Hypoxic regions exist in human prostate carcinoma

Movsas, Benjamin; Chapman, J. D.; Horwitz, Eric M.; Pinover, Wayne H.; Greenberg, Richard E.; Hanlon, Alexandra L.; Iyer, Renuka; Hanks, Gerald E.

doi:10.1016/s0090-4295(98)00500-7

Cited by 156 publications

(91 citation statements)

References 20 publications

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“…40 Hypoxia is present in localised prostate cancer: by measuring the partial pressure of oxygen using Eppendorf pO 2 microelectrodes, regions of prostate cancer have been shown to be hypoxic when compared with areas of normal prostate or adjacent muscle. 41,42 Oxygen measurements from the pathologically involved portion of the prostate were significantly lower than those from normal muscle. Similarly, higher pO 2 readings were obtained from pathologically normal prostates (in patients with bladder cancer) compared with the prostates of patients with prostate cancer.…”

Section: Angiogenesismentioning

confidence: 76%

“…It is known that hypoxic cells are radioresistant, requiring 2-3 times more radiation to kill them, 65 that hypoxic regions exist in human prostate carcinoma and that tumour hypoxia is an independent prognostic indicator of poor outcome in prostate and other tumours. 41,66,67 Radioresistance may therefore arise because of the hypoxic tumour microenvironment. 68 There is evidence to suggest that, paradoxically, antiangiogenic therapy may actually increase delivery of oxygen to the tumour by reducing vascular permeability, which allows for increased oxygen delivery by more normal vasculature.…”

Section: Angiogenesismentioning

confidence: 99%

See 1 more Smart Citation

Effects of androgen suppression and radiation on prostate cancer suggest a role for angiogenesis blockade

Woodward

Wachsberger

Burd

et al. 2005

Prostate Cancer Prostatic Dis

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Section: Angiogenesismentioning

confidence: 76%

Section: Angiogenesismentioning

confidence: 99%

Effects of androgen suppression and radiation on prostate cancer suggest a role for angiogenesis blockade

Woodward

Wachsberger

Burd

et al. 2005

Prostate Cancer Prostatic Dis

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“…British Journal of Cancer (2009) The relationship of radiosensitivity to varying oxygenation and the detrimental effects of hypoxia in human tumours was first shown over 50 years ago (Gray et al, 1953;Tomlinson and Gray, 1955). Since then, it has been established that hypoxia is an important factor in radiotherapy treatment failure and has been associated in clinical studies with poor local tumour control and relapse in many cancer sites (Nordsmark et al, 1996;Fyles et al, 1998;Brizel et al, 1999;Movsas et al, 2002;Hoskin et al, 2003).Eppendorf microelectrode measurements have been used to invasively characterise the range and heterogeneity of oxygen partial pressures in the prostate and show that hypoxic regions exist in human prostate carcinoma (Movsas et al, 1999;Parker et al, 2004). The outcome of radical radiotherapy for prostate cancer is influenced by the presence of hypoxia.…”

mentioning

confidence: 99%

“…Eppendorf microelectrode measurements have been used to invasively characterise the range and heterogeneity of oxygen partial pressures in the prostate and show that hypoxic regions exist in human prostate carcinoma (Movsas et al, 1999;Parker et al, 2004). The outcome of radical radiotherapy for prostate cancer is influenced by the presence of hypoxia.…”

