Bacteroidesbundle of joy: sepsis from a degenerating/necrotic fibroid

Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology

“…They assist in the breakdown of complex carbohydrates in food and produce essential nutrients and energy for the body. In certain cases, Bacteroides may be one of the pathogens leading to sepsis [ 69 ]. Intestinal perforation or rupture, dysbiosis of the gut microbiota, and compromised immune function can allow gut bacteria like Bacteroides to enter the abdominal cavity or bloodstream, triggering infection and sepsis.…”

Clostridium and Bacteroides bacteremia as initial presentation of uterine carcinosarcoma

“…Interestingly, claudin-3 and claudin-4 receptors, transmembrane proteins that mediate clostridium perfringens enterotoxin (CPE) binding and cytolysis, were found to be overexpressed in carcinosarcoma ( Santin et al, 2007 ). Even less commonly encountered is Bacteroides bacteremia secondary to necrotic fibroids, however this has also been observed ( Arnold et al, 2020 ).…”

“…A similar approach was also employed for a patient with Bacteroides bacteremia whose MRI was consistent with a degenerating submucosal fibroid with hemorrhage or necrosis. The patient completed a complete course of antibiotics then proceeded to undergo surgical management with an open myomectomy ( Arnold et al, 2020 ).…”

“…Our case was rare in that this patient had polymicrobial sepsis from both Clostridium and Bacteroides. Although more conservative treatment has been reported, including antibiotics only ( Lichtenberg and Henning, 2004 ) or antibiotics followed by a myomectomy ( Arnold et al, 2020 ), often times it is not adequate for management. In addition, we caution that imaging alone may be insufficient to rule out underlying malignancy.…”