<i>Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria</i> (<scp>BIFAP)</scp>: A data resource for pharmacoepidemiology in Spain

Maciá-Martínez, Miguel-Angel; Gil, Miguel; Huerta, Consuelo; Martín‐Merino, Elisa; Alvarez, Alicia; Bryant, Verónica; Montero, Dolores; Team, Bifap

doi:10.1002/pds.5006

Cited by 50 publications

(46 citation statements)

References 65 publications

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“…The present study was performed using two large prospective population‐based databases from Spain: SIDIAP (the Information System for Research in Primary Care; http://www.sidiap.org), 21 and BIFAP (Base de Datos para la Investigación Farmacoepidemiológica en Atencion Primaria; http://www.bifap.org). 22 Briefly, both contain information recorded in anonymized patients' electronic health records collected prospectively by health professionals in Spain during routine visits in primary care. Data include clinical diagnoses coded with the International Classification of Diseases 9th and 10th revisions (ICD‐9, ICD‐10) and the International Classification of Primary Care (ICPC‐2), and information on drugs prescribed in primary care or dispensed in community pharmacies.…”

Section: Methodsmentioning

confidence: 99%

Use of hydrochlorothiazide and risk of skin cancer in a large nested case‐control study in Spain

León‐Muñoz

Duarte‐Salles

Llorente

et al. 2021

Pharmacoepidemiology and Drug

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Purpose Hydrochlorothiazide (HCTZ) use has been linked to skin cancer in northern European countries. We assessed the association between HCTZ exposure and risk of malignant melanoma (MM) and keratinocyte carcinoma (KC) in a European Mediterranean population. Methods Two parallel nested case‐control studies were conducted in Spain using two electronic primary healthcare databases, each one providing data on both exposure and outcomes: SIDIAP and BIFAP. Cancer cases were matched to 10 controls by age and gender through risk‐set sampling. The ORs and 95% CI for MM and KC associated with previous HCTZ use were estimated using conditional logistic regression. In BIFAP, KC cases were further identified as basal cell carcinoma (BCC) or squamous cell carcinoma (SCC). Results In adjusted analyses, both ever and cumulative high (≥50,000 mg) use of HCTZ were associated with an increased risk of KC. The risk estimates for high use were 1.30 (1.26–1.34) in SIDIAP and 1.20 (1.12–1.30) in BIFAP, with a lower risk for BCC (1.11 [1.02–1.21]) than for SCC (1.71 [1.45–2.02]). A dose–response relationship was observed between cumulative doses of HCTZ and KC risk. Inconsistent results were found for high use of HCTZ and risk of MM: 1.25 (1.09–1.43) in SIDIAP and 0.85 (0.64–1.13) in BIFAP. Conclusions In this European Mediterranean population, a high cumulative use of HCTZ was related to an increased risk of KC with a clear dose–response pattern.

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Section: Methodsmentioning

confidence: 99%

Use of hydrochlorothiazide and risk of skin cancer in a large nested case‐control study in Spain

León‐Muñoz

Duarte‐Salles

Llorente

et al. 2021

Pharmacoepidemiology and Drug

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“…We conducted a retrospective cross-sectional study using information from Electronic Health Records (EHRs) registered in the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP) of the Spanish Agency of Medicines and Medical Devices (AEMPS, Madrid, Spain). The detailed profile of the BIFAP database was previously described [ 16 , 17 ]. BIFAP is a real-world data source with information from EHRs from patients who attended primary care facilities of the Spanish National Health System from seven regions of Spain (Aragón, Asturias, Cantabria, Castilla y León, Madrid, Murcia, and Navarra).…”

