Hypoxis hemerocallidea—Not merely a cure for benign prostate hyperplasia

Drewes, Siegfried E.; Elliot, Emma; Khan, Fatima; Dhlamini, Jabu T.B.; Gcumisa, M.S.S.

doi:10.1016/j.jep.2008.05.027

Cited by 64 publications

(37 citation statements)

References 27 publications

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“…Many other crude extracts had been tested previously for their antioxidant activity, as reported briefly by Drewes et al (2008). It was found that Hypoxis hemerocallidea extract; another traditionally used plant of South Africa had an IC 50 value of 75 µg/mL when it was determined by TBA assay.…”

Section: Apoptosis Detection Analysis After 72h Incubationmentioning

confidence: 98%

In vitro chemo-preventative activity of Crotalaria agatiflora subspecies agatiflora Schweinf

Roux

Hussein

Lall

2011

Journal of Ethnopharmacology

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Ethnopharmacological relevance: Crotalaria species have been widely used in Chinese traditional medicine to treat several types of internal cancers. Crotalaria agatiflora is used as a medicinal plant in several African countries for the treatment of bacterial and viral infections as well as for cancer. Materials and methods:Water and ethanol extracts of the leaves of C. agatiflora were evaluated for cytotoxcity on four cancerous and one noncancerous cell lines, using XTT (Sodium 3' -[1-(phenyl amino-carbonyl)-3,4-tetrazolium]-bis-[4-methoxy-6-nitro) benzene sulfonic acid hydrate) colorimetric assay. Antioxidant activity was determined using DPPH (1,1-Diphenyl-2-picryl hydrazyl). Light microscopy (eosin and hematozylin staining) and flow cytometry (Annexin-V and propidium iodide) were used to evaluate the mechanism of action of the ethanol extract and one of the isolated compounds. Results Conclusions:The results indicated that C. agatiflora possesses potential chemopreventative and therapeutic properties. The exact mechanism of action should still be determined in future studies.It is hypothesised that the ethanolic extract as well as madurensine induces autophagy, which in prolonged circumstances may lead to autophagic cell death.

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Section: Apoptosis Detection Analysis After 72h Incubationmentioning

confidence: 98%

In vitro chemo-preventative activity of Crotalaria agatiflora subspecies agatiflora Schweinf

Roux

Hussein

Lall

2011

Journal of Ethnopharmacology

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“…In South Africa, the genus is distributed in �ve provinces, namely, KwaZulu-Natal, Eastern Cape, Mpumalanga, Limpopo, and Gauteng but is also found in Lesotho, Swaziland, Mozambique, and Zimbabwe [81][82][83]. Medicinally, the African potato has been used by different cultures for many ailments such as bad dreams, cardiac diseases, impotency, apprehension, barrenness, and intestinal parasites, and today it is even used for cancer, headaches, dizziness, as an immune booster, testicular cancer, prostate hypertrophy, burns, and ulcers [82].…”

Section: Hypoxis Hemerocallidea (Hypoxidaceae)mentioning

confidence: 99%

Commercially Important Medicinal Plants of South Africa: A Review

Street

Prinsloo

2012

Journal of Chemistry

138

114

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ere is a growing interest in natural plant-based remedies as a source for commercial products. Around 80% of the South African population use traditional medicines to meet their primary health care needs; however, only a few South African medicinal plants have been exploited to their full potential in terms of commercialization. e opportunity for bioprospecting of plant compounds for novel pharmaceuticals remains largely untapped. Certain renowned medicinal plants of international acclaim including buchu and rooibos are currently contributing to local enterprise; however, other exciting opportunities exist for commonly used plants which have not yet reached the international arena. is paper focuses on the key research and development contributions of 10 commercially important medicinal plants of South Africa. �raditional uses, scienti�c validation, commercialisation developments, as well as both potential opportunities and setbacks are discussed.

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“…In general, all the plants in this study displayed both antiinfective and toxic properties ( Table 1) whilst reports from phytochemical studies reflect flavonoids and condensed tannins largely responsible for the observed antiviral and anticancer activities [25]- [28] [38] [39]. Isolated fractions and derivatives can have greater toxicity and/or activity than the crude extracts, the case of artemisinin from Artemisia annua in the treatment of malaria [39] and the isolated phytoconstituents from Kigelia and Hypoxis species [24]- [27].…”

Section: Cytotoxicity and Antiviral Activitymentioning

confidence: 82%