2011
DOI: 10.1182/blood.v118.21.3417.3417
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Hypoxic Hematopoietic Stem and Progenitor Cells Reside in Structurally Diverse Perivascular Niches in the Bone Marrow,

Abstract: 3417 The identification of specific microenvironments, in which Hematopoietic Stem and Progenitor Cells (HSPCs), reside within the BM is a major challenge in stem cell biology. Yet the extreme rarity of HSCs, their dynamic nature, and the lack of unique specific markers to identify them, have precluded an accurate definition of HSC niches to date. Using Laser Scanning Cytometry, a powerful emerging quantitative imaging technology that enables analysis of whole femoral sections at the single cell… Show more

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“…Indeed, circulating HSC, which reside in a normoxic environment, maintain expression of HIF1alpha (75). Recently, it has been shown oxygen partial pressure status of HSC and committed HSC progenitors is phenotype-dependent rather than localization-dependent (76). This has been backed by direct measurement of the partial oxygen pressure within mouse bone marrow which demonstrated that the HSC reside along arterial-like vessels, but that the oxygen in these vessels depletes rapidly upon entering the bone marrow cavity (77).…”
Section: Hypoxia and Stem Cellsmentioning
confidence: 99%
“…Indeed, circulating HSC, which reside in a normoxic environment, maintain expression of HIF1alpha (75). Recently, it has been shown oxygen partial pressure status of HSC and committed HSC progenitors is phenotype-dependent rather than localization-dependent (76). This has been backed by direct measurement of the partial oxygen pressure within mouse bone marrow which demonstrated that the HSC reside along arterial-like vessels, but that the oxygen in these vessels depletes rapidly upon entering the bone marrow cavity (77).…”
Section: Hypoxia and Stem Cellsmentioning
confidence: 99%