<i>Bartonella</i>DNA in Loggerhead Sea Turtles

Valentine, K. Hope; Harms, Craig A.; Cadenas, María Belén; Birkenheuer, Adam J.; Marr, Henry S.; Braun-McNeill, Joanne; Maggi, Ricardo G.; Breitschwerdt, Edward B.

doi:10.3201/eid1306.061551

Cited by 39 publications

(26 citation statements)

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“…were seemingly restricted to rodents or humans. Ungulates and phocids are now known to be infected, and putative Bartonella DNA has been detected even in sea turtles (Valentine et al 2007). B. schoenbuchensis was first isolated from wild roe deer ( Capreolus capreolus ) in Germany (Dehio et al 2001), as well as from French cattle (Rolain et al 2003) and from deer keds ( Lipoptena cervi ) collected from roe deer and red deer in Germany (Dehio et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Molecular Detection ofBartonella schoenbuchensisfrom Ectoparasites of Deer in Massachusetts

Matsumoto

Berrada

Klinger

et al. 2008

Vector-Borne and Zoonotic Diseases

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Deer keds (Lipoptena cervi) are thought to have been introduced into New England from Europe during the 1800s. We sought to determine whether L. cervi from Massachusetts deer contained evidence of infection by Bartonella schoenbuchensis, which appears to be maintained by L. cervi in Europe. Five of 6 keds were found to contain B. schoenbuchensis DNA, and 2 deer ticks cofeeding on deer with such keds did as well. The detection of Bartonella DNA in deer ticks probably represents contamination by infected deer blood.

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Section: Introductionmentioning

confidence: 99%

Molecular Detection ofBartonella schoenbuchensisfrom Ectoparasites of Deer in Massachusetts

Matsumoto

Berrada

Klinger

et al. 2008

Vector-Borne and Zoonotic Diseases

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“…Remarkably, the infection rate may reach up to around 50% in feral cats or rodents and can be as high as 90% in wild ruminants (reviewed in reference 51). Apart from these groups of thoroughly investigated animals, Bartonella infections have been reported for diverse hosts such as bats (240), aquatic mammals (belugas [270]), and even nonmammal vertebrates (sea turtles [423]). Despite certain geographic differences that coincide with vector ecology, it is obvious that Bartonella infections are among the most prevalent bacterial infections worldwide.…”

Section: Epidemiology and Clinical Aspects Epidemiologymentioning

confidence: 99%

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

2012

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SUMMARY Bartonella spp. are facultative intracellular pathogens that employ a unique stealth infection strategy comprising immune evasion and modulation, intimate interaction with nucleated cells, and intraerythrocytic persistence. Infections with Bartonella are ubiquitous among mammals, and many species can infect humans either as their natural host or incidentally as zoonotic pathogens. Upon inoculation into a naive host, the bartonellae first colonize a primary niche that is widely accepted to involve the manipulation of nucleated host cells, e.g., in the microvasculature. Consistently, in vitro research showed that Bartonella harbors an ample arsenal of virulence factors to modulate the response of such cells, gain entrance, and establish an intracellular niche. Subsequently, the bacteria are seeded into the bloodstream where they invade erythrocytes and give rise to a typically asymptomatic intraerythrocytic bacteremia. While this course of infection is characteristic for natural hosts, zoonotic infections or the infection of immunocompromised patients may alter the path of Bartonella and result in considerable morbidity. In this review we compile current knowledge on the molecular processes underlying both the infection strategy and pathogenesis of Bartonella and discuss their connection to the clinical presentation of human patients, which ranges from minor complaints to life-threatening disease.

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“…An increasing number of Bartonella species have been determined to be pathogenic to humans and domestic animals, including B. henselae and B. quintana (Billeter et al, 2008). Recently Bartonella species have been identified in porpoises (Phocoena phocoena; Maggi et al, 2005) and loggerhead sea turtles (Caretta caretta; Valentine et al, 2007), suggesting that the host range of the organism is much broader than previously suspected and that infection of animals in an aquatic environment is possible. It is unknown whether Bartonella spp.…”

mentioning

confidence: 99%