<i>Active for Life</i>
 After Cancer: a randomized trial examining a lifestyle physical activity program for prostate cancer patients

Taylor, Cindy L. Carmack; deMoor, Carl; Smith, Murray; Dunn, Andrea L.; Basen-Engquist, Karen; Nielsen, Ingrid; Pettaway, Curtis A.; Sellin, Rena V.; Massey, P; Gritz, Ellen R.

doi:10.1002/pon.1023

Cited by 129 publications

(117 citation statements)

References 68 publications

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“…However, the lack of decline in physical function and body composition variables noted above 119 suggest that lifestyle guidelines that focus on increasing physical activity might be considered as a minimal dose.…”

Section: Adt: Body Composition and Physical Function Tw Storer Et Al 214mentioning

confidence: 99%

“…25 A number of RCT in men with PCa receiving androgen suppression have shown the value of well-designed exercise training programs. These studies have demonstrated significant improvements in muscle performance, 37,92,117 physical function 37,92,118,119 and body composition 37,120 that occurred after as little as 12 weeks of training. Table 4 summarizes the efficacy of exercise training from five RCT, two uncontrolled trials and one small non-randomized pilot study in men undergoing androgen suppression therapy.…”

Section: Changes With Exercise Trainingmentioning

confidence: 99%

“…36,118,119 One uncontrolled 12-week study requiring 3-5 day week 21 walking and light resistance exercise plus biweekly group sessions showed statistically significant changes in 6-MWT (112%) and BMI (11%) in men undergoing ADT. 118 The 63-m improvement in 6-MWT is clinically meaningful.…”

Section: Adt: Body Composition and Physical Function Tw Storer Et Al 214mentioning

confidence: 99%

“…One RCT evaluated the effectiveness of a 6-month group-based lifestyle physical activity program (Project Active 121 ) in men who had undergone 33 months of continuous ADT. 119 An educational support group controlling for group and facilitator support provided in the lifestyle program, and a standard care group were included. After 6 and 12 months of the program, no differences were observed between groups for physical activity, self-reported physical functioning (SF-36), 6-min walk distance or measures of body composition.…”

Section: Adt: Body Composition and Physical Function Tw Storer Et Al 214mentioning

confidence: 99%

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Muscle function, physical performance and body composition changes in men with prostate cancer undergoing androgen deprivation therapy

Storer¹,

Miciek²,

Travison³

2012

Asian J Androl

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Prostate cancer (PCa) is the most common visceral malignancy in men with androgen deprivation therapy (ADT) the preferred therapy to suppress testosterone production and hence tumor growth. Despite its effectiveness in lowering testosterone, ADT is associated with side effects including loss of muscle mass, diminished muscle strength, decrements in physical performance, earlier fatigue and declining quality of life. This review reports a survey of the literature with a focus on changes in muscle strength, physical function and body composition, due to short-term and long-term ADT. Studies in these areas are sparse, especially well-controlled, prospective randomized trials. Cross-sectional and longitudinal data (up to 2 years) for men with PCa treated with ADT as well as patients with PCa not receiving ADT and age-matched healthy men are presented when available. Based on limited longitudinal data, the adverse effects of ADT on muscle function, physical performance and body composition occur shortly after the onset of ADT and tend to persist and worsen over time. Exercise training is a safe and effective intervention for mitigating these changes and initial guidelines for exercise program design for men with PCa have been published by the American College of Sports Medicine. Disparities in study duration, types of studies and other patient-specific variables such as time since diagnosis, cancer stage and comorbidities may all affect an understanding of the influence of ADT on health, physical performance and mortality. Keywords: androgen deprivation therapy; androgen suppression; exercise prescription; exercise training; functional assessment; lean body mass; older men; prostate cancer INTRODUCTION Prostate cancer (PCa) is the most common visceral malignancy in men.1 Since the tumor is initially testosterone dependent, androgen deprivation therapy (ADT) is the preferred modality to suppress testosterone production in men with this disease. ADT has been extensively studied with surgical and chemical castration achieved via bilateral orchiectomy, use of a gonadotropin hormone-releasing hormone (GnRH) agonist or anti-androgens. Annually, about 500 000 men in the United States are treated with GnRH agonists.2 Though their effectiveness in lowering serum testosterone to castrate levels is well established, side effects are common.Testosterone and its metabolites are essential for the maintenance of muscle mass and bone mineral content. Body composition changes in men undergoing ADT place them at increased risk not only for diminished physical capacity, but also for coronary artery disease, type II diabetes and the metabolic syndrome, 3 though a recent meta-analysis suggests no increase in cardiovascular mortality. 4 In addition, ADTassociated decreases in muscle and bone mass are thought to be associated with increased fracture risk, diminished muscle strength, decrements in physical performance, earlier fatigue and declining quality of life (Figure 1).This narrative review focuses on changes in muscle strength, physi...

