<i>Autophagy - the friendly fire in endothelial cell regeneration</i>. Focus on “Autophagy in endothelial progenitor cells is cytoprotective in hypoxic conditions”

Sharma, Arun; Wu, Sean M.

doi:10.1152/ajpcell.00046.2013

Cited by 7 publications

(2 citation statements)

References 11 publications

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“…Li and co-workers showed that the promotion of autophagy via LncRNA WTAPP1 against miRNA 3 and 120 accelerated EPC maturation by modulating Akt/PI3K axis and type 1 metalloproteinase. These data highlight the critical role of autophagy on angiogenesis in either in mature or progenitor cell types [ 173 , 174 ]. The beneficial effects of autophagy could direct the angiogenic potential of EPCs under diabetic condition by affecting migration and differentiation rate [ 175 – 177 ].…”

Section: The Correlation Between Autophagy and Angiogenesismentioning

confidence: 94%

Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells

et al. 2018

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Autophagy plays a critical role in the dynamic growth of each cell through different conditions. It seems that this intracellular mechanism acts as a two-edged sword against the numerous cell insults. Previously, autophagy was described in the context of cell activity and behavior, but little knowledge exists related to the role of autophagy in endothelial cells, progenitors, and stem cells biology from different tissues. Angiogenic behavior of endothelial lineage and various stem cells are touted as an inevitable feature in the restoration of different damaged tissues and organs. This capacity was found to be dictated by autophagy signaling pathway. This review article highlights the fundamental role of cell autophagic response in endothelial cells function, stem cells dynamic, and differentiation rate. It seems that elucidation of the mechanisms related to pro- and/or anti-angiogenic potential of autophagy inside endothelial cells and stem cells could help us to modulate stem cell therapeutic feature post-transplantation.

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Section: The Correlation Between Autophagy and Angiogenesismentioning

confidence: 94%

Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells

et al. 2018

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“…For instance, nuclear translocation of TFEB is induced by silver nanoparticles, leading to the expression of autophagy genes and cell survival [ 159 ]. Experiments showed that the protective effects of autophagy cause the proliferation and differentiation of endothelial progenitor cells into endothelial cells [ 160 ]. In another study, a type of sprayable adhesive hydrogel was fabricated and coloaded with a complex of zinc and metformin (ZnMet).…”

Section: Biomaterials and The Role Of Autophagymentioning

confidence: 99%

Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications

Pirmoradi,

Shojaei,

Ghavami

et al. 2023

Pharmaceutics

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Macroautophagy (hereafter autophagy), a tightly regulated physiological process that obliterates dysfunctional and damaged organelles and proteins, has a crucial role when biomaterials are applied for various purposes, including diagnosis, treatment, tissue engineering, and targeted drug delivery. The unparalleled physiochemical properties of nanomaterials make them a key component of medical strategies in different areas, such as osteogenesis, angiogenesis, neurodegenerative disease treatment, and cancer therapy. The application of implants and their modulatory effects on autophagy have been known in recent years. However, more studies are necessary to clarify the interactions and all the involved mechanisms. The advantages and disadvantages of nanomaterial-mediated autophagy need serious attention in both the biological and bioengineering fields. In this mini-review, the role of autophagy after biomaterial exploitation and the possible related mechanisms are explored.

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Significance and therapeutic implications of endothelial progenitor cells in angiogenic-mediated tumour metastasis

Flamini

Jiang

Lane

et al. 2016

Critical Reviews in Oncology/Hematology

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Cancer conveys profound social and economic consequences throughout the world. Metastasis is responsible for approximately 90% of cancer-associated mortality and, when it occurs, cancer becomes almost incurable. During metastatic dissemination, cancer cells pass through a series of complex steps including the establishment of tumour-associated angiogenesis. The human endothelial progenitor cells (hEPCs) are a cell population derived from the bone marrow which are required for endothelial tubulogenesis and neovascularization. They also express abundant inflammatory cytokines and paracrine angiogenic factors. Clinically hEPCs are highly correlated with relapse, disease progression, metastasis and treatment response in malignancies such as breast cancer, ovarian cancer and non-small-cell lung carcinoma. It has become evident that the hEPCs are involved in the angiogenesis-required progression and metastasis of tumours. However, it is not clear in what way the signalling pathways, controlling the normal cellular function of human BM-derived EPCs, are hijacked by aggressive tumour cells to facilitate tumour metastasis. In addition, the actual roles of hEPCs in tumour angiogenesis-mediated metastasis are not well characterised. In this paper we reviewed the clinical relevance of the hEPCs with cancer diagnosis, progression and prognosis. We further summarised the effects of tumour microenvironment on the hEPCs and underlying mechanisms. We also hypothesized the roles of altered hEPCs in tumour angiogenesis and metastasis. We hope this review may enhance our understanding of the interaction between hEPCs and tumour cells thus aiding the development of cellular-targeted anti-tumour therapies.

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Autophagy - the friendly fire in endothelial cell regeneration. Focus on “Autophagy in endothelial progenitor cells is cytoprotective in hypoxic conditions”

Cited by 7 publications

References 11 publications

Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells

Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells

Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications

Significance and therapeutic implications of endothelial progenitor cells in angiogenic-mediated tumour metastasis

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