<i>A New Approach to Control of Anemia</i> in “At Risk” Infants and Children Around the World 2004 Ryley-Jeffs Memorial Lecture

Zlotkin, Stanley

doi:10.3148/65.3.2004.136

Cited by 7 publications

(1 citation statement)

References 9 publications

(6 reference statements)

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“…Venous blood was obtained from the mothers at the time of delivery and from the infants at 6 mo of age to assess iron status (15). In the Ghana study, infants 6 mo old were randomly assigned to 1 of 3 daily micronutrient supplement groups: I) Sprinkles (Ped-Med Ltd, Toronto, Canada; 12.5 mg elemental Fe/d as ferrous fumarate) (16); 2) Nutritabs (Laboratoires Pharmaceutiques Rodael SA, Bieme, France; 9 mg elemental Fe/d as ferrous sulfate) (17); or 3) Nutributter (Nutriset SA. Malaunay, France; 9 mg elemental Fe/d as ferrous sulfate) (18).…”

Section: Methodsmentioning

confidence: 99%

Comparison of plasma ferritin concentration with the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials

Yang

Dewey

Lönnerdal

et al. 2008

The American Journal of Clinical Nutrition

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Background: Efforts to develop global programs for the control of iron deficiency require simple, low-cost, and accurate indicators of iron status. Objective: We aimed to compare estimates of body iron (BI) stores, as calculated from either plasma ferritin concentration alone (BIferritin) or the ratio of plasma transferrin receptor (TfR) to ferritin (BI-TfRlferritin). Design: Data were analyzed from 4 previously completed, randomized intervention trials that enrolled infants, schoolchildren, or pregnant women (total n = 1189, after excluding subjects with elevated C-reactive protein). Results: The correlation coefficients between BI-ferritin and BI-TfRiferritin were >0.95 for all studies. The kappa index ranged from 0.5 to 1.0. All of the sensitivities of BI-ferritin for identifying persons with low iron stores (defined as BI-TfRlferritin <0 mg/kg body wt) were >0.90. All of the specificities were >0.90 except the study of pregnant women (specificity = 0.66). The effect sizes of iron intervention trials were significantly greater for change in iron reserves estimated by BI-TfR/ferritin than by BI-ferritin in 2 studies with larger effect sizes (1.11 compared with 1.00 and 1.56 compared with 1.44, respectively; P < 0.05) and I study with medium effect size (0.70 compared with 0.57; P < 0.05). However, there were no significant differences between estimates of these effect sizes for 1 study with a medium effect size and I study with a smaller effect size (0.78 compared with 0.83 and 0.37 compared with 0.35, respectively: P> 0.2). Conclusion: Plasma ferritin concentration alone provides a good approximation of total BI reserves, as estimated by BI-TfRiferritin, on the basis of high correlation, sensitivity, and specificity among nonpregnant persons with unelevated C-reactive protein.

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Section: Methodsmentioning

confidence: 99%

Comparison of plasma ferritin concentration with the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials

Yang

Dewey

Lönnerdal

et al. 2008

The American Journal of Clinical Nutrition

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Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Calabrese

Cornelius

Dinkova‐Kostova

et al. 2012

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

359

277

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Modulation of endogenous cellular defense mechanisms represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. This paper introduces the emerging role of exogenous molecules in hormetic-based neuroprotection and the mitochondrial redox signaling concept of hormesis and its applications to the field of neuroprotection and longevity. Maintenance of optimal long-term health conditions is accomplished by a complex network of longevity assurance processes that are controlled by vitagenes, a group of genes involved in preserving cellular homeostasis during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Hsp70, the thioredoxin and the sirtuin protein systems. Dietary antioxidants, such as polyphenols and L-carnitine/acetyl-L-carnitine, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways, including vitagenes. Hormesis provides the central underpinning of neuroprotective responses, providing a framework for explaining the common quantitative features of their dose response relationships, their mechanistic foundations, their relationship to the concept of biological plasticity as well as providing a key insight for improving the accuracy of the therapeutic dose of pharmaceutical agents within the highly heterogeneous human population. This paper describes in mechanistic detail how hormetic dose responses are mediated for endogenous cellular defense pathways including sirtuin, Nrfs and related pathways that integrate adaptive stress responses in the prevention of neurodegenerative diseases. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease.

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Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

Calabrese

Cornelius

Dinkova‐Kostova

et al. 2010

Antioxidants & Redox Signaling

695

573

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Despite the capacity of chaperones and other homeostatic components to restore folding equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer and in metabolic and neurodegenerative diseases. Modulation of endogenous cellular defense mechanisms represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. This article introduces the concept of hormesis and its applications to the field of neuroprotection. It is argued that the hormetic dose response provides the central underpinning of neuroprotective responses, providing a framework for explaining the common quantitative features of their dose-response relationships, their mechanistic foundations, and their relationship to the concept of biological plasticity, as well as providing a key insight for improving the accuracy of the therapeutic dose of pharmaceutical agents within the highly heterogeneous human population. This article describes in mechanistic detail how hormetic dose responses are mediated for endogenous cellular defense pathways, including sirtuin and Nrf2 and related pathways that integrate adaptive stress responses in the prevention of neurodegenerative diseases. Particular attention is given to the emerging role of nitric oxide, carbon monoxide, and hydrogen sulfide gases in hormetic-based neuroprotection and their relationship to membrane radical dynamics and mitochondrial redox signaling.

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A New Approach to Control of Anemia in “At Risk” Infants and Children Around the World 2004 Ryley-Jeffs Memorial Lecture

Cited by 7 publications

References 9 publications

Comparison of plasma ferritin concentration with the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials

Comparison of plasma ferritin concentration with the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

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