<i>Aster koraiensis</i> Extract and Chlorogenic Acid Inhibit Retinal Angiogenesis in a Mouse Model of Oxygen‐Induced Retinopathy

Kim, Jung-Hyun; Lee, Yun Mi; Jung, Wookwon; Park, Subin; Kim, Chan-Sik; Kim, Jin Sook

doi:10.1155/2018/6402650

Cited by 15 publications

(16 citation statements)

References 39 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an attempt to evaluate the effects of CGA on retinal neovascularization in a mouse model of oxygen-induced retinopathy, Kim et al [ 126 ] found that CGA inhibited VEGF-mediated tube formation in human vascular endothelial cells and that the neovascular area was significantly smaller in CGA-treated mice than in the vehicle-treated mice, demonstrating the CGA’s anti-angiogenic property.…”

Section: Anti-cancer Effects Of Coffeementioning

confidence: 99%

“…Figure 2 and Figure 3 show possible modulations by CGA, although individual pathways in which CGA is involved have not necessarily been reported. Figure 2 illustrates CGA’s downregulation of ROS [ 2 , 11 , 48 , 120 , 127 ], DNA damage [ 123 ], EGFR [ 127 ], Akt/phosphatidyl 3-inositol kinase (PI3K) [ 127 ], ERK1/2 [ 11 , 127 ], NF-κB [ 2 , 121 , 125 , 127 , 128 ], TNF-α [ 2 , 122 ], IL-1β [ 122 ], IL-8 [ 2 , 11 ], IL-6 [ 122 ], MMPs [ 2 , 11 ], COX-2 [ 125 , 128 ], Bcl-2 [ 10 , 129 ], mTOR [ 10 , 127 ], VEGF [ 126 ], and upregulation of AMPK [ 7 , 49 ]. Although CGA’s upregulation of CaMKK and LKB1 shown in Figure 3 has not been determined yet, Park et al [ 130 ] reported upregulation of them by neochlorogenic acid, an isomer of CGA.…”

Section: Anti-cancer Effects Of Coffeementioning

confidence: 99%

See 1 more Smart Citation

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

et al. 2020

View full text Add to dashboard Cite

Tea and coffee are consumed worldwide and epidemiological and clinical studies have shown their health beneficial effects, including anti-cancer effects. Epigallocatechin gallate (EGCG) and chlorogenic acid (CGA) are the major components of green tea polyphenols and coffee polyphenols, respectively, and believed to be responsible for most of these effects. Although a large number of cell-based and animal experiments have provided convincing evidence to support the anti-cancer effects of green tea, coffee, EGCG, and CGA, human studies are still controversial and some studies have suggested even an increased risk for certain types of cancers such as esophageal and gynecological cancers with green tea consumption and bladder and lung cancers with coffee consumption. The reason for these inconsistent results may have been arisen from various confounding factors. Cell-based and animal studies have proposed several mechanisms whereby EGCG and CGA exert their anti-cancer effects. These components appear to share the common mechanisms, among which one related to reactive oxygen species is perhaps the most attractive. Meanwhile, EGCG and CGA have also different target molecules which might explain the site-specific differences of anti-cancer effects found in human studies. Further studies will be necessary to clarify what is the mechanism to cause such differences between green tea and coffee.

show abstract

Section: Anti-cancer Effects Of Coffeementioning

confidence: 99%

Section: Anti-cancer Effects Of Coffeementioning

confidence: 99%

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A. koraiensis has been reported to inhibit diabetic inflammation [ 29 , 30 ] and enhance wound healing on the skin and during bronchitis [ 31 ]. Moreover, chlorogenic acid and 3,5-di-O-caffeoylquinic acid, both isolated from A. koraiensis , have been used to relieve symptoms of diabetic-related diseases [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Anti-Inflammation Potential of Aster koraiensis Extract for Dry Eye Syndrome by the Protection of Ocular Surface

