Hystéroscopie systématique avant fécondation in vitro

Feghali, Jawad; Bakar, J; Mayenga, J.-M.; Segard, L; Hamou, J.; Driguez, P; Belaïsch-Allart, J.

doi:10.1016/s1297-9589(03)00007-9

Cited by 54 publications

(9 citation statements)

References 10 publications

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“…Since CE has been reported to cause recurrent implantation failure after IVF and spontaneous abortion [9, 44], many researchers have attempted to determine why CE resulted in poor outcomes of the implantation process. A recent report showed that altered uterine contractility in CE patients leads to uterine dysperistalsis, which may be a significant cause of infertility [45].…”

Section: Discussionmentioning

confidence: 99%

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Chronic endometritis modifies decidualization in human endometrial stromal cells

Kimura

Zheng

et al. 2017

Reprod Biol Endocrinol

122

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BackgroundChronic endometritis (CE) is a continuous inflammation of uterine endometrium, and it is usually symptomless. As CE has been thought not to affect the reproductive status and general health of affected women, its significance has not been explored. However, recent studies have shown that CE is related with repeated implantation failures after in vitro fertilization-embryo transfer, unexplained infertility, and recurrent miscarriages. As decidua differentiates to support the implantation process and maintains the pregnancy, we hypothesized that CE may influence the process of decidualization.MethodsSeventeen patients were employed in the experiment involving culture of endometrial stromal cells (ESCs). After obtaining endometrial samples, ESCs were harvested and cultured for 13 days. The concentrations in culture media and the protein expressions in ESCs of prolactin (PRL) and insulin-like growth factor binding protein-1 (IGFBP-1), two well known decidualization markers used in a large number of in vitro models, were analyzed by ELISA and Western blotting, respectively, and the cell numbers were also counted. The mRNA levels of PRL and IGFBP-1 were tested by quantitative real time polymerase chain reaction (RT-PCR). Since sex hormone induce proliferation and differentiation to decidua via binding to the sex hormone receptors (ERα, ERβ, PRA, and PRB), their expression was assessed in another 17 patients’ paraffin-embedded endometrial tissue specimens by immunohistochemistry and semi-quantified by H-score.ResultsIncreased cell numbers and reduced secretion of PRL and IGFBP-1 were detected by ELISA in the ESCs of CE patients after culture for 13 days compared with non-CE patients. The decreased protein expression of IGFBP-1 in ESCs of CE patients was detected by Western blotting. The decreased expression of PRL mRNA and IGFBP-1 mRNA were detected by RT-PCR. Increased expressions of ERα, ERβ, PRA, and PRB were observed in the stromal cells of CE patients in comparison to non-CE patients, whereas increased expressions of ERα and ERβ were detected in the glandular cells of CE.ConclusionOur data suggests that CE modifies decidualization of human ESC through untuning the function of sex steroid hormone receptor.Electronic supplementary materialThe online version of this article (doi:10.1186/s12958-017-0233-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

“…However, recent research has shown a higher prevalence of CE in infertile patients (range 2.8 to 46%) [4–8] and relationships with recurrent abortion and repeated implantation failure [4, 9, 10]. Furthermore, a new clinical study reported that CE decreases the success rate of in vitro fertilization (IVF) [11].…”

Section: Introductionmentioning

confidence: 99%

Chronic endometritis modifies decidualization in human endometrial stromal cells

Kimura

Zheng

et al. 2017

Reprod Biol Endocrinol

122

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“…It has been thought not to affect the reproductive status and ability of affected women [1]. However, recent studies have reported that chronic endometritis is associated with infertility and recurrent abortion; it has been identified in 12–46% of infertile patients, 30% of repeated implantation failures after in vitro fertilization-embryo transfer, 28% of unexplained infertility, and 12% of unexplained recurrent miscarriages [3]–[7]. In chronic endometritis, a number of immune cells including plasma cells is found in the endometrium.…”

Section: Introductionmentioning

confidence: 99%

The Association between Endometriosis and Chronic Endometritis

et al. 2014

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ObjectiveTo evaluate the association between endometriosis and chronic endometritis.MethodsEndometrial specimens were obtained from 71 patients, 34 with endometriosis (endometriosis group) and 37 without endometriosis (non-endometriosis group), who underwent hysterectomy, and the specimens were immunostained for the plasmacyte marker CD138. The rate of chronic endometritis was compared between the endometriosis group and the non-endometriosis group. Furthermore, the 71 patients were also divided into two groups, 28 with chronic endometritis (chronic endometritis group) and 43 without chronic endometritis (non-chronic endometritis group). Logistic regression analysis was performed with variables including age, body mass index (BMI), gravidity and parity, and diagnoses of leiomyoma, adenomyosis, and endometriosis on pathology to examine the independent effect of each variable on chronic endometritis. Patients suffering from cervical invasive carcinoma, endometrial carcinoma, and endometrial polyps or treated with gonadotropin-releasing hormone agonists, progestins, or oral contraceptives before surgery were excluded.ResultsChronic endometritis was identified in 52.94% of the endometriosis group and 27.02% of the non-endometriosis group (p<0.05). Logistic regression analysis revealed that endometriosis was associated with chronic endometritis.ConclusionsThis result suggests a strong association between endometriosis and chronic endometritis.

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“…, have also recommended screening the uterus by hysteroscopy before proceeding with IVF, to minimize implantation failures. [14]…”

Section: Discussionmentioning

confidence: 99%

Role of hysteroscopy prior to assisted reproductive techniques

Palshetkar

Pai

Pisat

2009

J Gynec Endosc Surg

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Background:There have been numerous advances in the area of assisted reproduction. Among the various reasons of implantation failure, intrauterine lesions play an important role.Objective:The aim of the present study is to evaluate the role of hysteroscopy prior to any assisted reproductive technique.Materials and Methods:It is a retrospective study of 292 women who attended our infertility clinic over a period of 18 months, who had a variable number of failed IVF cycles previously.Results:Out of the 292 women studied, in 74 women, that is 25%, intrauterine pathology was detected, which when rectified by hysteroscopy, gave a considerable increase in pregnancy rate.Conclusion:According to this study it can be concluded that evaluating the uterine cavity is an important step before any assisted reproductive procedures.

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Hystéroscopie systématique avant fécondation in vitro

Cited by 54 publications

References 10 publications

Chronic endometritis modifies decidualization in human endometrial stromal cells

Chronic endometritis modifies decidualization in human endometrial stromal cells

The Association between Endometriosis and Chronic Endometritis

Role of hysteroscopy prior to assisted reproductive techniques

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