<i>APOE</i>
            ε4 is not a susceptibility gene in idiopathic or diabetic sensory neuropathy

Zhou, Zhifeng; Höke, Ahmet; Cornblath, David R.; Griffin, John W.; Polydefkis, Michael

doi:10.1212/01.wnl.0000148587.97690.4e

Cited by 10 publications

(14 citation statements)

References 10 publications

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“…Apolipoprotein E polymorphisms have been studied in a number of trials [107][108][109][110]. Results regarding the role of the ε4 allele as a risk factor have been conflicting, but some studies may be criticized because of insufficient patient homogeneity, inconsistent DSPN definition, and small sample size [111].…”

Section: Genetic Factorsmentioning

confidence: 99%

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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■ AbstractDistal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological manifestation in diabetes. Major risk factors of DSPN include diabetes duration, hyperglycemia, and age, followed by prediabetes, hypertension, dyslipidemia, and obesity. Height, smoking, insulin resistance, hypoinsulinemia, and others represent an additional risk. Importantly, hyperglycemia, hypertension, dyslipidemia, obesity, and smoking are modifiable. Stringent glycemic control has been shown to be effective in type 1, but not to the same extent in type 2 diabetes. Antilipidemic treatment, especially with fenofibrate, and multi-factorial intervention have produced encouraging results, but more experience is necessary. The major comorbidities of DSPN are depression, autonomic neuropathy, peripheral artery disease, cardiovascular disease, nephropathy, retinopathy, and medial arterial calcification. Knowledge of risk factors and comorbidities has the potential to enrich the therapeutic strategy in clinical practice as part of the overall medical care for patients with neuropathy. This article provides an updated overview of DSPN risk factors and comorbidities.

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Section: Genetic Factorsmentioning

confidence: 99%

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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“…Two thirds of the HIV-infected subjects in our study had at least one copy of the E4 isoform, which is higher than other studies of HIV-infected subjects 5 or patients with idiopathic or diabetic sensory neuropathy. 21 There are several potential explanations: most of the subjects had neuropathy and this may have resulted in a selection bias. Alternatively, African Americans comprised the majority of our HIVϩ subjects and may have higher rates of ApoE ε4 allele frequency.…”

Section: Figure (A) Post-capsaicin Regression Lines For All Subjectsmentioning

confidence: 99%

Impaired reinnervation in HIV infection following experimental denervation

Hahn¹,

Triolo²,

Hauer³

et al. 2007

Neurology

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“…The evidence on the association between APOE gene polymorphism and diabetic neuropathy is still rather limited and definitive conclusions cannot be drawn [24, 28, 30, 32]. This uncertainty is further enhanced by the important methodological differences between the studies.…”

Section: Discussionmentioning

confidence: 99%

“…The first work included 56 patients with clinically overt neuropathy [30]. These underwent an oral glucose tolerance test and were divided into three groups: patients with normal oral glucose tolerance test, those with impaired glucose tolerance and those with DM.…”

Section: Introductionmentioning

confidence: 99%

“…The ɛ4 allele rate among subjects with DM or impaired glucose tolerance was not significantly different from that of the general population in the United States and Europe, as based on previous prevalence studies. The authors concluded that the ɛ4 allele was not a risk factor for neuropathy [30]. The limitations of the study include the small patient series, the unidentified cause of neuropathy among subjects with normal oral glucose tolerance test and the use of NIS, which may be criticised as not very sensitive for small fibre dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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State of the art paper APOE gene polymorphisms and diabetic peripheral neuropathy

Monastiriotis¹,

Παπάνας²,

Veletza³

et al. 2012

aoms

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Genetic factors may influence the natural course of diabetic peripheral neuropathy and explain some of its variability. The aim of this review was to examine the association between apolipoprotein E (apoE) gene polymorphisms and diabetic peripheral neuropathy. Four relevant studies were identified. The two earlier works provided evidence that the ɛ4 allele is a risk factor for this complication, while the two more recent studies were negative. Important differences in the methodology used and in the populations included are obvious, rendering difficult the comparison between studies. In conclusion, the association between APOE gene polymorphisms and diabetic peripheral neuropathy is still unclear. Available evidence is rather limited and results have so far been contradictory. Future studies should employ more robust methodology, adjusting for potential confounders and for the prevalence of neuropathy in the general population with diabetes.

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APOE ε4 is not a susceptibility gene in idiopathic or diabetic sensory neuropathy

Cited by 10 publications

References 10 publications

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

Impaired reinnervation in HIV infection following experimental denervation

State of the art paper APOE gene polymorphisms and diabetic peripheral neuropathy

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