Objective. To compare the frequency of lifetime psychiatric disorders among 3 groups of subjects: patients with fibromyalgia syndrome (FMS) from a tertiary care setting, community residents with FMS who had not sought medical care for their FMS symptoms (' 'FMS nonpatients' '), and healthy controls. Fibromyalgia syndrome (FMS) is a relatively common, chronic musculoskeletal pain disorder of unknown cause that affects -15% of rheumatology clinic patients (1). The etiopathogenesis of FMS is not understood, but peripheral factors (e.g., muscle tissue abnormalities) and central factors (e.g., ,neurohormonal changes, abnormal regional cerebral blood flow) have been associated with symptom onset ( 2 4 ) .Psychiatric disorders and psychological distress represent one set of central factors that may influence the behavior of patients with FMS. Some investigators have suggested that psychiatric illness also may play a role in the development of FMS. For example, Hudson and colleagues recently utilized a structured interview, the Diagnostic Interview Schedule, to assess lifetime rates of psychiatric diagnoses in patients with FMS or rheumatoid arthritis (RA) in a tertiary care rheumatology clinic. Higher rates both of major mood disorders (64% versus 22%) and of panic disorder or agoraphobia (33% versus 11%) were found in FMS versus RA patients. Moreover, for the majority of diagnoses, initial symptoms predated the onset of pain among the FMS patients (5,6). Although these observations were based on the interview responses of patients who may not have been representative of community residents with FMS, it was concluded that FMS may share a common pathophysiology with depressive and anxiety disorders.Wolfe and colleagues recently examined psychological distress in FMS clinic patients and community residents with FMS (7). They found high levels of psychological distress in both groups and therefore suggested that psychological distress is intrinsically related to the FMS syndrome. However, the cornmu-