<i>BDNF Val66Met</i> polymorphism and peripheral protein levels in pediatric bipolar disorder and attention‐deficit/hyperactivity disorder

Zeni, Cristian Patrick; Tramontina, Silzá; Aguiar, Bianca Wollenhaupt de; Salatino-Oliveira, Angélica; Pheula, Gabriel Ferreira; Sharma, Alok; Stertz, Laura; Maia, Carlos Renato Moreira; Hutz, Mara Helena; Kapczinski, Flávio; Rohde, Luís Augusto

doi:10.1111/acps.12587

Cited by 15 publications

(5 citation statements)

References 29 publications

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“…28,29 Although international differences in BD are less well studied in youth as compared to adults, there now are PBD data from multiple countries including Australia/New Zealand, Brazil, China, France, India, Italy, South Korea, Spain, the Netherlands, Turkey, and the UK. 30 In addition to the epidemiologic studies reviewed above, international BD data now include phenomenological, 19,31–33 comorbidity, 19,34 longitudinal, 35,36 treatment, 37,38 neuroimaging and biomarker, 39–41 and high-risk studies. 42,43 Numerous commentaries discuss purported international differences in the prevalence of PBD, which may be attributable to including more subtypes, 1 differences in the interview method, 44 training, 23,45 or the type of sample studied (predominantly manic, depressive, treatment-seeking or registry), or a combination of these.…”

Section: | International Findingsmentioning

confidence: 99%

The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research

et al. 2017

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Objectives Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. Methods An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps. Results Substantial, and increasingly international, research has accumulated regarding the phenomenology, differential diagnosis, course, treatment, and neurobiology of PBD. Prior division around the role of irritability and of screening tools in diagnosis has largely abated. Gold-standard pharmacologic trials inform treatment of manic/mixed episodes, whereas fewer data address bipolar depression and maintenance/continuation treatment. Adjunctive psychosocial treatment provides a forum for psychoeducation and targets primarily depressive symptoms. Numerous neurocognitive and neuroimaging studies, and increasing peripheral biomarker studies, largely converge with prior findings from adults with BD. Conclusions As data have accumulated and controversy has dissipated, the field has moved past existential questions about PBD toward defining and pursuing pressing clinical and scientific priorities that remain. The overall body of evidence supports the position that perceptions about marked international (US vs elsewhere) and developmental (pediatric vs adult) differences have been overstated, although additional research on these topics is warranted. Traction toward improved outcomes will be supported by continued emphasis on pathophysiology and novel therapeutics.

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Section: | International Findingsmentioning

confidence: 99%

The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research

et al. 2017

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“…Of all the neurotrophic proteins we evaluated, BDNF appears to have been the one most often considered a candidate for a role in the occurrence of ADHD (Shim et al, 2008; Scassellati et al, 2014; Liu et al, 2015). And yet, the data are conflicting, with some studies reporting higher peripheral concentrations (Yeom et al, 2016), and others failing to find any association (Scassellati et al, 2014; Zeni et al, 2016). Gene studies have also failed to produce a coherent relationship between BDNF-related genes and the risk of ADHD (Cho et al, 2010; Zeni et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…And yet, the data are conflicting, with some studies reporting higher peripheral concentrations (Yeom et al, 2016), and others failing to find any association (Scassellati et al, 2014; Zeni et al, 2016). Gene studies have also failed to produce a coherent relationship between BDNF-related genes and the risk of ADHD (Cho et al, 2010; Zeni et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammation during the First Postnatal Month and the Risk of Attention Deficit Hyperactivity Disorder Characteristics among 10 year-old Children Born Extremely Preterm

Allred

Dammann

Fichorova

et al. 2017

J Neuroimmune Pharmacol

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Although multiple sources link inflammation with attention difficulties, the only human study that evaluated the relationship between systemic inflammation and attention problems assessed attention at age 2 years. Parent and/or teacher completion of the Childhood Symptom Inventory-4 (CSI-4) provided information about characteristics that screen for attention deficit hyperactive disorder (ADHD) among 793 10-year-old children born before the 28th week of gestation who had an IQ ≥ 70. The concentrations of 27 proteins in blood spots obtained during the first postnatal month were measured. 151 children with ADHD behaviors were identified by parent report, while 128 children were identified by teacher report. Top-quartile concentrations of IL-6R, TNF-α, IL-8, VEGF, VEFG-R1, and VEGF-R2 on multiple days were associated with increased risk of ADHD symptoms as assessed by a teacher. Some of this increased risk was modulated by top-quartile concentrations of IL-6R, RANTES, EPO, NT-4, BDNF, bFGF, IGF-1, PIGF, Ang-1, and Ang-2. Systemic inflammation during the first postnatal month among children born extremely preterm appears to increase the risk of teacher-identified ADHD characteristics, and high concentrations of proteins with neurotrophic properties appear capable of modulating this increased risk.

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“…However, it is important to note that this correlation did not maintain statistical significance after adjusting for multiple comparisons [ 126 ]. In contrast, Zeni et al (2016a) found no significant association between the rs6265 polymorphism and BDNF serum levels in children and adolescents with BD comorbid with attention-deficit/hyperactivity disorder (ADHD) [ 127 ]. Moreover, Kenna et al (2014) did not see any difference in val66met polymorphism and plasma BDNF concentrations between women with BD and healthy controls [ 128 ].…”

Section: Polymorphismmentioning

confidence: 99%

Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder

Shkundin,

Halaris

2023

JPM

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Brain-Derived Neurotrophic Factor (BDNF) is crucial for various aspects of neuronal development and function, including synaptic plasticity, neurotransmitter release, and supporting neuronal differentiation, growth, and survival. It is involved in the formation and preservation of dopaminergic, serotonergic, GABAergic, and cholinergic neurons, facilitating efficient stimulus transmission within the synaptic system and contributing to learning, memory, and overall cognition. Furthermore, BDNF demonstrates involvement in neuroinflammation and showcases neuroprotective effects. In contrast, BDNF antisense RNA (BDNF-AS) is linked to the regulation and control of BDNF, facilitating its suppression and contributing to neurotoxicity, apoptosis, and decreased cell viability. This review article aims to comprehensively overview the significance of single nucleotide polymorphisms (SNPs) in BDNF/BDNF-AS genes within psychiatric conditions, with a specific focus on their associations with depression, schizophrenia, and bipolar disorder. The independent influence of each BDNF/BDNF-AS gene variation, as well as the interplay between SNPs and their linkage disequilibrium, environmental factors, including early-life experiences, and interactions with other genes, lead to alterations in brain architecture and function, shaping vulnerability to mental health disorders. The potential translational applications of BDNF/BDNF-AS polymorphism knowledge can revolutionize personalized medicine, predict disease susceptibility, treatment outcomes, and guide the selection of interventions tailored to individual patients.

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BDNF Val66Met polymorphism and peripheral protein levels in pediatric bipolar disorder and attention‐deficit/hyperactivity disorder

Abstract: Although the Val66Met polymorphism at the BDNF gene does not seem to play a significant role in children and adolescents with BD or ADHD, BDNF serum levels deserve further attention in future research on neurobiological aspects of BD and ADHD.

Cited by 15 publications

References 29 publications

The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research

The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research

Systemic Inflammation during the First Postnatal Month and the Risk of Attention Deficit Hyperactivity Disorder Characteristics among 10 year-old Children Born Extremely Preterm

Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder

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