2023
DOI: 10.1161/atvbaha.123.318818
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Aggf1 Specifies Hemangioblasts at the Top of Regulatory Hierarchy via Npas4l and mTOR-S6K-Emp2-ERK Signaling

Zhongcheng Yang,
Di Guo,
Jinyan Zhao
et al.

Abstract: BACKGROUND: Hemangioblasts are mesoderm-derived multipotent stem cells for differentiation of all hematopoietic and endothelial cells in the circulation system. However, the underlying molecular mechanism is poorly understood. METHODS: CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 editing was used to develop aggf1 −/− and emp2… Show more

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