Hysteria and Drug‐induced Dystonia

Angus, J. W. S.; Simpson, George M.

doi:10.1111/j.1600-0447.1970.tb02071.x

Cited by 14 publications

(1 citation statement)

References 14 publications

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“…Genelikle bafl ve boyun kaslar›n› tutar. Tortikollis, fasial grimaslar ve okulojirik krizler fleklinde olabilir (1,2). Antipsikotik ilaçlar D2-dopamin reseptörü arac›l›¤› ile distoniye neden olurlar.…”

Section: Giriflunclassified

Antipsikotik Kullanımına Bağlı Bilateral Temporomandibuler Eklem Dislokasyonu

Annagür¹,

Tamam²

2011

npa

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Acute dystonia is the most dramatic extrapyramidal side effect and occurs as the first adverse effect of neuroleptics during the antipsychotic drug therapy. Dystonias are involuntary, continuous or spasmodic contractions of muscles. They may cause abnormal twisting, rhythmic movements and abnormal postures. They generally affect the head and neck muscles. Acute dystonia is a situation of psychiatric emergency and may affect vital functions of the patients. Acute dystonia quickly responses to treatment, however, some cases may give late response to treatment and unexpected complications may occur. One of these complications is dislocation of the temporomandibular joint. In this report, we present a case, which developed acute dystonia after a depot injection of intramuscular zuclopenthixol and was diagnosed with bilateral temporomandibular joint dislocation during further investigations, which were conducted as the case did not improve despite the treatment. In this case, the adverse effects and complications were more dramatic and prolonged due to the unwarranted administration of antipyschotic drug. Development of temporomandibular joint dislocation may be misleading in that dystonia is unresponsive to treatment. Clinicians should be careful about the side effects of neuroleptics and the complications caused by these side effects. (Archives of Neuropsychiatry 2010; 47: 351-3)

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Section: Giriflunclassified

Antipsikotik Kullanımına Bağlı Bilateral Temporomandibuler Eklem Dislokasyonu

Annagür¹,

Tamam²

2011

npa

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Withdrawal of Antiparkinson Drugs

Orlov¹

1971

Arch Gen Psychiatry

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The effects of the atypical antipsychotic amperozide on vacuous jaw movements in rats: a novel dose response profile

et al. 1998

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Classic neuroleptic drugs produce a syndrome of vacuous jaw movements in rats, and this syndrome has been offered as an animal model of early onset extrapyramidal side effects. The atypical antipsychotics do not produce elevations in vacuous jaw movements, or do so only at very high doses. The purpose of the present study was to determine the impact of the putative antipsychotic, amperozide, on vacuous jaw movements in rats. Groups of rats received daily injections of haloperidol (0.2, 0.4, or 0.8 mg/kg), clozapine (2.0, 4.0, 8.0 mg/kg), amperozide (2.0, 4.0, 8.0 mg/kg) or vehicle for 4 weeks. Once per week, rats were observed for the presence of vacuous jaw movements. Haloperidol increased vacuous jaw movements with increasing doses. Clozapine only produced elevations in vacuous jaw movements at the highest dose. In contrast, increasing doses of amperozide resulted in decreasing vacuous jaw movements for this portion of the dose-response curve. This is the first report of the effect of amperozide on vacuous jaw movements and results are discussed in terms of a potentially unique behavioral profile with respect to this behavior.

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Hysteria and Drug‐induced Dystonia

Cited by 14 publications

References 14 publications

Antipsikotik Kullanımına Bağlı Bilateral Temporomandibuler Eklem Dislokasyonu

Antipsikotik Kullanımına Bağlı Bilateral Temporomandibuler Eklem Dislokasyonu

Withdrawal of Antiparkinson Drugs

The effects of the atypical antipsychotic amperozide on vacuous jaw movements in rats: a novel dose response profile

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