<i>3111T/C CLOCK</i>GENE POLYMORPHISM IS NOT ASSOCIATED WITH SLEEP DISTURBANCES IN UNTREATED DEPRESSED PATIENTS

Serretti, Alessandro; Gaspar-Barba, Enrique; Calati, Raffaella; Cruz-Fuentes, Carlos; Gomez-Sanchez, Ariadna; Pérez‐Molina, Amado; Ronchi, Diana De

doi:10.3109/07420521003663785

Cited by 34 publications

(16 citation statements)

References 65 publications

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“…The rs1801260 single-nucleotide polymorphism (SNP) is the first human clock gene variation reported to affect human circadian rhythms (Katzenberg et al, 1998); it is a variation that occurs in the 3' untranslated region (UTR) (Robilliard et al, 2002). This SNP was associated with sleep disturbances in subjects affected by major depressive disorder or bipolar disorder ; however, Robilliard et al (2002), studying sleep patterns in normal subjects, did not find any association with rs1801260, and our team as well recently reported no associations in untreated depressed patients (Serretti et al, 2010). Besides, the rs1801260 has been studied in association with mood disorders (as a whole) (Bailer et al, 2005;Desan et al, 2000;Johansson et al, 2003) with negative results.…”

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confidence: 85%

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T3111c Clock Single Nucleotide Polymorphism and Mood Disorders: A Meta-Analysis

Calati

Gaspar-Barba²,

Yukler³

et al. 2010

Chronobiology International

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It has been hypothesized that abnormalities in the molecular clock underlie the development of mood disorders, in the direction of higher prevalence in individuals with a reduced flexibility to adapt to important regulations of mood in response to changes in seasons, stress levels, sleep schedules, and time zones. In particular, a T/C change (rs1801260) at the 3111 position of the circadian locomotor output cycles kaput (CLOCK) gene has been explored in psychiatry disorders. This meta-analysis has been undertaken to investigate the association between rs1801260 and both mood disorders and depression severity, shedding light on previous controversial results and providing better power to detect smaller effect sizes. PubMed and ISI databases were searched for studies focused on the association between rs1801260 and mood disorders spectrum. Quality of studies was assessed. We found no association between CLOCK genotypes and mood disorders, even when we separately investigated ethnical homogeneous or unipolar disorder studies. No association was found regarding severity of depression either. The methodological quality of the studies has been found to be medium-high. Our meta-analysis shows no association between rs1801260 and mood disorders (as a complete phenotype) or depression severity and points out the necessity of further research in order to better understand the underlying biological machinery of circadian dysfunction in subjects affected by mood disorders.

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confidence: 85%

“…The search was not limited by language or publication status. Additionally, we included data from our recent article (Serretti et al, 2010). Searches are available upon request from the corresponding author.…”

Section: Search Strategymentioning

confidence: 99%

T3111c Clock Single Nucleotide Polymorphism and Mood Disorders: A Meta-Analysis

Calati

Gaspar-Barba²,

Yukler³

et al. 2010

Chronobiology International

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“…CT have also been studied at the genetic level to determine whether clock genes are involved in the link between CT and mental disorders, but controversial results have been observed Osland et al, 2011;Serretti et al, 2010). The results from genetic studies suggest the polymorphism may not be the only factor responsible for the association between mental disorders and CT.…”

Section: Psychiatric Disorders: Clinical Implicationsmentioning

confidence: 99%

Circadian Typology: A Comprehensive Review

Adán¹,

Archer²,

Hidalgo³

et al. 2012

Chronobiology International

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The interest in the systematic study of the circadian typology (CT) is relatively recent and has developed rapidly in the two last decades. All the existing data suggest that this individual difference affects our biological and psychological functioning, not only in health, but also in disease. In the present study, we review the current literature concerning the psychometric properties and validity of CT measures as well as individual, environmental and genetic factors that influence the CT. We present a brief overview of the biological markers that are used to define differences between CT groups (sleep-wake cycle, body temperature, cortisol, and melatonin), and we assess the implications for CT and adjustment to shift work and jet-lag. We also review the differences between CT in terms of cognitive abilities, personality traits and the incidence of psychiatric disorders. When necessary, we have emphasized the methodological limitations that exist today and suggested some future avenues of work in order to overcome these. This is a new field of interest to professionals in many different areas (research, labor, academic, and clinical) and this review provides a state of the art discussion to allow professionals to integrate chronobiological aspects of human behavior into their daily practice.

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“…see 93,94,[95][96][97][98] Other studies have also investigated genes previously found to be associated with psychopathology in relation to sleep disturbances. For example, one study recently found an association between a polymorphism of the GRIA3 gene and sleep duration, which has previously been associated with depression.…”

Section: Specifying Genes and Environmentsmentioning

confidence: 99%

Quantitative genetic research on sleep: A review of normal sleep, sleep disturbances and associated emotional, behavioural, and health-related difficulties

Barclay¹,

Gregory²

2013

Sleep Medicine Reviews

116

107

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Over the past 50 years, well over 100 twin studies have focussed on understanding factors contributing to variability in normal sleep-wake characteristics and sleep disturbances.Whilst we have gained a great deal from these studies, there is still much to be learnt. Twin studies can be used in multiple ways to answer questions beyond simply estimating heritability. This paper provides a comprehensive review of some of the most important findings from twin studies relating to sleep to date, with a focus on studies investigating genetic and environmental influences contributing to i) objective and subjective measures of normal sleep characteristics (e.g. sleep stage organisation, sleep quality); as well as sleep disturbances and disorders such as dyssomnias (e.g. insomnia, narcolepsy) and parasomnias (e.g. sleepwalking, bruxism); ii) the persistence of sleep problems from childhood to adulthood, and the possibility that the aetiological influences on sleep change with age; iii) the associations between sleep disturbances, emotional, behavioural and health-related problems; and iv) processes of gene-environment correlation and interaction. We highlight avenues for further research, emphasising the need to further consider the aetiology of longitudinal associations between sleep disturbances and psychopathology; the genetic and environmental overlap between sleep and numerous phenotypes; and processes of geneenvironment interplay and epigenetics.

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3111T/C CLOCKGENE POLYMORPHISM IS NOT ASSOCIATED WITH SLEEP DISTURBANCES IN UNTREATED DEPRESSED PATIENTS

Cited by 34 publications

References 65 publications

T3111c Clock Single Nucleotide Polymorphism and Mood Disorders: A Meta-Analysis

T3111c Clock Single Nucleotide Polymorphism and Mood Disorders: A Meta-Analysis

Circadian Typology: A Comprehensive Review

Quantitative genetic research on sleep: A review of normal sleep, sleep disturbances and associated emotional, behavioural, and health-related difficulties

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