HZI Systems for EEG Parametrization and Classification of Psychotropic Drugs

Tm, Itil; Dm, Shapiro; Wm, Herrmann; Schulz, William E.; Morgan, Hiram

doi:10.1055/s-0028-1094590

Cited by 37 publications

(15 citation statements)

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“…Interestingly, we did not find a positive association between slow ß and the mean dose of benzodiazepines as previously reported [34,35], but there was an increase in power in the and ß band in the frontal regions relatively to the occipital brain areas.…”

Section: Discussionsupporting

confidence: 62%

Relationship between Power Spectra of the Awake EEG and Psychomotor Activity Patterns Measured by Short-Term Actigraphy

et al. 2003

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Actigraphy is a quantitative method for the measurement of motor activity. In the present study, actigraphy was used to examine psychomotor correlates of brain activity. Thirty-four psychiatric patients (17 males and 17 females) with different diagnoses participated in this investigation. Directly after EEG recording, motor activity was measured with a wrist actimeter for 15 min in patients in the sitting position. The EEG was quantified by spectrum analysis, and the power spectra as well as other EEG-derived variables were correlated with actigraphic parameters. Occipital and temporoparietal β1 power was statistically significantly higher in patients with higher activity scores and lower in those with a high density of sleep (SB) or wake bouts (WB). A high density of SB or WB was also positively correlated with higher mean α power. Immobile phases measured by actigraphy were positively associated with occipital α and with frontal/frontopolar δ activity, preferentially on the side of the left hemisphere. Our results, while preliminary, suggest that short-term actigraphy may be apt to reflect central nervous system arousal.

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Section: Discussionsupporting

confidence: 62%

Relationship between Power Spectra of the Awake EEG and Psychomotor Activity Patterns Measured by Short-Term Actigraphy

et al. 2003

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“…From the old profiles [Itil et al, 1968[Itil et al, , 1979Fink, 1963] it can be seen that above all the slow beta increases under benzodiazepines. This increase has been described as beta spindles in the 14-to 20-Hz range.…”

Section: Diazepammentioning

confidence: 99%

“…1963;Itil et al, , 1979], Bente [1964,1977] labeled this phenomenon a 'dissociative vigilance shift' and de veloped a theory that the neurophysiological correlate of depression was a disorder of vigilance with too great fluctuations of vigilance transgressing the physiological limits of tolerance. Yet we now find a reduction in the fast beta range, i.e., essentially a destruction of alpha and an increase of slow frequencies.…”

Section: Amitriptylinementioning

confidence: 99%

Psychotropic Drug Profiles: Comparisons by Topographic Maps of Absolute Power

Coppola

Herrmann

1987

Neuropsychobiology

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In a double-blind fourfold crossover design, 11 subjects were randomly assigned to placebo, 10 mg diazepam, 75 mg amitriptyline, and 75 mg chlorpromazine. During a simple vigilance task, 12 midline and left hemisphere leads were recorded before and 3 h after drug administration. The EEG was quantified by spectrum analysis, the topographic structure displayed by brain mapping techniques, and the results compared with earlier studies which used the same design and drugs. Diazepam showed the expected increase in beta; however, fast beta was increased as much as slow beta. Amitriptyline showed an increase of slow wave power and a reduction of alpha. In contrast to earlier studies, a decrease of fast beta was found. In addition, the spatial pattern of alpha changed from an occipital to a parietal maximum. Chlorpromazine showed an increase in the theta band. In occipital regions, there was a small decrease of fast beta; however, centrally there was an increase of both slow and fast beta. These results were confirmed by a multivariate analysis of variance.

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“…It has been argued that if a drug directly affects brain functions, this should be detectable after a single dose [Itil, 1974], and that a compound with psychotropic properties induces statistically significant effects on brain functions reflected by clectrophysiological parameters [Itil, 1976: Saletu, 1989], Such single dose effects of pira cetam on electrical brain activity have been shown by Sannita et al [1985] and Kinoshita et al [1987] as global changes of EEG power similar to other nootropics [Saletu. 1989;Itil et al, 1979]. Although these results indicate direct piracetam effects on brain activity, they do not prove specific effects on cognitive functions.…”

Section: Introductionmentioning

confidence: 64%

Single Doses of Piracetam Affect 42-Channel Event-Related Potential Microstate Maps in a Cognitive Paradigm

Michel

Lehmann²

1993

Neuropsychobiology

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We examined whether a single administration of piracetam produces dose-dependent effects on brain functions in healthy young men. In 6 subjects, 42-channel event-related EEG potential maps (ERP) were recorded during a task requiring subjects to watch single digits presented in a pseudorandom order on a screen and to press a button after all triplets of three consecutive odd or even digits. The ERP maps to the three digits of the correctly detected triplets were analyzed in terms of their mapped ERP field configuration (landscape). Different landscapes of the maps indicate different configuration of the activated neural population and therefore reflect different functional microstates of the brain. In order to identify these microstates, adaptive segmentation of the map series based on their landscapes was done. Nineteen time segments were found. These segments were tested for direct effects on brain function of three single doses of piracetam (2.9, 4.8 or 9.6 g) and a placebo given double-blind in balanced order. Piracetam mainly affected the map landscape of the time segments following the triplet’s last digit. U-shaped dose-dependent effects were found; they were strongest after 4.8 g piracetam. Since these particular ERP segments are recognized to be strongly correlated to cognitive functions, the present findings suggest that single medium doses of piracetam selectively activate differently located or oriented neurons during cognitive steps of information processing.

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HZI Systems for EEG Parametrization and Classification of Psychotropic Drugs

Cited by 37 publications

References 0 publications

Relationship between Power Spectra of the Awake EEG and Psychomotor Activity Patterns Measured by Short-Term Actigraphy

Relationship between Power Spectra of the Awake EEG and Psychomotor Activity Patterns Measured by Short-Term Actigraphy

Psychotropic Drug Profiles: Comparisons by Topographic Maps of Absolute Power

Single Doses of Piracetam Affect 42-Channel Event-Related Potential Microstate Maps in a Cognitive Paradigm

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