Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

Arleth, Tobias; Olsen, Markus Harboe; Orre, Matias; Rasmussen, Rune; Bache, Søren; Eskesen, Vagn; Frikke‐Schmidt, Ruth; Møller, Kirsten

doi:10.1007/s00701-020-04310-z

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…As the patient's brain tissue and cranial nerves have been damaged, it is necessary to repair the damaged nerve cells, re-establish nerve function, and promote the patient's recovery. Conventional care is now the usual clinical choice to restore consciousness, but with less than satisfactory results [23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

High-Quality Nursing Combined with the Whole-Course Responsibility Nursing Intervention Reduces the Incidence of Complications in Severe Aneurysmal Subarachnoid Hemorrhage

Qian

Lin²,

Zhou

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study is to study the influence of whole-course responsibility nursing combined with high-quality nursing intervention on the level of life and complications of severe aneurysmal subarachnoid hemorrhage patients with postoperative coma. Methods. From December 2018 to December 2020, 90 severe aneurysmal subarachnoid hemorrhage patients with postoperative coma were selected and were divided into two groups, the experimental group and the control group, with 45 cases in each group. The control group adopted conventional nursing care, and the experimental group received whole-course responsibility nursing combined with high-quality nursing intervention. The nursing effect, degree of coma, coma recovery, and incidence of complications between all groups were compared. Results. Compared with the control group, the experimental group yielded more favorable achievement in terms of the nursing effect ( P < 0.05 ). Superior levels of the Glasgow Coma Scale (GCS) score, Coma Recovery Scale-Revised (CRS-R) score, GQOLI-74 score, and BI score of the experimental group were obtained and compared with the control group (all P < 0.05 ). The experimental group witnessed a lower complication rate, as compared to the other group ( P < 0.05 ). Conclusion. The whole-course responsibility nursing combined with high-quality nursing intervention is applied to severe aneurysmal subarachnoid hemorrhage patients with postoperative coma, which can substantially optimize the nursing efficiency, improve the degree of coma, help recover consciousness, ameliorate the mental state and the quality of life, and reduce the incidence of complications, which is worthy of clinical application.

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Section: Discussionmentioning

confidence: 99%

High-Quality Nursing Combined with the Whole-Course Responsibility Nursing Intervention Reduces the Incidence of Complications in Severe Aneurysmal Subarachnoid Hemorrhage

Qian

Lin²,

Zhou

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…In a recent retrospective analysis of 384 patients with acute subarachnoid haemorrhage, Arleth et al [69] investigated the frequency of serum zinc deficiency. They found reduced serum zinc levels in 67% (n = 257) of all patients within the first seven days after the event.…”

Section: Zinc Deficiency: Influence On Vessels Coagulation and Strokementioning

confidence: 99%

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

2020

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Zinc is an essential trace element for human health and plays a fundamental role in metabolic, immunological and many other biological processes. The effects of zinc are based on the intra- and extracellular regulatory function of the zinc ion (Zn2+) and its interactions with proteins. The regulation of cellular zinc homeostasis takes place via a complex network of metal transporters and buffering systems that react to changes in the availability of zinc in nutrition, chronic diseases, infections and many other processes. Zinc deficiency is associated with impairment of numerous metabolic processes, reduced resistance to infections due to impaired immune functions, changes in skin and its appendages and disorders of wound healing and haemostasis. While ischemic heart attacks (myocardial infarction) occur more frequently with meat-based normal diets, haemorrhagic strokes are more frequently observed with vegetarian/vegan diets. The causes are discussed as deficiencies of various micronutrients, such as vitamin B12, vitamin D, various amino acids and also zinc. In the present review, after a description of the functions of zinc and its resorption, a discussion of daily food intake will follow, with a special focus on the importance of food composition and preparation for the zinc balance. The close interrelationships between proteins, especially albumin and zinc will be discussed. Finally, the possible causes and consequences of a zinc deficiency on the blood vessels and blood coagulation are considered.

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“…Because of these potentially dangerous effects on organ function, correction of hypophosphataemia is generally recommended in patients with associated symptoms or with severe hypophosphataemia below 0.32 mmol/L 6,10 . Since both hypozincaemia and hypomagnesaemia have previously been linked to poor outcome in patients with aSAH, 11,12 we hypothesised that a similar association would exist for hypophosphataemia.…”

Section: Introductionmentioning

confidence: 97%

Hypophosphataemia is common in patients with aneurysmal subarachnoid haemorrhage

Erritzøe-Jervild

Wesierski

Романо

et al. 2021

Acta Anaesthesiol Scand

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Introduction Hypophosphataemia is common in critically ill patients, but neither its prevalence nor its association with outcome have been investigated specifically in patients with aneurysmal subarachnoid haemorrhage (aSAH). Methods Patients with aSAH and at least one phosphate measurement were included from two independent cohorts; an American cohort extracted from two open‐access databases (Medical Information Mart for Intensive Care‐III and eICU Collaborative Research Database v. 2.0) and a Danish cohort consisting of patients with aSAH admitted to Rigshospitalet, Denmark over a 4‐year period. In each cohort, we calculated the prevalence of mild (0.32–0.80 mmol/L) and severe (<0.32 mmol/L) hypophosphataemia and their association with in‐hospital mortality before and after propensity‐score matching. Results Hypophosphataemia occurred in 72.4% (95% CI: 68.1–76.3) of patients in the American cohort (n = 471) and 54.9% (50.0–59.7) in the Danish cohort (n = 419). However, it was not associated with mortality in neither full (American: Mild, Odds ratio (OR) 0.99 (0.91–1.07), Severe OR 1.20 (0.95–1.51); Danish: Mild, OR 1.01 (0.95–1.08), Severe OR 1.20 (0.95–1.51)) nor propensity‐score matched cohorts (American (n = 168): Mild, OR 1.06 (0.88–1.28), Severe OR 1.46 (0.96–2.12); Danish (n = 44): Mild, OR 1.16 (0.82–1.65), Severe OR 0.45 (0.13–1.55)). Conclusion In this retrospective study of patients with aSAH, hypophosphataemia was common.

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Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

Cited by 5 publications

References 38 publications

High-Quality Nursing Combined with the Whole-Course Responsibility Nursing Intervention Reduces the Incidence of Complications in Severe Aneurysmal Subarachnoid Hemorrhage

High-Quality Nursing Combined with the Whole-Course Responsibility Nursing Intervention Reduces the Incidence of Complications in Severe Aneurysmal Subarachnoid Hemorrhage

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

Hypophosphataemia is common in patients with aneurysmal subarachnoid haemorrhage

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