Agaricus bisporusAttenuates Dextran Sulfate Sodium-Induced Colitis

Abstract

Agaricus bisporus (white button mushroom, WBM) is widely consumed in most countries and is reported to have anti-inflammatory and antioxidant activities. However, little is known regarding its effects in dextran sulfate sodium (DSS)-induced colitis, which are related to dysfunction of intestinal immunity. The aim of the present study was to investigate the effects of WBMs in an animal model of DSS-induced colitis. Male, 4-week-old ICR mice (n=10 per group) were fed a normal diet with or without 10% WBM for 4 weeks, and colitis was induced by 3% DSS in drinking water for 7 days. WBMs prevented DSS-induced shortening of colon length (P=.033) and diminished diarrhea (P=.049) and gross bleeding (P=.001), resulting in a decreased disease activity index. Results of histological analysis showed that WBMs suppressed mucosal damage. In addition, WBMs attenuated the DSS-induced increase in myeloperoxidase activity (P=.012) and upregulation of proinflammatory cytokine tumor necrosis factor-α (P=.020) in the colon segment. Taken together, these findings suggest a possible role for the WBM as an immunomodulator that can prevent and/or treat ulcerative colitis.

Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill‐Based Mushroom Extract, AndoSan™, in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single‐Blinded Placebo‐Controlled Study

“…In agreement with our findings, it has been shown in mice with colitis, induced by dextran sulphate, that dietary intake of the mushroom Agaricus bisporus , rich in flavonoids, as well as ß ‐glucans from some yeasts , can have strong modulating effect on intestinal inflammation.…”

Study on the Protective Effect and Mechanism of Umbilicaria esculenta Polysaccharide in DSS-Induced Mice Colitis and Secondary Liver Injury

“…The polysaccharides can effectively regulate UC-induced increased intestinal permeability, dysregulation of inflammatory factors, and oxidative stress. Fungal polysaccharide, as a polysaccharide with the characteristics of “homology of medicine and food”, has attracted extensive research for its significant effect on UC and UC-related abnormal changes . A polysaccharide from the fungus Agaricus blazei showed significant alleviating effects on preventing UC-induced decrease in SOD and increase in MDA, suggesting that it can alleviate UC-induced oxidative stress .…”

Obtención de extractos metanólicos ricos en compuestos fenólicos a partir de hongos comestibles: valoración, "in vitro", de la actividad antioxidante y antiinflamatoria de los extractos

“…Así mismo, se demostró que la elevada actividad de la actividad mieloperoxidasa y la sobreproducción de TNF-α, que tenían lugar tras la inducción de la colitis, quedaban atenuados en aquellos animales alimentados con A. bisporus. Dicha actividad antiinflamatoria se relacionó con la capacidad antioxidante que el hongo mostró, atribuyéndose ambos efectos, en gran parte, al contenido de compuestos fenólicos del hongo (Um, Park et al 2014).…”