mentioning

confidence: 99%

Carbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans

Alonzi

Padhani

Maxwell³

et al. 2009

Br J Cancer

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Hypoxia has been associated with poor local tumour control and relapse in many cancer sites, including carcinoma of the prostate. This translational study tests whether breathing carbogen gas improves the oxygenation of human prostate carcinoma xenografts in mice and in human patients with prostate cancer. A total of 23 DU145 tumour-bearing mice, 17 PC3 tumour-bearing mice and 17 human patients with prostate cancer were investigated. Intrinsic susceptibility-weighted MRI was performed before and during a period of carbogen gas breathing. Quantitative R 2 * pixel maps were produced for each tumour and at each time point and changes in R 2 * induced by carbogen were determined. There was a mean reduction in R 2 * of 6.4% (P ¼ 0.003) for DU145 xenografts and 5.8% (P ¼ 0.007) for PC3 xenografts. In all, 14 human subjects were evaluable; 64% had reductions in tumour R 2 * during carbogen inhalation with a mean reduction of 21.6% (P ¼ 0.0005). Decreases in prostate tumour R 2 * in both animal models and human patients as a result of carbogen inhalation suggests the presence of significant hypoxia. The finding that carbogen gas breathing improves prostate tumour oxygenation provides a rationale for testing the radiosensitising effects of combining carbogen gas breathing with radiotherapy in prostate cancer patients. British Journal of Cancer (2009) The relationship of radiosensitivity to varying oxygenation and the detrimental effects of hypoxia in human tumours was first shown over 50 years ago (Gray et al, 1953;Tomlinson and Gray, 1955). Since then, it has been established that hypoxia is an important factor in radiotherapy treatment failure and has been associated in clinical studies with poor local tumour control and relapse in many cancer sites (Nordsmark et al, 1996;Fyles et al, 1998;Brizel et al, 1999;Movsas et al, 2002;Hoskin et al, 2003).Eppendorf microelectrode measurements have been used to invasively characterise the range and heterogeneity of oxygen partial pressures in the prostate and show that hypoxic regions exist in human prostate carcinoma (Movsas et al, 1999;Parker et al, 2004). The outcome of radical radiotherapy for prostate cancer is influenced by the presence of hypoxia. A study that prospectively analysed 57 patients with localised disease showed that hypoxic tumours had a significantly worse biochemical relapse-free survival at 2 years (31 vs 92%, Po0.0001; Movsas et al, 2002). Oxygenation status is therefore an additional prognostic factor beyond the classic prognostic factors (age, clinical stage, Gleason score and prostate-specific antigen) that predicts radiation treatment failure in prostate cancer. A modelling study based on these clinical data predicts an oxygen enhancement ratio for prostate cancer of 1.4 (95% confidence interval of 1.2-1.8) that is consistent with the in vitro OER measurements of human tumour cell lines under chronic hypoxia conditions (Wang et al, 2006). These data taken together suggest that hypoxia is likely to be a valid therapeutic target in prostate cancer.The ...

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“…The existence of hypoxic areas in prostate cancer has been proved to date by many researchers [38,[40][41][42]. With immunohistochemistry tests, which use hypoxic cell markers and direct oxygen electrode measurements, clinically relevant levels of hypoxia are detected in 30-90% of prostate cancer cases.…”

Section: Hypoxia In Prostate Cancermentioning

confidence: 99%

Hypoxia in prostate cancer

Danielska

Łuniewska-Bury²,

Kuncman³

et al. 2017

Nowotwory. Journal of Oncology

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Most human solid tumours contain areas which are less oxygenated than normal tissues. Hypoxia increases resistance to radiotherapy, surgery and chemotherapy, and directly alters the function of tumour cells, stimulating them to de-differentiate and to release angiogenic factors with a view to increasing the blood and oxygen supply. Tumour hypoxia promotes malignant progression and metastasis formation. HIF-1 is a heterodimeric transcription factor composed of regulated HIF-1a and constitutively expressed HIF-1b. Tumour-associated activation of HIF-1a seems to be primarily, however the result of adaptation to oxygen shortage. The presence of the HIF-1a subunit overexpression has been confirmed in many tumours, in prostate cancer, among others; the role it plays in its progression is yet to be explained. Numerous studies strongly emphasize the importance of evaluating the status of the HIF-1a transcription factor in predicting the clinical and biochemical recurrence of prostate cancer and its resistance to castration. NOWOTWORY J Oncol 2017; 67, 2: 132-136

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Hypoxic regions exist in human prostate carcinoma

Cited by 156 publications

References 20 publications

Effects of androgen suppression and radiation on prostate cancer suggest a role for angiogenesis blockade

Effects of androgen suppression and radiation on prostate cancer suggest a role for angiogenesis blockade

Carbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans

Hypoxia in prostate cancer

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