Hypoxia-inducible factor (HIF): The link between obesity and COVID-19

AbdelMassih, Antoine; Yacoub, Elaria; Husseiny, Reem; Kamel, Aya; Hozaien, Rafeef; Shershaby, Meryam El; Rajab, Maram; Yacoub, Shenoda; Eid, Maryam; Elahmady, Maryam; Gadalla, Mamdouh A.; Mokhtar, Sherouk; Hassan, Alaa A.; Abou-Zeid, Aya S.; Hussein, Mohammed M.; Aboushadi, Nour; Emad, Nadine; Zahra, Nihal; Hassan, Aya; Hussein, Eman A.; Ibrahim, Nourhan; Nahhas, Nadine El; Elahmady, Tasneem; Khallaf, Mohamed; Mustafa, Hadeel; Anis, Nancy; Albehairy, Mirna; Hanna, Farid G.; Moris, Laila; Ye, Jianping

doi:10.1016/j.obmed.2020.100317

Cited by 36 publications

(33 citation statements)

References 39 publications

(32 reference statements)

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“…One of the main reasons for the development of SI and mortality in COVID-19 is hypoxemia linked with respiratory failure and systemic tissue hypoxia associated with several causes of impaired oxygen transport [ 63 , 64 , 65 , 66 ].…”

Section: Systemic Reactions In Covid-19mentioning

confidence: 99%

“…Similarly, hypoxemia/hypoxia is thought to be an independent risk factor for hospital mortality in the most critical forms of ARDS [ 63 , 64 , 65 , 66 ], as it is linked to the development of multiple organ failure and coagulopathy [ 63 , 64 , 65 , 66 ]. COVID-19 patients frequently develop hypoxemia without signs of breathlessness though their chest X-rays show diffuse pneumonia, and dangerous levels of blood oxygen are detected [ 63 ].…”

Section: Systemic Reactions In Covid-19mentioning

confidence: 99%

“…Hypoxia as a damaging factor simultaneously stimulates numerous cellular stress signaling pathways, primarily those involving Hypoxia-Inducible Factors (HIF) [ 67 ], NF-KappaB, and mitogen-activated protein kinases (MAPK) [ 68 , 69 , 70 ]. In turn, viral infection and obesity are independent factors that raise HIF-1 expression, exacerbating the production of pro-inflammatory cytokines and raising the risk of cytokine storm [ 65 ]. As a result, increasing hypoxia amplifies the COVID-19 disease process, contributing to the establishment of vicious pathogenetic circles alongside hyperinflammation and coagulopathy.…”

Section: Systemic Reactions In Covid-19mentioning

confidence: 99%

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Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes)

Гусев

Sarapultsev

et al. 2021

IJMS

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The COVID-19 pandemic examines not only the state of actual health care but also the state of fundamental medicine in various countries. Pro-inflammatory processes extend far beyond the classical concepts of inflammation. They manifest themselves in a variety of ways, beginning with extreme physiology, then allostasis at low-grade inflammation, and finally the shockogenic phenomenon of “inflammatory systemic microcirculation”. The pathogenetic core of critical situations, including COVID-19, is this phenomenon. Microcirculatory abnormalities, on the other hand, lie at the heart of a specific type of general pathological process known as systemic inflammation (SI). Systemic inflammatory response, cytokine release, cytokine storm, and thrombo-inflammatory syndrome are all terms that refer to different aspects of SI. As a result, the metabolic syndrome model does not adequately reflect the pathophysiology of persistent low-grade systemic inflammation (ChSLGI). Diseases associated with ChSLGI, on the other hand, are risk factors for a severe COVID-19 course. The review examines the role of hypoxia, metabolic dysfunction, scavenger receptors, and pattern-recognition receptors, as well as the processes of the hemophagocytic syndrome, in the systemic alteration and development of SI in COVID-19.

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Section: Systemic Reactions In Covid-19mentioning

confidence: 99%

Section: Systemic Reactions In Covid-19mentioning

confidence: 99%

Section: Systemic Reactions In Covid-19mentioning

confidence: 99%

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Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes)

Гусев

Sarapultsev

et al. 2021

IJMS

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“…Resveratrol (RSV), a plant-derived polyphenol acting as a vital antioxidant, can protect various organs from oxidative stress at least partially via the PI3K/Akt-mediated NRF2 signaling pathway (104). The potential role of RSV in preventing and treating COVID-19 has been suggested by various studies (105). Studies revealed that RSV pretreatment directly increases cell viability and expression of SOD, CAT, and GPX, while decreases intracellular ROS levels and cell apoptosis.…”

Section: Regulation Of Nrf2 Via Pi3k/akt Signaling Pathwaymentioning

confidence: 99%

“…Inhibitors to HIF-1a and HIF-1-associated signaling pathways are promising in reversing both diseases. RSV inhibits hypoxiamediated overexpression of HIF-1a, thus might have a protective effect on COVID-19 (105). Inhibitors to the Akt/mTOR/HIF-1 signaling are also promising in treating COVID-19.…”

Section: Through Plant Metabolites and Their Synthetic Derivatives Targeting Hif-1-related Pathwaysmentioning

confidence: 99%

Comparison of COVID-19 and Lung Cancer via Reactive Oxygen Species Signaling

2021

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COVID-19 and lung cancer are two severe pulmonary diseases that cause millions of deaths globally each year. Understanding the dysregulated signaling pathways between them can benefit treating the related patients. Recent studies suggest the critical role of reactive oxygen species (ROS) in both diseases, indicating an interplay between them. Here we reviewed references showing that ROS and ROS-associated signaling pathways, specifically via NRF2, HIF-1, and Nf-κB pathways, may bridge mutual impact between COVID-19 and lung cancer. As expected, typical ROS-associated inflammation pathways (HIF-1 and Nf-κB) are activated in both diseases. The activation of both pathways in immune cells leads to an overloading immune response and exacerbates inflammation in COVID-19. In lung cancer, HIF-1 activation facilitates immune escape, while Nf-κB activation in T cells suppresses tumor growth. However, the altered NRF2 pathway show opposite trends between them, NRF2 pathways exert immunosuppressive effects in both diseases, as it represses the immune response in COVID-19 patients while facilitates the immune escape of tumor cells. Furthermore, we summarized the therapeutic targets (e.g., phytochemicals) on these ROS pathways. In sum, our review focus on the understanding of ROS Signaling in COVID-19 and lung cancer, showing that modulating ROS signaling pathways may alleviate the potentially mutual impacts between COVID-19 and lung cancer patients.

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Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives

Sun

Scherer

2023

Comprehensive Physiology

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Hypoxia-inducible factor (HIF): The link between obesity and COVID-19

Cited by 36 publications

References 39 publications

Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes)

Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes)

Comparison of COVID-19 and Lung Cancer via Reactive Oxygen Species Signaling

Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives

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