composition and intestinal tissue metabolism

Tang,

Zhao,

Miao

et al. 2024

Food Funct.

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“…After delivery, the abundance of several potential opportunistic pathogens, including Escherichia_Shigella , Enterococcus , and UBA1819 , increased significantly compared with those during pregnancy. Escherichia_Shigella and UBA1819 are known to be pro-inflammatory bacteria with increased abundances in various inflammatory disease conditions, such as acute liver injury [ 37 ] and colitis [ 38 ]. Enterococcus is known to express metalloproteases, thereby impairing the gut barrier and transmitting into the bloodstream in vulnerable hosts, resulting in inflammatory reactions [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Dynamics of the Gut Microbiota and Faecal and Serum Metabolomes during Pregnancy—A Longitudinal Study

Pan,

Guo,

Chen

et al. 2024

Nutrients

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Normal pregnancy involves numerous physiological changes, including changes in hormone levels, immune responses, and metabolism. Although several studies have shown that the gut microbiota may have an important role in the progression of pregnancy, these findings have been inconsistent, and the relationship between the gut microbiota and metabolites that change dynamically during and after pregnancy remains to be clarified. In this longitudinal study, we comprehensively profiled the temporal dynamics of the gut microbiota, Bifidobacterium communities, and serum and faecal metabolomes of 31 women during their pregnancies and postpartum periods. The microbial composition changed as gestation progressed, with the pregnancy and postpartum periods exhibiting distinct bacterial community characteristics, including significant alterations in the genera of the Lachnospiraceae or Ruminococcaceae families, especially the Lachnospiraceae FCS020 group and Ruminococcaceae UCG-003. Metabolic dynamics, characterised by changes in nutrients important for fetal growth (e.g., docosatrienoic acid), anti-inflammatory metabolites (e.g., trans-3-indoleacrylic acid), and steroid hormones (e.g., progesterone), were observed in both serum and faecal samples during pregnancy. Moreover, a complex correlation was identified between the pregnancy-related microbiota and metabolites, with Ruminococcus1 and Ruminococcaceae UCG-013 making important contributions to changes in faecal and serum metabolites, respectively. Overall, a highly coordinated microbiota–metabolite regulatory network may underlie the pregnancy process. These findings provide a foundation for enhancing our understanding of the molecular processes occurring during the progression of pregnancy, thereby contributing to nutrition and health management during this period.

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“…B . longum BL-10 isolated from healthy baby feces by Dong et al [ 67 ], exhibited better antioxidant performance than B . animalis subsp.…”

Section: Discussionmentioning

confidence: 99%

Identification and evaluation of probiotic potential of Bifidobacterium breve AHC3 isolated from chicken intestines and its effect on necrotizing enterocolitis (NEC) in newborn SD rats

Lin,

2023

PLoS ONE

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Necrotizing enterocolitis (NEC) is a severe intestinal disease of the newborn infants, associated with high morbidity and mortality. It has been reported that Bifidobacterium could protect the intestinal barrier function and reduce the risk of NEC. This study aimed to evaluate the probiotic potential of Bifidobacterium strains isolated from the chicken intestines and its effect on necrotizing enterocolitis in newborn SD rats. Out of 32 isolates, B. breve AHC3 not only exhibited excellent probiotic potential, including tolerance to artificial simulated gastric conditions, adhesion to HT-29 cells, antioxidant capacity and antibacterial activity, but also possessed reliable safety. Additionally, NEC model was established to further investigate the effect of B. breve AHC3 on necrotizing enterocolitis in newborn SD rats. It was illustrated that administration of B. breve AHC3 significantly not only reduced the incidence of NEC (from 81.25% to 34.38%) (P< 0.05), but also alleviated the severity of ileal injury (P< 0.05). Compared with NEC model, B. breve AHC3 could significantly decrease the level of proinflammatory factor TNF-α (P< 0.05) and increase the level of antiinflammatory factor IL-10 (P< 0.05) in the ileum of NEC rats. Through the intervention of B. breve AHC3, the gray value of inducible nitric oxide synthase (iNOS) in intestinal tissue of NEC rats was significantly reduced (P< 0.05). It was indicated that B. breve AHC3 exhibited prominent probiotic potential and reliable safety. In the neonatal SD rat model of NEC, B. breve AHC3 had an available protective effect on the intestinal injury of NEC, which might be related to reducing the inflammatory reaction in the ileum and inhibiting the expression of iNOS in intestinal tissue cells. B. breve AHC3 could be used as a potential treatment for human NEC.

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Bifidobacterium longum BL-10 with Antioxidant Capacity Ameliorates Lipopolysaccharide-Induced Acute Liver Injury in Mice by the Nuclear Factor-κB Pathway

Cited by 9 publications

References 56 publications

Bifidobacterium longum GL001 alleviates rat intestinal ischemia–reperfusion injury by modulating gut microbiota composition and intestinal tissue metabolism

Bifidobacterium longum GL001 alleviates rat intestinal ischemia–reperfusion injury by modulating gut microbiota composition and intestinal tissue metabolism

Dynamics of the Gut Microbiota and Faecal and Serum Metabolomes during Pregnancy—A Longitudinal Study

Identification and evaluation of probiotic potential of Bifidobacterium breve AHC3 isolated from chicken intestines and its effect on necrotizing enterocolitis (NEC) in newborn SD rats

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