<i>ANGPTL1</i> Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling

Yan, Qian; Jiang, Lingxi; Liu, Ming; Yu, Dandan; Zhang, Yu; Li, Yan; Fang, Shuo; Zhu, Ying–Hui; Yuan, Yufeng; Guan, Xin‐Yuan

doi:10.1158/0008-5472.can-17-0579

Cited by 67 publications

(81 citation statements)

References 40 publications

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“…Then mesenchymal-like cells invade into vessels where some of them become anoikis resistant and translocate to distant organ to form metastases. Particularly, the metastasis of HCC shares considerable similarities with other cancer types, whereas EMT program and enhanced angiogenesis have been addressed as critical events driving HCC metastasis [145,146].…”

Section: Activating Invasion and Metastasismentioning

confidence: 99%

The role of long noncoding RNAs in hepatocellular carcinoma

et al. 2020

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Hepatocellular carcinoma (HCC) is the most frequent subtype of primary liver cancer and one of the leading causes of cancer-related death worldwide. However, the molecular mechanisms underlying HCC pathogenesis have not been fully understood. Emerging evidences have recently suggested the crucial role of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of HCC. Various HCC-related lncRNAs have been shown to possess aberrant expression and participate in cancerous phenotypes (e.g. persistent proliferation, evading apoptosis, accelerated vessel formation and gain of invasive capability) through their binding with DNA, RNA or proteins, or encoding small peptides. Thus, a deeper understanding of lncRNA dysregulation would provide new insights into HCC pathogenesis and novel tools for the early diagnosis and treatment of HCC. In this review, we summarize the dysregulation of lncRNAs expression in HCC and their tumor suppressive or oncogenic roles during HCC tumorigenesis. Moreover, we discuss the diagnostic and therapeutic potentials of lncRNAs in HCC.

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Section: Activating Invasion and Metastasismentioning

confidence: 99%

The role of long noncoding RNAs in hepatocellular carcinoma

et al. 2020

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“…DADS can inhibit the CCL2 (CC chemokine-2) releasing induced by TNF-α to play an antiangiogenesis role in MDA-MB-231 cells. The decreasing level of CCL2 attenuates the phosphorylation of ERK which is a key molecule of the MAPK signaling pathway, leading to the weakening of angiogenesis in tumor cells [111]. Activation of ERK and Akt signaling can promote the angiogenesis of HCC (hepatocellular carcinoma) [112].…”

Section: The Inhibition Of Angiogenesis By Dadsmentioning

confidence: 99%

The Progress of Diallyl Disulfide in Anti-Cancer

Lz¹,

Liao²,

Wang³

et al. 2017

Chemotherapy

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Considerable evidence in recent years suggests that garlic has anti-proliferative effects on various types of cancer. Garlic contains water-soluble and oil-soluble sulfur compounds. Oil-soluble compounds (OSCs), such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS) and ajoene are more effective than watersoluble compounds in protection against cancer. DADS, a major organosulfur compound derived from garlic, can reduce carcinogen-induced cancers in experimental animals and inhibit the proliferation of various types of cancer cells. The mechanisms of these action of DADS include activation of metabolic enzymes that detoxify carcinogens, suppression of the formation of DNA adducts, antioxidant effects, regulation of cell-cycle progression, induction of apoptosis, and inhibition of angiogenesis and metastasis. These topics are discussed in depth in this review.

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“…STAT3 and HIF‐1α, two major transcription factors that regulate VEGF, have been found to be consistently upregulated in various cancers and associated with poor clinical outcomes in patients . STAT3 is a well‐characterized oncogene that affects various biological processes including promoting cell proliferation and survival by regulating Cyclin D1 and Bcl‐2, inducing tumor invasion and metastasis by regulating E‐cadherin, MMP‐9, promoting angiogenesis by targeting VEGF and HIF1α expression . Angiogenesis is also reported to be linked with STAT3 .…”

Section: Discussionmentioning

confidence: 99%

Downregulation of Rab17 promotes cell proliferation and invasion in non‐small cell lung cancer through STAT3/HIF‐1α/VEGF signaling

Wang

Ding

et al. 2019

Thoracic Cancer

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Background: Rab GTPases play a key role in regulating intercellular vesicle trafficking in both exo-and endocytic pathways. Recent studies have reported that Rab small GTPases and the associated regulatory proteins and effectors are involved in many cancers. The purpose of this study was to investigate the biological role of Rab17 in non-small cell lung cancer (NSCLC) and the relative mechanism. Methods: Rab17 expression in human NSCLC cell lines and tissues was evaluated using real-time PCR (RT-PCR), western blot and immunohistochemical (IHC) staining. NSCLC cell lines with RAB17 stable knockdown were generated to explore its function in vitro and in vivo. Additionally, we investigated the potential mechanism of Rab17 by identifying the expression levels of STAT3/ HIF-1α/VEGF pathway using western blot analysis. Results: Decreased Rab17 expression was correlated with poor overall survival in NSCLC patients. The functional assays showed that knockdown of Rab17 could promote tumorigenic properties of NSCLC cells in vitro and in vivo, including enhanced cell proliferation, colony formation, invasion and migration, angiogenesis and tumor xenograft growth, and suppressed apoptosis. Moreover, Rab17 downregulation decreased epithelial marker E-cadherin and increased mesenchymal markers Vimentin and β-catenin, suggesting knockdown of Rab17 induced epithelial-mesenchymal transition (EMT). Conclusion: Downregulation of Rab17 promotes cell invasion and enhances tumorigenicity in part through the STAT3/HIF-1α/VEGF pathway, which may represent a novel potential therapeutic target.

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ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling

Cited by 67 publications

References 40 publications

The role of long noncoding RNAs in hepatocellular carcinoma

The role of long noncoding RNAs in hepatocellular carcinoma

The Progress of Diallyl Disulfide in Anti-Cancer

Downregulation of Rab17 promotes cell proliferation and invasion in non‐small cell lung cancer through STAT3/HIF‐1α/VEGF signaling

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