<i>BAL1</i> and <i>BBAP</i> Are Regulated by a Gamma Interferon-Responsive Bidirectional Promoter and Are Overexpressed in Diffuse Large B-Cell Lymphomas with a Prominent Inflammatory Infiltrate

Juszczyński, Przemysław; Kutok, Jeffery L.; Li, Cheng; Mitra, Joydeep; Aguiar, Ricardo C.T.; Shipp, Margaret A.

doi:10.1128/mcb.02351-05

Cited by 112 publications

(171 citation statements)

References 39 publications

(52 reference statements)

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“…Those of PARP-9 and of some RNA virus encoding nonstructural proteins (from the Severe Acute Respiratory Syndrome Coronavirus SARS-CoV, the hepatitis E virus, and the Semliki Forest virus) are indeed able to bind poly(ADP-ribose) (Karras et al, 2005;Egloff et al, 2006). PARP-9 (also called BAL1, B-aggressive lymphoma 1) was identified according to its differential expression in diffuse large B cell lymphomas (DL-BCL), higher in some chemoresistant tumors with poor prognosis, particularly those associating a brisk host inflammatory response due to tumour infiltration by T lymphocytes and dendritic cells (Aguiar et al, 2000;Juszczynski et al, 2006). PARP-9/BAL1 overexpression stimulates cell migration in vitro, suggesting a role for PARP-9/BAL1 in the promotion of malignant B cell migration and dissemination in high risk DLBCL (Aguiar et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Its coactivating property requires functional PARP activity (Goenka et al, 2007). PARP-9/BAL1 is also likely a transcription coactivator, its overexpression in B lymphocytes, stimulated by interferon gamma (IFN␥), inducing the transcription of IFN␥-controlled genes (Juszczynski et al, 2006). PARP-9/BAL1 was shown to interact with BBAP (B-lymphoma and BAL-associated protein), a ring finger E3 ligase of the DELTEX family, capable of heterodimerization with DTX members and self-ubiquitination (Takeyama et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…DELTEX proteins participate in Notch signaling pathway that controls cell fate determination, notably in myogenesis, neurogenesis, lymphogenesis, and intestinal homeostasis (Artavanis-Tsakonas et al, 1999). BBAP was proposed to regulate the subcellular localization of PARP-9/BAL1, sequestering it within the cytoplasm (Juszczynski et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…This region is syntenically conserved in mouse chromosome region 16B3, with the exception of the PARP-15 gene, which is absent in mouse (and species other than primates, Schreiber et al, 2006). Moreover, PARP-9/BAL1 and BBAP genes are located head-to-head, their mRNAs are antisense through their 5Ј extremities, and both genes are controlled by a IFN␥-responsive bidirectional promoter (Juszczynski et al, 2006). Both genes were found to be overexpressed in DLBCL, with a prominent inflammatory infiltrate (Juszczynski et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, PARP-9/BAL1 and BBAP genes are located head-to-head, their mRNAs are antisense through their 5Ј extremities, and both genes are controlled by a IFN␥-responsive bidirectional promoter (Juszczynski et al, 2006). Both genes were found to be overexpressed in DLBCL, with a prominent inflammatory infiltrate (Juszczynski et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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The macroPARP genes parp‐9 and parp‐14 are developmentally and differentially regulated in mouse tissues

Hakmé

Huber

Dollé

et al. 2007

Developmental Dynamics

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The macroPARPs Parp-9 and Parp-14 are macro domain containing poly(ADP-ribose) polymerases involved in transcriptional regulation in response to immunoregulatory cytokines. Their genes reside in the same locus (16B3), and the Parp-9 gene lies head-to-head and shares its promoter with the gene encoding its partner, Bbap. Here, we provide a detailed analysis of Parp-9, Parp-14, and Bbap expression during mouse development and adulthood. Parp-9 is developmentally regulated, and prominently expressed in the thymus and specific regions of the brain and gut. In adults, highest expression is maintained in the thymus and intestine. Parp-14 is more weakly expressed, mainly in the thymus during development and in adulthood. In addition, we show that Bbap is essentially coexpressed with Parp-9 during development and in adult mouse. However, the different levels of their transcripts detected in the developing brain and gut suggest that Bbap and Parp-9 display both common and independent tissue-specific regulations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The macroPARP genes parp‐9 and parp‐14 are developmentally and differentially regulated in mouse tissues

