Hypoxia-inducible factor signaling in vascular calcification in chronic kidney disease patients

Çöpür, Sidar; Ucku, Duygu; Cozzolino, Mario; Kanbay, Mehmet

doi:10.1007/s40620-022-01432-8

Cited by 4 publications

(5 citation statements)

References 110 publications

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“…Also, in the patients with psoriasis, hypoxia‐inducible factors (HIFs) were upregulated and promotes the development of psoriasis by inducing the expression of vascular endothelial growth factor (VEGF) 28 . Notably, HIFs also play a crucial role in pathogenesis of CKD through multiple mechanisms 29 . Additionally, patients with psoriasis also had high levels of interleukin‐17 30,31 .…”

Section: Discussionmentioning

confidence: 99%

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Psoriasis and risk of chronic kidney diseases: A population‐based cross‐sectional study and Mendelian randomization analysis

Yin

Zhou

et al. 2023

Nephrology

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BackgroundConflicting results have been reported regarding the association between psoriasis and risk of chronic kidney diseases (CKD). Furthermore, the causal nature of the possible association remains unexplored.MethodsWe conducted a population‐based cross‐sectional study using data from National Health and Nutrition Examination Survey (NHANES). Logistic regression analyses were conducted to estimate potential association between psoriasis and CKD risk. Further, we evaluated causality by performing a Mendelian randomization analysis using large‐scale genome‐wide association studies of psoriasis and CKD. Inverse variance‐weighted (IVW) analysis was used as the primary method.ResultsIn the observational study, 16 750 participants were included. Overall, 39 of 429 patients with psoriasis had CKD (9.1%) compared with 1481 of 16 321 without psoriasis (9.1%). In the fully adjusted model, psoriasis was not associated with CKD (OR: 0.77, 95%CI: 0.53–1.10). In the MR analysis, 36 single‐nucleotide polymorphisms (SNPs) were selected as instrumental variables. The IVW analysis reported that genetically predicted psoriasis was associated with a higher risk of CKD (OR: 1.025, 95%CI: 1.001–1.049). After removing 2 SNPs associated with heterogeneity, the association remained (OR: 1.028, 95%CI: 1.006–1.050).ConclusionGenetically predicted psoriasis was associated with a higher risk of CKD. This association may be important for clinicians to monitor kidney function and prescribe potentially nephrotoxic drugs during psoriasis management.

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Section: Discussionmentioning

confidence: 99%

“…28 Notably, HIFs also play a crucial role in pathogenesis of CKD through multiple mechanisms. 29 Additionally, patients with psoriasis also had high levels of interleukin-17. 30,31 This proinflammatory factor was also involved into renal inflammation and various renal diseases.…”

Section: Mr Methodsmentioning

confidence: 99%

Psoriasis and risk of chronic kidney diseases: A population‐based cross‐sectional study and Mendelian randomization analysis

Yin

Zhou

et al. 2023

Nephrology

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“…In a similar manner, a role for HIF-1α is also implicated in other calcific diseases in the vasculature 54,55 . Osteogenic transdifferentiation of vascular smooth muscle cells is promoted by raised levels of inorganic phosphate via the activation HIF-1α under normoxic conditions 56 .…”

Section: Calcificationunclassified

Role of hypoxia inducible factor HIF-1⍺ in heart valves

Georgy¹,

Salhiyyah

Yacoub³

et al. 2023

gcsp

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The 2016 Albert Lasker Basic Medical Research Award and subsequently the 2019 Nobel Prize in Physiology or Medicine were awarded to William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza for their work on how cells sense and adapt to hypoxic conditions. Their work showed that the changes in gene expression, cell metabolism, and tissue remodelling that occur in response to low oxygen concentrations are orchestrated by the transcription factor, hypoxia inducible factor-1a (HIF-1a). While the effects mediated by HIF-1a have been widely studied, its role in heart valves has only recently been investigated. These studies have shown that HIF-1a expression is evident in mechanisms that regulate the structure and function of heart valves. These include embryonic development, the regulation of the extracellular matrix, angiogenesis and the initiation of the calcification process. This review provides a background on the role and function of HIF-1a in response to hypoxia and a discussion of the available evidence of its involvement in the regulation of heart valves in health and disease.

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“…Characteristically, arterial stiffness is much more evident in the aorta as well as the other central arteries compared to those located in the periphery in this patient group [ 9 , 76 ]. An increased aortic stiffness can be considered to be a contributor to left ventricular hypertrophy and a fall in the perfusion of the coronary arteries as well as a marker of prognosis for mortality and cardiovascular morbidity with the pulse wave velocity of the aorta being an independent predictor for all-cause and cardiovascular mortality [ 9–12 , 77 , 78 ]. Furthermore, small vessel disease in the cerebral structures has also impacted the development of cognitive impairment in CKD patients [ 79 ].…”

Section: Introductionmentioning

confidence: 99%

Early aging and premature vascular aging in chronic kidney disease

Tanrıöver

Çöpür

Mutlu

et al. 2023

Clinical Kidney Journal

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Aging is the progressive decline of body functions and a number of chronic conditions can lead to premature aging characterized by frailty, a diseased vasculature, osteoporosis and muscle wasting. One of the major conditions associated with premature and accelerated aging is chronic kidney disease (CKD) which can also result in early vascular aging and the stiffening of the arteries. Premature vascular aging in CKD patients has been considered as a marker of prognosis of mortality and cardiovascular morbidity and therefore requires further attention. Oxidative stress, inflammation, advanced glycation end products, fructose and an aberrant gut microbiota can contribute to the development of early aging in CKD patients. There are several key molecular pathways and molecules which play a role in aging and vascular aging including nuclear factor erythroid 2-related factor 2 (Nrf-2), AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1) and klotho. Potential therapeutic strategies can target these pathways. Future studies are needed to better understand the importance of premature aging and early vascular aging and to develop therapeutic alternatives for these conditions.

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Hypoxia-inducible factor signaling in vascular calcification in chronic kidney disease patients

Cited by 4 publications

References 110 publications

Psoriasis and risk of chronic kidney diseases: A population‐based cross‐sectional study and Mendelian randomization analysis

Psoriasis and risk of chronic kidney diseases: A population‐based cross‐sectional study and Mendelian randomization analysis

Role of hypoxia inducible factor HIF-1⍺ in heart valves

Early aging and premature vascular aging in chronic kidney disease

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