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Section: Adt: Body Composition and Physical Function Tw Storer Et Al 214mentioning

confidence: 99%

Section: Changes With Exercise Trainingmentioning

confidence: 99%

Section: Adt: Body Composition and Physical Function Tw Storer Et Al 214mentioning

confidence: 99%

Section: Adt: Body Composition and Physical Function Tw Storer Et Al 214mentioning

confidence: 99%

See 2 more Smart Citations

Muscle function, physical performance and body composition changes in men with prostate cancer undergoing androgen deprivation therapy

Storer¹,

Miciek²,

Travison³

2012

Asian J Androl

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show abstract

“…This can have long-lasting effects; in one intervention study, social support was found to be such a valued part of a group exercise programme for breast cancer survivors that the participants arranged to exercise together weekly following the completion of the intervention (Campbell et al, 2005). However, studies providing physical activity interventions with breast cancer survivors have not all demonstrated the importance of social support -for example, Taylor et al (2006) found that group physical activity education or cognitive-behavioural sessions relating to physical activity did not improve levels of social support. However, the participants in this group did not engage in actual physical activity together and it may be that the collective action element that cancer survivors appear to desire may play an important role in bolstering this support.…”

Section: Individual Versus Group Basedmentioning

confidence: 99%

Physical Activity and Cancer

Bk¹,

Ih²,

Rohde³

2013

Encyclopedia of Behavioral Medicine

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It is widely accepted that physical activity is important for physical functioning and well-being, and as such the promotion of active lifestyles is becoming increasingly significant in public health policy both in the UK and worldwide. Sedentary lifestyles have been associated with increased risk of obesity and preventable disease including diabetes, coronary heart disease and some cancers. With regards cancer specifically, this chapter will provide a brief overview on current opinions on the link between physical activity and cancer prevention.The published evidence focuses both on primary and secondary prevention. More recent evidence has investigated the use of physical activity in secondary prevention for those who have been diagnosed with cancer and proposed a link between physical activity, morbidity and mortality in those with cancer. The evidence-base for secondary prevention is more limited. Nevertheless, studies to date have indicated that physical activity can improve both physical functioning and psychological outcomes in cancer survivors, and significantly improve quality of life.The exact nature of those interventions which confer the most positive effects is less well-established, and there is a current lack of consensus on the most appropriate type, intensity and duration of activity for people with cancer. It has not yet been wellestablished as to which stage of the treatment programme physical activity should be encouraged (during or following treatment) or the most appropriate length of time during which structured physical activity interventions should be delivered to achieve beneficial results.These factors will be discussed in this chapter, and barriers to engaging in physical activity for those with a diagnosis of cancer will be considered. The chapter will conclude with a summary of key findings and the potential for further research.

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Exercise interventions on health-related quality of life for cancer survivors

Mishra

Scherer

Geigle

et al. 2012

Cochrane Database of Systematic Reviews

503

275

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This systematic review indicates that exercise may have beneficial effects on HRQoL and certain HRQoL domains including cancer-specific concerns (e.g. breast cancer), body image/self-esteem, emotional well-being, sexuality, sleep disturbance, social functioning, anxiety, fatigue, and pain at varying follow-up periods. The positive results must be interpreted cautiously due to the heterogeneity of exercise programs tested and measures used to assess HRQoL and HRQoL domains, and the risk of bias in many trials. Further research is required to investigate how to sustain positive effects of exercise over time and to determine essential attributes of exercise (mode, intensity, frequency, duration, timing) by cancer type and cancer treatment for optimal effects on HRQoL and its domains.

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Active for Life After Cancer: a randomized trial examining a lifestyle physical activity program for prostate cancer patients

Abstract: Results suggest a lifestyle program focusing on cognitive-behavioral skills training alone is insufficient for promoting routine physical activity in these patients.

Cited by 129 publications

References 68 publications

Muscle function, physical performance and body composition changes in men with prostate cancer undergoing androgen deprivation therapy

Muscle function, physical performance and body composition changes in men with prostate cancer undergoing androgen deprivation therapy

Physical Activity and Cancer

Exercise interventions on health-related quality of life for cancer survivors

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