Abstract:Hypoxic preconditioning (HPC) as an endogenous mechanism
can resist
hypoxia/ischemia injury and exhibit protective effects on neurological
function including learning and memory. Although underlying molecular
mechanisms remain unclear, HPC probably regulates the expression of
protective molecules by modulating DNA methylation. Brain-derived
neurotrophic factor (BDNF) activates its signaling upon binding to
the tropomyosin-related kinase B (TrkB) receptor, which is involved
in neuronal growth, differentiation, … Show more
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