Hypoxic hypoxia as a haemostatic system-activating factor

Abstract

Aimed at investigating influence of hypoxic hypoxia of different duration on haemostatic system state, the assessment of coagulogram in 152 Vistar rats 1 and 3 hours after single «lifting» to the height of 5500 m over sea level in pressure chamber and after daily 3 hours during 7 and 30 days. Activating influence of single hypoxic xypoxia was on hemostasis was revealed. While in-creasing duration of single impact , activation hemostatic system increased and anticoagulant and fibrinolytic properties of blood plasma decreased. According to the coagulogram data, prethrombotic changes developed in the form of coagulation activation, thrombocytes intake, decreased anti-thrombin III level and fibrinolytic activity on the 7-th day of hypoxia. On the 30-th day, de-creased hemostatic activity with increasing anticoagulant plasma blood reserve and restorating fibrinolytic activity.