<i>An Empirical Formula for Indicator-Dilution Curves as Obtained in Human Beings</i>

Stow, Richard W.; Hetzel, Peter S.

doi:10.1152/jappl.1954.7.2.161

Cited by 56 publications

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“…From the empirical point of view it was noted that the relation was approximated by a normal distribution if a log scale was used on the horizontal rather than the vertical axis. Stow and Hetzel 20 reported a reasonable fit. Although such curves do arise in the theory of "random alms," 21 the agreement seems purely fortuitous so far as basic theoretical significance may be concerned.…”

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confidence: 82%

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Theoretical Basis of Indicator-Dilution Methods For Measuring Flow and Volume

Zierler

1962

Circulation Research

462

261

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confidence: 82%

“…( t -s -r ) g(r) drds. Jo J o (20) In our discussion of figure 8, we saw that, the concentration function in a recirculating system behaves like a damped oscillation and at any point in the system approaches i\\\ t/V T , where U' M is the rate of constant injection. Therefore, the asymptotic behavior of concentration at outflow is Lim C,,(t)…”

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confidence: 91%

Theoretical Basis of Indicator-Dilution Methods For Measuring Flow and Volume

Zierler

1962

Circulation Research

462

261

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“…In most organs, the intravascular transport process can be sufficiently modeled by a logarithmic normal density function: 3,12 g iv ͑t͒ ϭ 1…”

Section: Methods Of Measurement Of Cbfmentioning

confidence: 99%

Bedside Assessment of Cerebral Blood Flow by Double-indicator Dilution Technique

et al. 2000

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Background: Currently, quantitative measurement of global cerebral blood flow (CBF) at bedside is not widely performed. The aim of the present study was to evaluate a newly developed method for bedside measurement of CBF based on thermodilution in a clinical setting.Methods: The investigation was performed in 14 anesthetized patients before coronary bypass surgery. CBF was altered by hypocapnia, normocapnia, and hypercapnia. CBF was measured simultaneously by the Kety-Schmidt inert-gas technique with argon and a newly developed transcerebral double-indicator dilution technique (TCID). For TCID, bolus injections of ice-cold indocyanine green were performed via a central venous line, and the resulting thermo-dye dilution curves were recorded simultaneously in the aorta and the jugular bulb using combined fiberoptic thermistor catheters. CBF was calculated from the mean transit times of the indicators through the brain.Results: Both methods of measurement of CBF indicate a decrease during hypocapnia and an increase during hypercapnia, whereas cerebral metabolic rate remained unchanged. Bias between CBF TCID and CBF argon was ؊7.1 ؎ 2.2 (SEM) ml ⅐ min ؊1 ⅐

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“…For the implementation of the current algorithm the Log-norm distribution by Stow & Hentzel [40] was used for g(t) with mtt being the t* appearing in the exponent, following the argumentation of Hoeft [39] [ ] …”

Section: Appendix Amentioning

confidence: 99%

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

Mudra

Muroi

Niederer

et al. 2008

Opto-Electronics Review

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The cerebral blood flow (CBF) is an important vital parameter in neurointensive care. Currently, there is no non-invasive method for its measurement that can easily be applied at the bedside. A new tool to determine CBF is based on near-infrared spectroscopy (NIRS) applied together with indocyanine green (ICG) dye dilution. From a bilateral measurement on selected regions on the head of infrared (IR) absorption at various wavelengths during the dilution maneuver, the vascular perfusion characteristics of the two brain hemispheres can be determined in terms of mean transit time (mtt) of ICG, cerebral blood volume (CBV) and CBF.So far, on nine healthy volunteers, NIRS ICG dye dilution bihemispheric measurements were performed, which yielded to mtt given as median (range) of 9.3 s (5.1–16.3 s), CBV of 3.5 ml/100 g (1.7–4.1 ml/100 g), and CBF of 18.2 ml/(100 g×min) [11.1–48.6 ml/(100 g×min)]. Additionally, the blood flow index (BFI) was calculated with BFI= 13.8 mg/(100 g×s) [6.6–15.2 mg/(100 g×s)]. The Spearman rank correlation coefficient between CBF and BFI was RS = 0.76. However, as the Bland & Altman plot between CBFNIRS and the CBFBFI documents, the limits of agreement are rather wide (21.9±6.7). Under physiological conditions in healthy volunteers, no differences could be detected between the hemispheres.

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An Empirical Formula for Indicator-Dilution Curves as Obtained in Human Beings

Cited by 56 publications

References 0 publications

Theoretical Basis of Indicator-Dilution Methods For Measuring Flow and Volume

Theoretical Basis of Indicator-Dilution Methods For Measuring Flow and Volume

Bedside Assessment of Cerebral Blood Flow by Double-indicator Dilution Technique

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

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