Section: Methodsmentioning

confidence: 99%

Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data

Hernández-Rodríguez

Sempere-Verdú

Vicens

et al. 2021

IJERPH

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We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeutic subgroups in all individuals 15 years of age and older with polypharmacy (≥5 drugs during ≥6 months) using the Anatomical Therapeutic Chemical classification system level 4, by sex and age group, for both calendar years. The most prescribed drugs were proton-pump inhibitors (PPIs), statins, antiplatelet agents, benzodiazepine derivatives, and angiotensin-converting enzyme inhibitors. The greatest increases between 2005 and 2015 were observed in PPIs, statins, other antidepressants, and β-blockers, while the prevalence of antiepileptics was almost tripled. We observed increases in psychotropic drugs in women and cardiovascular medications in men. By patient´s age groups, there were notable increases in antipsychotics, antidepressants, and antiepileptics (15–44 years); antidepressants, PPIs, and selective β-blockers (45–64 years); selective β-blockers, biguanides, PPIs, and statins (65–79 years); and in statins, selective β-blockers, and PPIs (80 years and older). Our results revealed important increases in the use of specific therapeutic subgroups, like PPIs, statins, and psychotropic drugs, highlighting opportunities to design and implement strategies to analyze such prescriptions’ appropriateness.

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“…The present study describes the epidemiology of miscarriages in routine clinical practice in Spain using data from BIFAP database, which is multiregional database with a total of 9 Autonomous Regions participating which might be representative of the Spanish population in terms of age and sex [ 20 ]. Our study encompassed a total of 155,419 pregnant women identified between 2002 and 2015 in BIFAP, applying a previous and novel algorithm [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…BIFAP includes information of 6857 primary care physicians and pediatricians, including: demographic factors, consultation visits, referrals, hospital admissions, laboratory test results, diagnostic procedures, diagnoses, and prescriptions. BIFAP’s age and sex distribution are comparable to the Spanish population, covering 8.6% of the total Spanish population at the time this study was performed [ 20 , 21 ]. Clinical encoding of diagnoses and symptoms, are included using two coding systems: International Classification of Primary Care—Second Edition (ICPC-2) and ICD-9.…”

Section: Methodsmentioning

confidence: 99%

A Validation Study on the Frequency and Natural History of Miscarriages Using the Spanish Primary Care Database BIFAP

et al. 2021

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(1) Background: There is a major gap of knowledge towards the natural history of miscarriages in electronic medical records. We aimed to calculate the frequency of miscarriages using data from BIFAP database. (2) Methods: We identified all pregnancy losses and carried out a multistep validation exercise. Potential cases with positive predictive values (PPV) of miscarriage confirmation <85% or those confirming other pregnancy loss were excluded. Kaplan–Meier figures and incidence rates (IRs) of miscarriage with 95% confidence intervals (CIs) expressed by 1000 person-weeks were calculated. Stratifying analysis by age, specific high-risk groups, and drug exposure within the pre-pregnancy period were performed restricted to women with recording last menstrual period (LMP). (3) Results: Women with confirmed miscarriage (N = 18,070), tended to be older, with higher frequency of comorbidities and drug utilization. Restricting to women with LPM recorded, IR of miscarriage was 10.89 (CI 95% 10.68–11.10) per 1000 women-weeks, with a median follow-up of 10 weeks (IQR: 8–12). The IR according to age was: 2.71 (CI 95% 2.59–2.84) in those aged <30 years compared to 9.11 (CI 95% 8.55–9.70) in women aged ≥40 years. Advanced maternal age (Hazard Ratio (HR, 95% confidence interval) CI 95%: 3.34 (3.08–3.62)), use of antihypertensives (1.49 (1.21–1.84), and use of drugs classified as D or X during pregnancy (1.17 (1.07–1.29)) showed to be positive predictors associated with increased risk of miscarriages. (4) Conclusion: BIFAP database can be used to identify women suffering from miscarriages, which will serve to further study risk factors associated with miscarriages with special attention to drug utilization.

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Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria (BIFAP): A data resource for pharmacoepidemiology in Spain

Cited by 50 publications

References 65 publications

Use of hydrochlorothiazide and risk of skin cancer in a large nested case‐control study in Spain

Use of hydrochlorothiazide and risk of skin cancer in a large nested case‐control study in Spain

Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data

A Validation Study on the Frequency and Natural History of Miscarriages Using the Spanish Primary Care Database BIFAP

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