Hypoxia treatment of Parkinson’s disease may disrupt the circadian system

Reply to: Hypoxia treatment of Parkinson’s disease may disrupt the circadian system

“…OSA is a disorder characterized by recurrent episodes of partial or complete airway obstruction, resulting in intermittent hypoxia during nocturnal sleep (thus typically imposed for 7-9 h) where oxygen saturations below 80% are common [17]. As suggested by Coste & Touitou [6], an hours-long experimental protocol may adversely affect the circadian rhythm, either by disturbed sleep or due to persistent sympathetic activation [18,19]. Although a causal relation between sleep apnea and PD has not been established in humans, associations between OSA incidence and PD risk have been reported [20].…”

“…These data will provide insight into the influence of hypoxia on the acute and subacute sympathetic system activation and stress response. However, despite these measures, and in light of Coste & Touitou's correspondence [6], we think it is appropriate to include an exploratory outcome for sleep quality and circadian rhythm to any follow-up studies in PD hypoxia trials. Further safety and response-related results from this phase 1 study will be addressed in separate reports.…”

“…In Coste & Touitou's recent correspondence [5] to our protocol [6], they highlighted the potential for circadian rhythm disturbances induced by hypoxia in PD. This interesting insight is based on their two different studies, in which a phase shift in circadian rhythm (as measured by cortisol and melatonin) was observed after eighthours-long 'chronic' exposure to hypoxia [7,8].…”

“…This interesting insight is based on their two different studies, in which a phase shift in circadian rhythm (as measured by cortisol and melatonin) was observed after eighthours-long 'chronic' exposure to hypoxia [7,8]. Coste & Touitou [6] carefully considered that hypoxia-based interventions could therefore induce changes in circadian rhythm, and this may in turn affect the outcome of these interventions. Here, we discuss important differences between chronic hypoxia, which resembles hypoxia as a disease model for sleep apnea, and hypoxic conditioning.…”

Correction to: Hypoxia treatment of Parkinson’s disease may disrupt the circadian system

“…Following publication of the original article [ 1 ], the authors reported an error found in the Introduction and Methodological considerations sections. The author “Janssen Daalen et al” was erroneously referred to as ‘Daalen et al’.…”