<i>Bifidobacterium animalis</i> subsp. <i>lactis</i> A6 attenuates hippocampal damage and memory impairments in an ADHD rat model

Yin, Xindi; Liu, Weichen; Feng, Haihong; Huang, Jiaqiang; Wang, Qi; Zhang, Qi; He, Jingjing; Wang, Ran

doi:10.1039/d3fo04665f

Cited by 2 publications

(1 citation statement)

References 71 publications

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“…A comprehensive study including these brain regions may be required to prove the efficacy of TB for ADHD symptoms. Fourth, although SHR is one of the most common animal models for ADHD, 21–25,73 it is controversial. 74,75 Studies using various animal models, such as DAT-knockout mice and neonatal 6-hydroxydopamine-lesioned rats, 74,75 may increase the significance of TB in relieving ADHD symptoms.…”

Section: Discussionmentioning

confidence: 99%

Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats

Matsuzaki,

Sugimoto,

Hossain

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats

Matsuzaki,

Sugimoto,

Hossain

et al. 2024

Food Funct.

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The gut microbiota–brain axis in neurological disorders

You,

Chen,

Yang

et al. 2024

MedComm

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Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as the microbiota–gut–brain axis (MGBA). The MGBA influences the host's nervous system development, emotional regulation, and cognitive function through neurotransmitters, immune modulation, and metabolic pathways. Factors like diet, lifestyle, genetics, and environment shape the gut microbiota composition together. Most research have explored how gut microbiota regulates host physiology and its potential in preventing and treating neurological disorders. However, the individual heterogeneity of gut microbiota, strains playing a dominant role in neurological diseases, and the interactions of these microbial metabolites with the central/peripheral nervous systems still need exploration. This review summarizes the potential role of gut microbiota in driving neurodevelopmental disorders (autism spectrum disorder and attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's and Parkinson's disease), and mood disorders (anxiety and depression) in recent years and discusses the current clinical and preclinical gut microbe‐based interventions, including dietary intervention, probiotics, prebiotics, and fecal microbiota transplantation. It also puts forward the current insufficient research on gut microbiota in neurological disorders and provides a framework for further research on neurological disorders.

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Bifidobacterium animalis subsp. lactis A6 attenuates hippocampal damage and memory impairments in an ADHD rat model

Abstract: Bifidobacterium animalis subsp. lactis A6 ameliorated hippocampal damage and memory impairments in an ADHD rat model by reshaping the gut microbiota composition, alleviating hippocampal neuron loss and inflammation, and regulating neurotransmitter release.

Cited by 2 publications

References 71 publications

Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats

Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats

The gut microbiota–brain axis in neurological disorders

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