Hypoxia promotes white adipose tissues browning in rats under simulated environment at altitude of 5000 m

Song, Qiaoyue; Liu, Shiying; Wang, Jianan; Chai, Jiamin; Wen, Junhai; Cai, X.

doi:10.1016/j.bbrc.2023.05.015

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…It has been well-established that cold-exposure can induce BAT activation and AT browning in rats and humans [22,[41][42][44][45], which is consistent with the anticipated findings regarding the coldwater (15 o C) protocol. Moreover, hypoxic exercises have also been shown to induce BAT activation and AT in rats [29][30][31], particularly in the inguinal area [28,66], which is consistent with the anticipated findings for the hypoxia protocol, as proof of principle. The anticipated result for the hypoxic protocol is also consistent with the hypothesis by Mu et al, which highlighted the relationship of hypoxic exercise with better AT browning capabilities due to its ability to upregulate irisin and leptin levels [28].…”

Section: Discussionsupporting

confidence: 82%

“…Moreover, there is a lack of evidence regarding hypoxic exercise induced AT browning in human participants. However, studies have reported weight loss effects of hypoxic exercise, as well as its inducing WAT browning capabilities in rats, particularly with the upregulation of Irisin and Leptin levels, adipokines associated with AT browning by promoting adipose tissue transdifferentiation into beige adipose tissue as well as direct activation of WAT lipolysis and fatty acid oxidation [29][30][31][32][33]. Moreover, studies exploring the effects of hypoxic physical activity (PA) were usually replicated in a hypobaric environment using chambers or conducting studies in mid-mountain areas, which poses risks and limitations like organ structural changes, that can lead to collapse and fainting, as well as economic and technical difficulties [34].…”

Section: Exercise-induced Browningmentioning

confidence: 99%

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Assessing the Induced Adipose Tissue Browning Effects of Hypoxic Swimming and Cold-Water Exposure in Healthy Human Participants Using Contrast-Enhanced Ultrasound (CEUS)

Sales

2024

URNCST Journal

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Introduction:The prevalence of obesity in Canada has increased in recent years. Due to this, studies have been conducted on brown adipose tissue (BAT) as it consumes energy to regulate thermal homeostasis rather than storing it as fat. Particularly, studies have shown that exercise regimens combined with a cold-temperature setting elicit the most "browning" of white adipose tissue (WAT). Hypoxic exercise has been seen to prevent obesity and some metabolic disorders, but the browning of WAT via hypoxic exercise has yet to be studied. Thus, this study aims to determine the independent and synergistic effects of cold-water exposure and hypoxic exercise BAT activation and adipose tissue browning in healthy adult males. Methods: Moderately active healthy adult males will be randomized in three experimental groups (i.e., Cold-water exposure group (CG), Hypoxic exercise group (HG), and combined cold-water and hypoxic exercise group (HC)) and one control group. Familiarization sessions will be done prior to the three testing sessions. Cold conditions will be induced via exercise in 15 o C water. Hypoxic conditions will be induced via the endogenous-hypoxic breathing technique. Contrast-Enhanced Ultrasound (CEUS) scans of regions of interest (i.e., supraclavicular, axilla, anterior abdominal wall, and the inguinal fossa) will be obtained before and after familiarization and testing sessions and will be further utilized for analysis. Results: It is anticipated that all experimental groups will demonstrate BAT activation and adipose tissue browning as reflected by the Acoustic Intensity (AI) curve and color-flow doppler intensity. Particularly, more pronounced in the supraclavicular region for CG, inguinal fossa for HG, and both for HC. Discussion: This research protocol anticipates evidence that suggests independent cases of BAT activation and adipose tissue browning, reflected in the CG and HG. This protocol also anticipates synergistic effects of cold water and hypoxic exercise in inducing BAT activation and adipose tissue browning, reflected by HC. Conclusion: Thus, hypoxia and cold-water interventions may have potential clinical use for managing the rising cases of obesity. Future implications may include public health initiatives that inform the population on ways to mitigate the effects of obesity and provide a potential therapeutic avenue to treat the disease.

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Section: Discussionsupporting

confidence: 82%

Section: Exercise-induced Browningmentioning

confidence: 99%

Assessing the Induced Adipose Tissue Browning Effects of Hypoxic Swimming and Cold-Water Exposure in Healthy Human Participants Using Contrast-Enhanced Ultrasound (CEUS)

Sales

2024

URNCST Journal

View full text Add to dashboard Cite

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Exploring the Impact of Resistance Training at Moderate Altitude on Metabolic Cytokines in Humans: Implications for Adipose Tissue Dynamics

Pérez-Regalado,

Leon,

Padial

et al. 2024

IJMS

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Hypobaric hypoxia (HH) limits oxygen supply to tissues and increases metabolic demands, especially during exercise. We studied the influence of HH exposure on the subcutaneous adipose tissue (SAT) thickness and circulating metabolic-related cytokines levels after a resistance training (RT) program. Twenty trained men participated in a traditional hypertrophy RT for 8 weeks (three sessions/week) under intermittent terrestrial HH (2320 m) or normoxia (N, 690 m) conditions. Before, at week 6, and after the RT, SAT, and vastus lateralis (VL) muscle thickness were measured by ultrasound. Blood samples were taken to analyse serum cytokines (IL-6, IL-15, irisin, and myostatin) by multiplex immunoassay. Our findings revealed a moderate reduction in IL-6 and irisin in HH following the RT (ES < −0.64; p < 0.05). Additionally, RT in HH promoted serum IL-15 release (ES = 0.890; p = 0.062), which exhibited a trivial inverse association with the reductions observed on SAT (−17.69%; p < 0.001) compared with N. RT in HH explained ~50% of SAT variance (p < 0.001). These results highlight the benefit of stressor factors linked to RT in HH on SAT through the modulation of serum metabolic cytokine profiles, suggesting a potential effect on overall body composition.

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Hypoxia promotes white adipose tissues browning in rats under simulated environment at altitude of 5000 m

Cited by 2 publications

References 27 publications

Assessing the Induced Adipose Tissue Browning Effects of Hypoxic Swimming and Cold-Water Exposure in Healthy Human Participants Using Contrast-Enhanced Ultrasound (CEUS)

Assessing the Induced Adipose Tissue Browning Effects of Hypoxic Swimming and Cold-Water Exposure in Healthy Human Participants Using Contrast-Enhanced Ultrasound (CEUS)

Exploring the Impact of Resistance Training at Moderate Altitude on Metabolic Cytokines in Humans: Implications for Adipose Tissue Dynamics

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