ABCC2 Polymorphisms and Haplotype are Associated with Drug Resistance in Chinese Epileptic Patients

Abstract

ABCC2-24C>T, 3972C>T polymorphisms and one ABCC2 haplotype is associated with AED resistance; ABCC2 1249G>A and ABCB1 3435C>T polymorphisms are not associated with AED resistance in our study. These data suggest that ABCC2 polymorphisms and haplotype may affect the response of antiepileptic drugs.

ABCB1 G2677T/A polymorphism is associated with the risk of drug-resistant epilepsy in Asians

“…for pharmacoresistance (Löscher and Potschka, 2002). A previous meta-analysis by Qu focused on the relation between ABCC2 polymorphisms and the risk of drug-resistant epilepsy in the Chinese population, and it concluded that ABCC2 C-24T and C3972T polymorphisms are associated with resistance to AEDs (Qu et al, 2012). This suggests that polymorphisms in genes encoding multidrug transporters may affect response to antiepileptic drugs.…”

Association between the polymorphisms in the ATP-binding cassette genes ABCB1 and ABCC2 and the risk of drug-resistant epilepsy in a Chinese Han population

“…Several previous studies have reported an association between the ABCC2 rs2273697 and rs717620 polymorphisms and risk of drug-resistant epilepsy, but with conflicting results (Seo et al, 2008;Kwan et al, 2011;Hilger et al, 2012;Qu et al, 2012;Sporis et al, 2013;Subenthiran et al, 2013a;Escalante-Santiago et al, 2014;Ma et al, 2014). Qu et al (2012) revealed a significant association between the ABCC2 rs2273697 and rs717620 polymorphisms and resistance to antiepileptic drugs in Chinese epileptic patients.…”

“…Qu et al (2012) revealed a significant association between the ABCC2 rs2273697 and rs717620 polymorphisms and resistance to antiepileptic drugs in Chinese epileptic patients. Subenthiran et al (2013a) indicated a correlation between the ABCC2 rs2273697 and rs717620 polymorphisms and resistance to antiepileptic drugs in a study comprising 152 and 162 anti-epileptic drug-responsive and -resistant patients, respectively (Subenthiran et al, 2013a).…”

Common variants of ATP1A3 but not ATP1A2 are associated with Chinese genetic generalized epilepsies

“…The patients were considered to be drug-responsive if they had not experienced any type of seizures for a minimum of 1 year after receiving AEDs. Drug resistance was defined as having at least four seizures during the previous year while trying at least three antiepileptic medications at maximal tolerated doses [31,32]. This study was performed according to the principles of the Declaration of Helsinki (revision of Edinburgh 2000).…”