Hypoxia Response Element-Directed Expression of aFGF in Neural Stem Cells Promotes the Recovery of Spinal Cord Injury and Attenuates SCI-Induced Apoptosis

Ying, Yibo; Zhang, Yifan; Tu, Yurong; Chen, Min; Huang, Zhiyang; Ying, Weiyang; Wu, Qiuji; Ye, Jiahui; Xiang, Ziyue; Wang, Xiangyang; Wang, Zhouguang; Zhu, Sipin

doi:10.3389/fcell.2021.693694

Cited by 4 publications

(1 citation statement)

References 60 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the toxic microenvironment of the injury is unfavorable for survival of transplanted cells [ 18 ]. Previous studies reported that endogenous NSCs were activated after SCI in the central canal of the spinal cord, whereby they took part in the regeneration of neural function [ 19 , 20 ]. Therefore, promoting the proliferation and differentiation of NSCs can be an effective strategy for treatment of nerve injuries [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats

Liu

Zhou

Wang

et al. 2022

J Neuroinflammation

View full text Add to dashboard Cite

Background Spinal cord injury (SCI) causes devastating neurological damage, including secondary injuries dominated by neuroinflammation. The role of Apelin, an endogenous ligand that binds the G protein-coupled receptor angiotensin-like receptor 1, in SCI remains unclear. Thus, our aim was to investigate the effects of Apelin in inflammatory responses and activation of endogenous neural stem cells (NSCs) after SCI. Methods Apelin expression was detected in normal and injured rats, and roles of Apelin in primary NSCs were examined. In addition, we used induced pluripotent stem cells (iPSCs) as a carrier to prolong the effective duration of Apelin and evaluate its effects in a rat model of SCI. Results Co-immunofluorescence staining suggested that Apelin was expressed in both astrocytes, neurons and microglia. Following SCI, Apelin expression decreased from 1 to 14 d and re-upregulated at 28 d. In vitro, Apelin promoted NSCs proliferation and differentiation into neurons. In vivo, lentiviral-transfected iPSCs were used as a carrier to prolong the effective duration of Apelin. Transplantation of transfected iPSCs in situ immediately after SCI reduced polarization of M1 microglia and A1 astrocytes, facilitated recovery of motor function, and promoted the proliferation and differentiation of endogenous NSCs in rats. Conclusion Apelin alleviated neuroinflammation and promoted the proliferation and differentiation of endogenous NSCs after SCI, suggesting that it might be a promising target for treatment of SCI.

show abstract

Section: Introductionmentioning

confidence: 99%

Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats

Liu

Zhou

Wang

et al. 2022

J Neuroinflammation

View full text Add to dashboard Cite

show abstract

Progression in translational research on spinal cord injury based on microenvironment imbalance

2022

View full text Add to dashboard Cite

Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many years. Significant progress has been made in research on the pathological mechanism of spinal cord injury. In particular, with the development of gene regulation, cell sequencing, and cell tracing technologies, in-depth explorations of the SCI microenvironment have become more feasible. However, translational studies related to repair of the injured spinal cord have not yielded significant results. This review summarizes the latest research progress on two aspects of SCI pathology: intraneuronal microenvironment imbalance and regenerative microenvironment imbalance. We also review repair strategies for the injured spinal cord based on microenvironment imbalance, including medications, cell transplantation, exosomes, tissue engineering, cell reprogramming, and rehabilitation. The current state of translational research on SCI and future directions are also discussed. The development of a combined, precise, and multitemporal strategy for repairing the injured spinal cord is a potential future direction.

show abstract

Application of Traditional Graphic Elements Based on Fiber Bragg Grating Tactile Sensor Technology

2021

Journal of Sensors

View full text Add to dashboard Cite

In today’s era, sensing technology has been very developed in the fields of machinery, medicine, safety monitoring, and so on. In order to be applicable to more fields, new sensing technologies are also evolving. Tactile and sensory states are two important indicators of human induction to external things. Based on the contact force information between fiber Bragg grating tactile sensor and human body, this paper uses a new fiber Bragg grating tactile sensing system to study the artistic elements of ink painting in modern graphic design. Subsequently, the structure and specific performances of the sensor experimental data are analyzed. With its small volume, low cost, high sensitivity, and good compatibility with the observed body, the new fiber Bragg grating tactile sensor will not be affected by external electromagnetic interference, various noise signals, complex integration, and other problems. According to the data observed by ink painters in this paper, the new tactile sensing technology of fiber Bragg grating can well control the external interference factors. In general, the technology is of great social and practical value.

show abstract

Hypoxia Response Element-Directed Expression of aFGF in Neural Stem Cells Promotes the Recovery of Spinal Cord Injury and Attenuates SCI-Induced Apoptosis

Cited by 4 publications

References 60 publications

Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats

Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats

Progression in translational research on spinal cord injury based on microenvironment imbalance

Application of Traditional Graphic Elements Based on Fiber Bragg Grating Tactile Sensor Technology

Contact Info

Product

Resources

About