<i>Actinobacillus actinomycetemcomitans</i> in a rural adult population in southern Thailand

Dahlén, Gunnar; Widar, Fredrik; Teanpaisan, Rawee; Papapanou, Panos N.; Bælum, Vibeke; Fejerskov, O.

doi:10.1034/j.1399-302x.2002.170301.x

Cited by 42 publications

(40 citation statements)

References 45 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Not only various techniques but also ethnic and/or geographical factors may partly explain different observations. For example, the present and above-mentioned Western carriage rates of A. actinomycetemcomitans are seemingly low compared to much higher rates reported for rural populations in Far Eastern countries (6,21,28).…”

Section: Discussionmentioning

confidence: 88%

Population-Based Study of Salivary Carriage of Periodontal Pathogens in Adults

Könönen¹,

et al. 2007

View full text Add to dashboard Cite

Large, general population-based data on carriage rates of periodontal pathogens hardly exist in the current literature. The objectives of the present study were to examine the salivary detection of Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans, Campylobacter rectus, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis, and Treponema denticola in a representative sample of the adult population living in southern Finland and to clarify which determinants are associated with the presence of these pathogens in saliva. 16S rRNA-based PCR methods with species-specific primers were employed to determine the presence of the six target bacteria in stimulated saliva samples, which were available from 1,294 subjects aged >30 years. The age group, gender, level of education, marital status, smoking history, number of teeth, and number of teeth with deepened pockets were included in the statistical analysis. In general, the carriage of periodontal pathogens was common, since at least one of the examined pathogens was found in 88.2% of the subjects. In descending order, the total detection rates were 56.9%, 38.2%, 35.4%, 31.3%, 20.0%, and 13.9% for T. forsythensis, T. denticola, P. gingivalis, C. rectus, A. actinomycetemcomitans, and P. intermedia, respectively. Age per se was strongly associated with the carriage of P. gingivalis (P ‫؍‬ 0.000), and the level of education with that of T. denticola (P ‫؍‬ 0.000). There was an association between the number of teeth with deepened pockets and carriage of P. gingivalis (P ‫؍‬ 0.000), P. intermedia (P ‫؍‬ 0.000), T. denticola (P ‫؍‬ 0.000), and A. actinomycetemcomitans (P ‫؍‬ 0.004). The data suggest that distinct species have a different carriage profile, depending on variables such as age, educational level, and periodontal status.Periodontitis is characterized by local infection and inflammation of tooth-supporting tissues, leading to various degrees of periodontal attachment loss in affected teeth. Different forms of periodontitis are multifactorial diseases where microorganisms present in dental biofilms are involved. Etiologic bacteria of periodontal diseases typically include gram-negative anaerobic bacteria: among those, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis (formerly Bacteroides forsythus), and Treponema denticola are strictly anaerobic and Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans and Campylobacter rectus are facultative/microaerobic (2,4,13,33). Several demographic and behavioral characteristics, such as race, age, gender, and smoking, as well as socioeconomic status, appear to be related to the prevalence of periodontitis, as shown in different populations worldwide (1). It may be expected that similar factors relate to the carriage pattern of periodontitis-associated microorganisms in similar ways as well. For example, the cumulative increase of periodontitis due to aging could be reflected by the increasing carriage of periodontal pathogen(s). As far as we know, natural car...

show abstract

Section: Discussionmentioning

confidence: 88%

Population-Based Study of Salivary Carriage of Periodontal Pathogens in Adults

Könönen¹,

et al. 2007

View full text Add to dashboard Cite

show abstract

“…In Europe, Sanz et al (14) found a significant difference between the presence of Aa in periodontal patients from Spain (2.3%) and The Netherlands (23.3%). Dahlen et al (11) and Mombelli et al (15) found prevalences of 88% and 63%, in Southern Thailand and China, respectively. These authors suggest that Aa is a common constituent of the normal microbiota in these populations.…”

Section: Discussionmentioning

confidence: 99%

“…These characteristics have a relationship with both the prevalence of periodontal diseases and the pathogens related to them (9)(10)(11)(12)(13)(14)(15). Furthermore, studies about the transmission of periodontopathogens are valuable to elucidate its significance as a risk factor for the establishment of periodontal diseases and to search available ways for their prevention (16).…”

