Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy

Liu, Xue; Wu, Zhenfeng; Guo, Caixia; Guo, Huimin; Su, Yanguo; Chen, Qiang; Sun, Changgang; Liu, Qingming; Chen, Daquan; Mu, Hongjie

doi:10.1080/10717544.2021.2021324

Cited by 58 publications

(30 citation statements)

References 40 publications

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“…This provided us with the data basis for the subsequent combination of insoluble drugs and nano–liposomes. The results of FTIR ( Figure 3 A) were consistent with previous studies [ 35 , 36 ], DP will not affect the structure of liposomes after adding liposomes. TEM results ( Figure 3 B) also confirmed this point.…”

Section: Discussionsupporting

confidence: 91%

Nano–Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti–Tumor Effects

Song

Liu

Guo

et al. 2022

IJMS

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(1) Background: Curcumin (CUR) and tetrandrine (TET) are natural compounds with various bioactivities, but have problems with low solubility, stability, and absorption rate, resulting in low bioavailability, and limited applications in food, medicine, and other fields. It is very important to improve the solubility while maintaining the high activity of drugs. Liposomes are micro–vesicles synthesized from cholesterol and lecithin. With high biocompatibility and biodegradability, liposomes can significantly improve drug solubility, efficacy, and bioavailability. (2) Methods: In this work, CUR and TET were encapsulated with nano–liposomes and g DSPE–MPEG 2000 (DP)was added as a stabilizer to achieve better physicochemical properties, biosafety, and anti–tumor effects. (3) Results: The nano–liposome (CT–DP–Lip) showed stable particle size (under 100 nm) under different conditions, high solubility, drug encapsulation efficiency (EE), loading capacity (LC), release rate in vitro, and stability. In addition, in vivo studies demonstrated CT–DP–Lip had no significant toxicity on zebrafish. Tumor cytotoxicity test showed that CT–DP–Lip had a strong inhibitory effect on a variety of cancer cells. (4) Conclusions: This work showed that nano–liposomes can significantly improve the physical and chemical properties of CUR and TET and make them safer and more efficient.

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Section: Discussionsupporting

confidence: 91%

Nano–Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti–Tumor Effects

Song

Liu

Guo

et al. 2022

IJMS

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“…3.C.a). [42] The above results indicate that we have successfully synthesized the carrier material SCCF, CCF.…”

Section: H-nmr and Ft-irmentioning

confidence: 58%

Dual-targeting micelles with ROS-sensitive H2S donor based on Sialic acid and Chondroitin sulfate for atherosclerosis

Chen

Guo

et al. 2022

Preprint

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Background: Currently, very limited therapeutic approaches are available for the drug treatment of atherosclerosis(AS). H2S-donor is becoming a common trend in much life-threatening research. Several studies have documented that H2S-lyase is predominantly present in endothelial cells. Sialic acid, natural carbohydrate, binds specifically to the E-selectin receptor of endothelial cells. Meanwhile, Recent studies related to Chondroitin sulfate have excellent target binding ability with CD44 receptor. We conjecture that the dual targeting of chondroitin sulfate and Sialic acid not only enhances the accumulation of the drug in the lesion but also cleaves the H2S donor, thus one stone two birds. Methods: Given these findings, we synthesized two kinds of nanoparticles, Carrier I (SCCF) and Carrier II (SCTM), for atherosclerosis to validate our guesses. Initially, S-allyl-L-cysteine and 4-methoxyphenylthiourea were used as H2S donors for SCCF and SCTM, respectively. After the introduction of ROS-sensitive groups. Then, chondroitin sulfate as the modified matrix and Sialic acid as the targeting group, micelles were prepared to load rapamycin(RAP). Results: In the in vitro assay, micelles were significantly different under H2O2 (1 mM) conditions. In the targeting test, the dual-target effect was superior to the other subgroups. treatment with SCCF@RAP and SCTM@RAP effect in AS is remarkable as confirmed via Oil Red O staining. Conclusions: Thus, we conclude that the effect of dual targeting nanomicelles with ROS-sensitive H2S donor will have a better role in atherosclerosis.

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“…In hypoxic environments, AZO compounds can be effectively reduced by NAD(P)H quinone dehydrogenase 1 (NQO1) and azoreductase into two separate aniline groups, rendering them suitable for preparing hypoxic-responsive nanoplatforms [ 286 – 288 ]. Moreover, matching the hypoxia-responsive features and the broad absorption wavelength of the AZO groups with the therapeutic bio-optical window can lead to more efficient stimulus responses.…”

Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy

Cited by 58 publications

References 40 publications

Nano–Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti–Tumor Effects

Nano–Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti–Tumor Effects

Dual-targeting micelles with ROS-sensitive H2S donor based on Sialic acid and Chondroitin sulfate for atherosclerosis

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

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