Hakmé

Huber

Dollé

et al. 2007

Developmental Dynamics

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Poly(ADP‐Ribose) Polymerase Enhances Infiltration of Mononuclear Cells in Primary Sjögren's Syndrome Through Interferon‐Induced Protein With Tetratricopeptide Repeats 1–Mediated Up‐Regulation of CXCL10

Tian

Han

Ling

et al. 2020

Arthritis & Rheumatology

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Objective Mononuclear cell infiltration and type I interferon (IFN) system activation play an important role in primary Sjögren's syndrome (SS). We undertook this study to investigate the mechanism of poly(ADP‐ribose) polymerase family member 9 (PARP‐9) on mononuclear cell infiltration triggered by type I IFN. Methods A proteomic study was conducted in peripheral blood mononuclear cells from patients with primary SS (n = 30) and healthy controls (n = 30) to determine differentially expressed proteins (DEPs) (P < 0.05; fold change >1.20). Labial salivary glands (LSGs) were isolated for hematoxylin and eosin staining and immunohistochemical analysis. CD19+ B cells were purified by magnetic cell sorting for immunofluorescence staining, lentivirus–PARP‐9 transfection, and IFNα treatment experiments. PARP‐9 small interfering RNA (siRNA) and DTX3L siRNA were delivered into female NOD/LtJ female mice to determine their effect. Results The overexpression of PARP‐9 and CXCL10 as well as their colocalization was confirmed in primary SS. PARP‐9 levels in LSGs rose with increased Chisholm scores in patients with primary SS. PARP‐9 and DTX3L were present in the infiltrating mononuclear cells from salivary glands in female NOD/LtJ mouse models. Additionally, Ingenuity Pathway Analysis networks of DEPs demonstrated that PARP‐9, STAT1, and IFN‐induced protein with tetratricopeptide repeats 1 (IFIT‐1) participated in the IFN‐related pathway. Furthermore, PARP‐9 could up‐regulate the expression of IFIT1 and CXCL10 in B cells. Moreover, PARP‐9 and CXCL10 could be induced by IFNα in B cells. Conclusion This study is the first to implicate PARP‐9 as a regulator of infiltration of mononuclear cells in primary SS progression and to reveal that PARP‐9 increases CXCL10 expression through up‐regulating IFIT‐1, which is mediated by the phosphorylation of STAT1. PARP‐9 might therefore be a novel therapeutic target for primary SS.

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Robust immunoglobulin class switch recombination and end joining in Parp9‐deficient mice

et al. 2017

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To mount highly specific and adapted immune responses, B lymphocytes assemble and diversify their antibody repertoire through mechanisms involving the formation of programmed DNA damage. Immunoglobulin class switch recombination (CSR) is triggered by DNA lesions induced by activation-induced cytidine deaminase, which are processed to double-stranded DNA break (DSB) intermediates. These DSBs activate the cellular DNA damage response and enroll numerous DNA repair factors, involving poly(ADP-ribose) polymerases Parp1, Parp2, and Parp3 to promote appropriate DNA repair and efficient long-range recombination. The macroParp Parp9, which is overexpressed in certain lymphomas, has been recently implicated in DSB repair, acting together with Parp1. Here, we examine the contribution of Parp9 to the resolution of physiological DSBs incurred during V(D)J recombination and CSR by generating Parp9 mice. We find that Parp9-deficient mice are viable, fertile, and do not show any overt phenotype. Moreover, we find that Parp9 is dispensable for B-cell development. Finally, we show that CSR and DNA end-joining are robust in the absence of Parp9, indicating that Parp9 is not essential in vivo to achieve physiological DSB repair, or that strong compensatory mechanisms exist.

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BAL1 and BBAP Are Regulated by a Gamma Interferon-Responsive Bidirectional Promoter and Are Overexpressed in Diffuse Large B-Cell Lymphomas with a Prominent Inflammatory Infiltrate

Abstract: BAL1 is a transcription modulator that is overexpressed in chemoresistant, diffuse large B-cell lymphomas (DLBCLs).

Cited by 112 publications

References 39 publications

The macroPARP genes parp‐9 and parp‐14 are developmentally and differentially regulated in mouse tissues

The macroPARP genes parp‐9 and parp‐14 are developmentally and differentially regulated in mouse tissues

Poly(ADP‐Ribose) Polymerase Enhances Infiltration of Mononuclear Cells in Primary Sjögren's Syndrome Through Interferon‐Induced Protein With Tetratricopeptide Repeats 1–Mediated Up‐Regulation of CXCL10

Robust immunoglobulin class switch recombination and end joining in Parp9‐deficient mice

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