Section: Introductionmentioning

confidence: 99%

Transmission of Aggregatibacter actinomycetemcomitans between Brazilian women with severe chronic periodontitis and their children

et al. 2007

View full text Add to dashboard Cite

This study evaluated the transmission of Aggregatibacter actinomycetemcomitans (Aa) in women with severe chronic periodontitis and their children. Thirty women (mean age = 36.1±6.0 years) who were mothers of at least one child aged 7 to 16 years were enrolled. In order to investigate mother-child transmission of Aa, the children were also evaluated when their mothers were colonized by the bacterium. Subgingival plaque samples of each woman were collected from 3 sites (mean probing depth of 7.3±1.2 mm and mean clinical attachment level of 7.9±1.5 mm) and pooled in reduced transport fluid (RTF). These samples were processed, inoculated onto TSBVagar selective medium and incubated at 37°C in microaerophilic atmosphere for 5 days. Aa was identified on the basis of colony morphology, Gram staining, catalase and oxidase reactions. Aa was found in 8 out of 30 women. Therefore, 8 children from these women (mean age= 12 ± 3.7 years) were evaluated, but Aa was found only in 2 of them. Aa strains of the two mother-child pairs were evaluated by arbitrarily-primed polymerase chain reaction (AP-PCR), although it was not found similarity between the amplitypes of each pair. No Aa transmission was found between Brazilian women with severe chronic periodontitis and their children.

show abstract

“…However, the prevalence and proportion of these species in the subgingival microbiota may vary (15,26). For instance, evidence has demonstrated a lower prevalence of Actinobacillus actinomycetemcomitans in the European and American than in the Asian population (1,4,9). Umeda et al (36) also identified race or ethnicity as a potential risk factor for harboring oral A. actinomycetemcomitans.…”

Section: Introductionmentioning

confidence: 97%

“…Many studies have attempted to clarify the relationship between a specific bacterium and/or a group of microorganisms and the pathogenesis of periodontitis. These data were originated in several parts of the world, including Europe, Africa, Asia, North and South America (5,8,9,15,23,25,26,31,33). A general finding is that, even in different populations, the same periodontal species are found in sites or individuals with periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of leukotoxic genotypes of Actinobacillus actinomycetemcomitans in Brazilians with chronic periodontitis

Rosalem¹,

Andrade²,

Colombo³

2006

Braz. J. Microbiol.

View full text Add to dashboard Cite

Actinobacillus actinomycetemcomitans is considered a major etiologic agent of aggressive periodontitis but this species has also been associated with other forms of periodontal disease. Further, highly leukotoxic strains are related to severity of disease. This investigation determined the prevalence of A. actinomycetemcomitans and the occurrence of the leukotoxin gene 530-bp deletion in Brazilian subjects with chronic periodontitis. Twenty periodontally healthy and 20 chronic periodontitis subjects were selected. Fullmouth clinical examination was carried out at 6 sites/tooth. Subgingival biofilm samples were collected from the 3 deepest sites and 3 healthy sites from periodontitis subjects, as well as from 3 sites of individuals with periodontal health. A. actinomycetemcomitans and the genetic deletion were determined by the polymerase chain reaction. Significant differences were sought by Mann-Whitney, Chi-square, and Wilcoxon sign tests. Periodontitis subjects presented a higher prevalence (75%) of A. actinomycetemcomitans than individuals with health (45%) (p = 0.053). A mean frequency of 57.5% of A. actinomycetemcomitans -positive sites was observed in the periodontitis group. Of those, 75% were diseased, whereas 40% were healthy sites (p = 0.0001). Healthy subjects showed a mean frequency of 35% of positive sites. In contrast, the genetic deletion was detected only in 4 diseased sites from 2 chronic periodontitis patients. A high prevalence of A. actinomycetemcomitans was observed in Brazilians with chronic periodontitis. However, the leukotoxin gene 530-bp deletion was rarely detected in the subgingival biofilm of these subjects.

show abstract

Actinobacillus actinomycetemcomitans in a rural adult population in southern Thailand

Cited by 42 publications

References 45 publications

Population-Based Study of Salivary Carriage of Periodontal Pathogens in Adults

Population-Based Study of Salivary Carriage of Periodontal Pathogens in Adults

Transmission of Aggregatibacter actinomycetemcomitans between Brazilian women with severe chronic periodontitis and their children

Prevalence of leukotoxic genotypes of Actinobacillus actinomycetemcomitans in Brazilians with chronic periodontitis

Contact Info

Product

Resources

About