Baccharis trimera (Less.) DC leaf derivatives and eupatorin activities against Leishmania amazonensis

Sahid, Esther Della Nina; Claudino, Josiane Clarice; Oda, Fernando Bombarda; Carvalho, Flávio Alexandre; Santos, André Gonzaga dos; Graminha, Márcia Aparecida Silva; Clementino, Leandro da Costa

doi:10.1080/14786419.2021.1887175

Cited by 5 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2020 L. D. C. CLEMENTINO et. al [43], the compounds from Baccharis trimera aerial parts were extracted and tested for their effectiveness against Leishmania amazonensis and macrophage cells. Its anti-inflammatory, antioxidant, and hepatoprotective properties have been proven by pharmacological research [68] [69].…”

Section: Stems Of Cuscuta Hyalinamentioning

confidence: 99%

Exploration of Antileishmanial Compounds Derived from Natural Sources

Peer¹,

Chang²,

Raj³

et al. 2022

Preprint

View full text Add to dashboard Cite

Leishmaniasis is considered one of the different neglected tropical diseases by the World Health Organization. Over the past few decades to tackle leishmaniasis, effective and novel drugs have progressed. But few are expensive some other medication shows poor effects and few drugs with long treatment lead to cause resistance. But it is very important to start a better medication against leishmania so researchers came to the front of the utilization of natural products which are considered a better option. Finding active compounds in medicinal plants is another alternative to currently accessible medications. Materials and methods: This study examined and reported the far more potential natural products used to treat disease caused by Leishmania spp. Leishmaniasis, plant metabolites, in vivo, in vitro, and treatment against leishmaniasis have been used as search terms in the Google Scholar, PubMed, and Science Direct databases, and only papers published between 2015 and 2021 have been chosen for further analysis. Results: The use of novel natural compounds with leishmanicidal action as well as the leishmanicidal activity of natural compounds against promastigote, axenic, and intracellular amastigote forms were included in roughly 20 research papers that were reviewed.Conclusion: Due to their capacity to selectively target parasites without harming host cell viability, herbal plants are a possible source of new anti-leishmanial medication. Future leishmaniasis treatments will draw on the isolated compounds as a source, completing those already offered in clinics.

show abstract

Section: Stems Of Cuscuta Hyalinamentioning

confidence: 99%

Exploration of Antileishmanial Compounds Derived from Natural Sources

Peer¹,

Chang²,

Raj³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Exploration of Antileishmanial Compounds Derived from Natural Sources

Ghouse Peer,

Priyadarshini,

Gupta

et al. 2024

AIAAMC

View full text Add to dashboard Cite

Leishmaniasis is a deadly tropical disease that is neglected in many countries. World Health Organization, along with a few other countries, has been working together to protect against these parasites. Many novel drugs from the past few years have been discovered and subjected against leishmaniasis, which have been effective but they are quite expensive for lower-class people. Some drugs showed no effect on the patients, and the longer use of these medicines has made resistance against these deadly parasites. Researchers have been working for better medication by using natural products from medicinal plants (oils, secondary metabo-lites, plant extracts) and other alternatives to find active compounds as an alternative to the current synthetic drugs. Materials and Methods: To find more potential natural products to treat Leishmania spp, a study has been conducted and reported many plant metabolites and other natural alternatives from plants and their extracts. Selected research papers with few term words such as natural products, plant metabolites, Leishmaniasis, in vivo, in vitro, and treatment against leishmania-sis; in the Google Scholar, PubMed, and Science Direct databases with selected research papers published between 2015 and 2021 have been chosen for further analysis has been included in this report which has examined either in vivo or in vitro analysis. Results: This paper reported more than 20 novel natural compounds in 20 research papers that have been identified which report a leishmanicidal activity and shows an action against pro-mastigote, axenic, and intracellular amastigote forms. Conclusion: Medicinal plants, along with a few plant parts and extracts, have been reported as a possible novel anti-leishmanial medication. These medicinal plants are considered nontoxic to Host cells. Leishmaniasis treatments will draw on the isolated compounds as a source further and these compounds compete with those already offered in clinics.

show abstract

Bioactivity of Natural Polyphenols as Antiparasitic Agents and their Biochemical Targets

Soto‐Sanchez

2022

MRMC

View full text Add to dashboard Cite

Background: Leishmaniasis and trypanosomiasis are diseases that affect public health worldwide due to their high incidence, morbidity, and mortality. Available treatments are costly, prolonged, and toxic, not to mention the problem of parasite resistance. The development of alternative treatments is justified and polyphenols show promising activity. Objective: The main aim of this mini-review was to analyze the most promising phenolic compounds with reported antileishmanial and antitrypanosomal activity as well as their mechanisms of action. Results: We found that the mode of action of these natural compounds mainly lignans, neolignans, and flavonoids depends on the organism they act on and includes, macrophage activation, induction of morphological changes such as chromatin Conclusion: Although the specific molecular targets, bioavailability, route of administration, and dosages of some of these natural compounds need to be determined, polyphenols and their combinations represent a very promising and safe strategy to be considered for use against Leishmania spp and Trypanosoma spp. In addition, these compounds may provide a scaffold for developing new, more potent, and more selective antiprotozoal agents.

show abstract

Baccharis trimera (Less.) DC leaf derivatives and eupatorin activities against Leishmania amazonensis

Cited by 5 publications

References 24 publications

Exploration of Antileishmanial Compounds Derived from Natural Sources <strong> </strong>

Exploration of Antileishmanial Compounds Derived from Natural Sources <strong> </strong>

Exploration of Antileishmanial Compounds Derived from Natural Sources

Bioactivity of Natural Polyphenols as Antiparasitic Agents and their Biochemical Targets

Contact Info

Product

Resources

About