Hypoxia represses FOXF1 in lung endothelial cells through HIF-1α
Anusha Acharya,
Fenghua Bian,
Jose Gomez-Arroyo
et al.
Abstract:Introduction: Forkhead Box F1 (FOXF1) transcription factor plays a critical role in lung angiogenesis during embryonic development and lung repair after injury. FOXF1 expression is decreased in endothelial cells after lung injury; however, molecular mechanisms responsible for the FOXF1 transcript changes in injured lung endothelium remain unknown.Methods: We used immunostaining of injured mouse lung tissues, FACS-sorted lung endothelial cells from hypoxia-treated mice, and data from patients diagnosed with hyp… Show more
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