<i>Aloe vera</i>extract activity on human corneal cells

Woźniak, Anna; Paduch, Roman

doi:10.3109/13880209.2011.579980

Cited by 30 publications

(23 citation statements)

References 33 publications

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“…Many Aloe species are highly decorative and are valued by collectors of succulents (Ma et al, 2010). Some species, especially A. vera L. are purported to have medicinal properties (Eriko et al, 2012;Woźnik and Paduch, 2012). Other uses of aloe include their role in alternative medicines and in home first aid (Yao et al, 2009;Dutta and Masakapalli, 2013).…”

Section: Introductionmentioning

confidence: 96%

Effects of silicon (Si) on growth, quality and ionic homeostasis of aloe under salt stress

Liu

2015

South African Journal of Botany

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The physiological characteristics of aloe irrigated with brackish water and the relationship with ameliorative effects of silicon (Si) nutrition were studied. Results of cultivation and analysis showed that 2.0 mmol · L −1 added Si significantly alleviated growth inhibition and quality reduction of aloe under 100 mmol · L −1 NaCl stress; added Si significantly reduced Na + content while increased K + content and K + /Na + ratio of salt stressed aloe plant, especially absorption and translocation selectivity of aloe root to K + and Na + were promoted, and ion homeostasis of aloe plant was kept well. Results of cross-sectional X-ray energy dispersive spectrum microanalysis of aloe root and leaf further confirmed the above findings. One of the mechanisms of silicon was its improvement to activity of plasma membrane H + -ATPase, tonoplast membrane H + -ATPase and H + -pyrophosphates of aloe root under salt stress.

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Section: Introductionmentioning

confidence: 96%

Effects of silicon (Si) on growth, quality and ionic homeostasis of aloe under salt stress

Liu

2015

South African Journal of Botany

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“…2a). The area of the scratch in the 0, 5, 10, 20, 40, 87.5, 175, and 250 lg/mL pretreatment groups changed by 27,32,34,31,29,33,33, and 27%, respectively. While all concentrations of aloe solution <250 lg/mL slightly increased the rate of cellular ingrowth, there were no significant changes detected.…”

Section: Corneal Epithelial Cellsmentioning

confidence: 97%

“…There are very few reports of aloe vera use in ophthalmology. A recent paper found no toxic effect on human corneal cells following in vitro treatment and no detrimental effects were observed after topical application of aloe in rabbits with experimentally induced corneal ulcers . This in vitro study was designed to (i) evaluate the effects of an aloe vera solution on the viability and wound healing response of corneal epithelial cells (CEC) and fibroblasts and (ii) evaluate the effects of aloe vera solution on collagenase and gelatinase activities.…”

Section: Introductionmentioning

confidence: 99%

Aloe vera: an in vitro study of effects on corneal wound closure and collagenase activity

Curto

Labelle

Chandler

2014

Veterinary Ophthalmology

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Purpose To evaluate the in vitro effects of an aloe vera solution on (i) the viability and wound healing response of corneal cells and (ii) the ability to alter collagenase and gelatinase activities. Methods Primary cultures of corneal epithelial cells and fibroblasts were prepared from grossly normal enucleated canine globes and treated with an aloe solution (doses ranging from 0.0-2 mg/mL). Cellular viability was evaluated using a colorimetric assay. A corneal wound healing model was used to quantify cellular ingrowth across a defect made on the confluent surface. Anticollagenase and antigelatinase activities were evaluated by incubating a bacterial collagenase/gelatinase with aloe solution (doses ranging from 0.0-500 lg/mL) and comparing outcome measures to a general metalloproteinase inhibitor, 1, 10-phenanthroline, and canine serum (doses ranging from 0.0-100%).Results None of the concentrations of aloe solution tested significantly affected the viability of corneal epithelial cells or fibroblasts. Concentrations ≤175 lg/mL slightly accelerated corneal epithelial cell wound closure; this change was not significant. Concentrations ≥175 lg/mL significantly (P ≤ 0.001) slowed the rate of corneal fibroblast wound closure, while aloe concentrations <175 lg/mL did not significantly alter fibroblast wound closure. Aloe solution did not alter the ability for collagenase to degrade gelatin or collagen Type I but increased the ability for collagenase to degrade Type IV collagen. Conclusions Although additional experiments are required, lower concentrations of aloe solution may be beneficial in healing of superficial corneal wounds to help decrease fibrosis and speed epithelialization. An increase in collagenase activity with aloe vera warrants further testing before considering in vivo studies.

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“…A. vera extract is used to restore the function of human corneal cells. [88] A. vera ethanol and ethyl acetate extracts are also used in eye drops to treat inflammations and other ailments of external parts of the eye such as the cornea.…”

Section: Anti-inflammatorymentioning

confidence: 99%

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Upadhyay¹

2018

IJGP

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The present review explains therapeutic and pharmaceutical potential of Aloe vera a well-known plant grows in semi-arid climate of tropical and subtropical regions. This article emphasizes important uses of A. vera constituents as dietary nutraceutical, medicinal, and therapeutic potential. Plant is cultivated for agricultural and medicinal and decoration purposes for indoors as a potted plant. Plant is a good depository of chemical constituents which display a very wide array of biological activities such as anticancer, antiparasitic, antidiabetic, anti-inflammatory, anti-arthritic, antiparasitic, antitumor, antioxidant, chemopreventive, hepatoprotective, and gastroprotective. Plant is used to prepare skin protective/care gels mainly for soothing, moisturizing, and wound healing. Thick watery plant sap works are added as key ingredient in many beauty products. Plant leaves are used to generate aroma, beverages, skin lotion, cosmetics, or ointments for minor burns. Plant contains vitamins, enzymes, minerals, sugars, lignin, saponins, salicylic acids, and amino acids as main ingredients. Plant is a good source of Vitamins A, C, and E, which are antioxidants. It also contains Vitamin B12, folic acid, and choline watery juicy of A. vera leaf which contains important minerals such as calcium, chromium, copper, selenium, magnesium, manganese, and potassium. Plant ingredients were found active against gingivitis, psoriasis, and used for herbal therapy in inflammatory bowel disease. A. vera contains important fatty acids mainly steroids such as cholesterol, campesterol, β-sitosterol, and lupeol. Aloin and emodin act as analgesics, antibacterials, and antivirals while lupeol shows antiseptic and analgesic properties. It also contains auxins and gibberellin hormones that help in wound healing and have anti-inflammatory action. Saponins that are the soapy substances display cleansing and antiseptic properties.

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Aloe veraextract activity on human corneal cells

Cited by 30 publications

References 33 publications

Effects of silicon (Si) on growth, quality and ionic homeostasis of aloe under salt stress

Effects of silicon (Si) on growth, quality and ionic homeostasis of aloe under salt stress

Aloe vera: an in vitro study of effects on corneal wound closure and collagenase activity

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