Hong

Lee

et al. 2020

Nutrients

View full text Add to dashboard Cite

Dry eye syndrome (DES) is a corneal disease often characterized by an irritating, itching feeling in the eyes and light sensitivity. Inflammation and endoplasmic reticulum (ER) stress may play a crucial role in the pathogenesis of DES, although the underlying mechanism remains elusive. Aster koraiensis has been used traditionally as an edible herb in Korea. It has been reported to have wound-healing and inhibitory effects against insulin resistance and inflammation. Here, we examined the inhibitory effects of inflammation and ER stress by A. koraiensis extract (AKE) in animal model and human retinal pigmented epithelial (ARPE-19) cells. Oral administration of AKE mitigated DE symptoms, including reduced corneal epithelial thickness, increased the gap between lacrimal gland tissues in experimental animals and decreased tear production. It also inhibited inflammatory responses in the corneal epithelium and lacrimal gland. Consequently, the activation of NF-κB was attenuated by the suppression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Moreover, AKE treatment ameliorated TNF-α-inducible ocular inflammation and thapsigargin (Tg)-inducible ER stress in animal model and human retinal pigmented epithelial (ARPE-19) cells. These results prove that AKE prevents detrimental functional and histological remodeling on the ocular surface and in the lacrimal gland through inhibition of inflammation and ER stress, suggesting its potential as functional food material for improvement of DES.

show abstract

“…In Korea, A. koraiensis has been occasionally consumed as a seasonal leafy vegetable, and has also traditionally been used as a folk medicine to control stroke, inflammation, and respiratory diseases such as pneumonia, pertussis, and chronic bronchitis (Ahn, 1998;Choi et al, 2017). It has been demonstrated that the extracts and compounds from A. koraiensis have various biological activities, including antioxidant, antidiabetic, antiangiogenic, antithrombotic, chemopreventive, and hepatoprotective activities (Choi et al, 2017;Jung et al, 2002;Kim et al, 2011;Kim et al, 2016;Kim et al, 2018;Lee et al, 2010;Lee et al, 2012;Sohn et al, 2010). Together with these pharmacological activities, its extracts exhibit preventive and therapeutic efficacy against glaucoma, hepatocarcinoma, diabetic retinopathy, and diabetic nephropathy both in vitro and in vivo (Kim et al, 2011;Kim et al, 2016;Kim et al, 2017;Kim et al, 2018;Lee et al, 2010;Sohn et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Open-field Study Investigating Commercial Smart Farming of a Potential Alternative Crop, <i>Aster koraiensis</i>

et al. 2020

View full text Add to dashboard Cite

Aster koraiensis, a plant indigenous to Korea, has recently attracted a great deal of attention as a potential functional food and pharmaceutical product due to its preventive and therapeutic efficacy against various diseases. Despite increasing demand, supply of A. koraiensis is limited to wild populations and small-scale wild plant growers. In an attempt to establish cultivation practices in open-field production platforms, this study investigated the effects of soil mulching, planting density, and fertilizer treatment on the above-ground dry matter yield of A. koraiensis for two years after transplantation. The maximum dry matter yield was obtained at 1,935 kg DW•ha −1 and 3,803 kg DW•ha −1 in the first and second years, respectively, under soil mulching and 15 × 15 cm planting density conditions. Soil mulching during the first year after transplanting significantly promoted plant growth, and increased yield, indicating its beneficial effects on the establishment and early growth of A. koraiensis plants. Fertilizer treatment increased yields up to 3.7-fold in the second year after transplantation. In addition, this study employed remote sensing technologies using a drone equipped with a multispectral sensor to evaluate the normalized difference vegetation index (NDVI) of experimental plots across different plant growth stages. The results revealed that NDVI values at 60 days after shoot emergence in the second year after transplantation produced the highest correlation with dry matter yield in a simple exponential regression model. Remote sensing technologies and the proposed regression model could be applied to optimize cultivation practices and enable precision agriculture for A. koraiensis crops.

show abstract

Aster koraiensis Extract and Chlorogenic Acid Inhibit Retinal Angiogenesis in a Mouse Model of Oxygen‐Induced Retinopathy

Cited by 15 publications

References 39 publications

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

In Vivo Anti-Inflammation Potential of Aster koraiensis Extract for Dry Eye Syndrome by the Protection of Ocular Surface

A Preliminary Open-field Study Investigating Commercial Smart Farming of a Potential Alternative Crop, <i>Aster koraiensis</i>

Contact Info

Product

Resources

About